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Careers at NCATS

We are looking for innovative partners to join our dynamic team. Learn more about current job opportunities at NCATS.

Job Opportunities

Information provided by candidates will remain confidential and will not be released outside NCATS' search process without signed consent from candidates.

Postdoctoral Positions in the Division of Preclinical Innovation

NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. The U.S. Department of Health and Human Services and NIH are Equal Opportunity Employers.

NIH is dedicated to building a diverse community in its training and employment programs.

Federal Background Check

Selected candidates for any fellowship opportunity described above are subject to a federal background check, using Standard Form-85 (read SF-85). Section 14 of the form asks, "In the last year, have you used, possessed, supplied, or manufactured illegal drugs?" The question refers to the illegal use of drugs or controlled substances in accordance with federal laws, even though allowed under state laws. Acceptance into all fellowship programs is conditional upon a successful background check.

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Deputy Director, Division of Clinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Clinical Innovation
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks applications from outstanding candidates to be deputy director of the center’s Division of Clinical Innovation (DCI). DCI manages the Clinical and Translational Science Awards (CTSAs) Program. The CTSA Program supports a national network of medical institutions that helps turn research discoveries into improved health care more quickly. The Program provides resources for local and national research communities to improve the quality and efficiency of all phases of translational research. It also supports investigators’ career development.

Core Responsibilities

The DCI deputy director will:

  1. Oversee the activities of the Office for Planning, Evaluation, Analysis and Reporting (OPEAR). OPEAR coordinates submitted grant applications, budgets and communications for DCI.
  2. Support the DCI director in guiding the CTSA Program.
  3. Establish a vision of innovation and national leadership, with a broad charge to improve the implementation of all aspects of human subject studies.
  4. Create, test and implement improvements to the CTSA Program and related NCATS activities.
  5. Help the DCI director provide leadership and stewardship of NCATS’ investments that bring innovation to clinical research.
  6. Advise NCATS senior leadership, including the director, on strategic program goals and activities. Recommend operational and administrative processes to improve overall efficiency.
  7. Bring broad scientific knowledge and vision to set priorities for DCI. Clearly convey that vision to NIH and NCATS leadership.

Qualifications

The ideal candidate should have a doctoral degree (Ph.D. or equivalent). Senior-level research experience or knowledge of research programs is also needed. This experience should include moving research from the laboratory to preclinical development and clinical trials and showing public health benefit.

The selected candidate will:

  • Have excellent verbal and written communication skills.
  • Be a recognized and respected leader in the field.
  • Have a visionary, forward-thinking mindset.
  • Demonstrate strategic thinking.
  • Work collaboratively.
  • Consult with others to solve problems and make decisions.

The application should detail employment and research experience.

Salary/Benefits

The salary will be based on qualifications, experience and accomplishments. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Please submit a cover letter describing your interest in the position to NCATSSeniorRecruit@mail.nih.gov. Attach a current curriculum vitae with a complete bibliography and provide contact information for three references. Please submit questions about this position to Josh Fessel, M.D., Ph.D., at josh.fessel@nih.gov.

This position will be filled under a Title 42(f) appointment. Application packages will only be accepted electronically and must be received by 11.59 p.m. EDT on July 31, 2024.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, and submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

NIH inspires public confidence in our science by maintaining high ethical principles. Our employees are subject to federal government-wide regulations and statutes and to the specific regulations described on the NIH Ethics Program website.

All information provided by candidates will remain confidential and will not be released outside the NCATS search process without a signed release from candidates. NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities. The U.S. Department of Health and Human Services and NIH are Equal Opportunity Employers.

Formulation Scientist (Staff Scientist), Therapeutic Development Branch, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Therapeutic Development Branch
Division of Preclinical Innovation
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from outstanding candidates to fill a formulation scientist (staff scientist) position. The position is in the Therapeutic Development Branch (TDB) in the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. The selected applicant will manage and operate formulation development in dosage form development and drug manufacturing. The research will be conducted within the TDB formulation group.

The scientists in DPI come from a broad range of fields, including drug discovery, medicinal chemistry, pharmacology and preclinical development. Their research plays a leading role in NCATS’ goals to develop new ways to reduce, remove or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce. Applicants must have a strong grasp of principles and practices of pharmaceutics and formulation development and manufacturing as they relate to developing sterile and nonsterile dosage forms of drugs. The formulation scientist will serve as an internationally recognized expert. They also will be the program’s contact with other government agencies and the scientific community. They will form good working relationships with other experts in the field and contract manufacturing organizations (CMOs) to meet program goals.

Core Responsibilities

The selected candidate will:

  1. Plan formulation-development strategies by Design of Experiments based on chemical and physical characteristics of the drug candidate to the targeted dosage forms, mainly as oral capsules, injectables or inhalers.
  2. Run equipment for creating the dosage form and conducting relevant quality control testing. Schedule studies. Inform laboratories of priorities for scheduled work. Solve problems that arise during experiments. Ensure timely reporting of results by closely tracking major events during individual experiments.
  3. Manage formulation-related functions of the program that further drug development.
  4. RepresentNIH in talks with the U.S. Food and Drug Administration (FDA) and CMOs about whether formulation development data and other pharmaceutical information provided in an Investigational New Drug (IND) application is sufficient.
  5. Advise on available resources for formulation development and dosage form manufacturing and on specific agents under development.
  6. Determine budgetary needs for formulation development and manufacturing efforts and prepare budget forecasts.
  7. Assess scientific significance of findings and suggest more experiments if important questions remain.
  8. Respond to scientific and technical questions from clinicians, toxicologists, pharmacologists, chemists, pharmacists, pharmaceutical scientists and administrative personnel. Questions will relate to chemical and pharmaceutical traits of newly created agents at both the preclinical and clinical stages of development.
  9. Conduct literature searches and critique project applications on their feasibility and scientific merit and how practical their pharmaceutical approaches are.
  10. Write laboratory protocols and/or statements of work for CMOs for new projects that involve the development and/or manufacture of drug products.
  11. Serve as the contracting officer’s representative for contracts with research organizations.
  12. Serve as scientific support for reviewing proposals against criteria that the incumbent has helped identify as part of the scientific team.
  13. Advise national and international scientists on research results to help them improve programs and speed the development of new therapeutic agents.
  14. Promote the drug development program through lectures, visits and articles.

Qualifications

Applicants should have a doctoral degree (Ph.D. or equivalent) in pharmaceutical or formulation science, biomedical engineering or pharmaceutical chemistry with related professional experience. The ideal applicant should be self-motivated, have a strong work ethic and a keen attention to detail, and be able to work on multiple projects at once. The applicant should have strong oral and written communication skills, with a proven publication record in peer-reviewed journals.

Preferred knowledge and experience includes:

  • Strong background in wet lab operation for formulation development of drug product dosage forms, manufacturing and quality control.
  • Thorough knowledge of pharmaceutical literature related to the program’s mission. Trained in the following instruments: HPLC/UPLC, DSC, TGA, FTIR, SEM, nano- homogenizer, spray-dryer, dissolution apparatus and lyophilizer.
  • Ability to provide guidance to researchers on methods, approaches, concepts, probable results and significance of studies.
  • Experience and familiarity with the FDA’s Current Good Manufacturing Practice regulations, especially those involving formulation development and pharmaceutical manufacturing.
  • Ability to discuss and advise investigators on the pharmaceutical aspects of therapeutic agents.

Salary/Benefits

The salary will be based on qualifications, experience and accomplishments. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Please submit a cover letter describing your interest in the position, including a career synopsis (one to three pages), a current curriculum vitae and complete bibliography, and provide contact information for three references to Haksong Jin, Pharm.D., M.S., via ncatsssrecruit@mail.nih.gov. The position will remain open for 30 days beginning June 10, 2024.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Data Scientist, Office of Program Evaluation, Analysis and Reporting, Division of Clinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Office of Program Evaluation, Analysis, and Reporting
Division of Clinical Innovation
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from outstanding candidates for a data scientist position. The position is in the Office of Program Evaluation, Analysis and Reporting (OPEAR) in NCATS’ Division of Clinical Innovation (DCI). Established in 2023, OPEAR applies scientific expertise and methods to expand the evidence base for demonstrating the impact of the Clinical and Translational Science Awards (CTSA) Program and evaluate program performance to enhance stewardship of the program.

OPEAR: 

  • Plans, conducts and supports evaluation, analysis and reporting for DCI.
  • Coordinates, provides and supports strategic communications for DCI.
  • Works with offices within NCATS and across NIH, as well as external partners and stakeholders, to accomplish related goals.

Core Responsibilities

As a member of this newly established office, the successful candidate will join OPEAR at an exciting time, helping to advance evaluation, analytics and reporting for the CTSA Program, NIH’s largest grant program.

The successful candidate will apply advanced data science methods to large, complex administrative and research data sets and databases to evaluate the CTSA Program research projects and workforce. Specific work will involve:

  1. Extracting diverse data types from relational databases and cleaning, classifying and transforming these data to create data sets for analyses. Data type examples include structured and unstructured information.
  2. Applying deterministic and probabilistic linking of diverse data sets to expand evaluation questions that can be addressed.
  3. Conducting advanced statistical modeling, including machine learning (ML) and artificial intelligence (AI) methods, to glean insights from data on the performance and impact of CTSA research and workforce investments.
  4. Developing static and interactive data visualizations to support data exploration, portfolio analysis, and policy and management decisions. This includes creating interactive query tools and dashboards.
  5. Interpreting and communicating the results with diverse audiences in different forms, such as reports, blogs and websites, conference presentations, and peer-reviewed journal articles.

A wide range of historical past and current data (including CTSA Program data) on NIH research projects and personnel are available in NIH’s relational database, IMPAC II. IMPAC II data can be linked to other administrative, research and survey data including publications, citations, patents and licenses, public health and clinical guidelines and policies, and economic indicators. The candidate will apply data science expertise and analytics tools to these data to address key evaluation questions. Examples of evaluation questions include:

  • How are scientific discoveries (e.g., publications and patents) being disseminated and used to improve health and bring economic benefits (e.g., new health policies or clinical guidelines, product licenses for new drugs or medical devices, new start-ups based on intellectual property)?
  • How have CTSA Program-supported trainees’ careers progressed with respect to getting future research appointments and NIH research funding?
  • What is the distribution of topics covered in publications generated from CTSA Program-supported work?
  • What is the degree of collaboration between CTSA Program grantee institutions, and collaborator and partner institutions?

The successful candidate will apply a wide range of software tools and platforms for different tasks, including:

  1. Data extraction (e.g., SQL).
  2. Data linkage (e.g., deterministic or probabilistic matching algorithms).
  3. Statistical analyses (e.g., R, SAS, Stata).
  4. Topic modeling (e.g., Latent Dirichlet Allocation).
  5. Classification (e.g., random forest).
  6. Static and interactive data visualizations (e.g., Shiny-RStudio, Tableau, Power BI).
  7. Geospatial analyses (e.g., ArcGIS).

The candidate will follow best practices in producing, storing, and protecting the privacy of data. They also will produce excellent documentation on characterizing data, data sets and reports and on writing code.

The successful candidate will work with a wide range of internal and external customers and partners. Together, they will define the evaluation questions, assess the availability of data, conduct the analyses, and communicate the results to diverse audiences. Key stakeholders include:

  • DCI and NCATS executive leadership.
  • CTSA Program grantee principal investigators, evaluators and communicators.
  • Other NIH offices.
  • Other federal partners.
  • Professional societies.
  • The public.

The candidate will apply outstanding communication, interpersonal and teamwork skills in delivering products that support the CTSA Program.

Qualifications

The successful candidate must have a bachelor’s degree or higher in mathematics, statistics, computer science, data science or some other highly quantitative field (e.g., physics, economics, engineering) directly related to the position. This can be replaced by an equivalent mix of education and experience. The candidate also must have one year of specialized experience equivalent to the GS-12 level in the federal service.

Specialized experience includes:

  • Identifying appropriate research methods and applying critical thinking and creativity to all projects and tasks.
  • Designing and using data science and analytical methods for tasks across the whole data life cycle. This includes ingesting, storing, cleaning, linking, classifying, transforming, analyzing, modeling, visualizing, reporting, communicating and disseminating data.
  • Preparing data sets. This includes assessing and addressing data quality, data outliers, errors, or missing data; creating data documentation and metadata; using feature engineering, exploratory data analysis and predictive models; and designing and creating data visualizations.
  • Using iterative processes to carry out data science projects (e.g., working closely with customers to identify business problems and data available to solve them); preparing data sets and doing feature engineering; and building models to solve identified problems.
  • Analyzing a broad range of data types (e.g., structured data, unstructured text, images) and data sets (e.g., relational databases; research, survey and administrative data sets; cloud-based data). Experience analyzing grants management data and bibliometrics data is desirable but not required.
  • Assessing multiple data science models or algorithms and choosing the best using a performance metric, such as Area Under the Curve.
  • Being skilled in multiple programming languages, such as, R, Python, SQL and MATLAB. Having experience using an integrated development environment, such as RStudio.
  • Applying knowledge of statistical theory to design and execute statistical models. Analytical methods include, but are not limited to, general linear, logistic and log-linear regression, longitudinal analyses, survival analysis, social network analysis, geospatial analysis and mapping, cluster analysis, trend analysis and time-series analysis.
  • Applying knowledge of AI and ML methods to analyze data such as clustering, classification, random forest, dimensionality reduction, neural networks, supervised and unsupervised machine learning, and natural language processing methods.
  • Being skilled in designing and creating static and interactive data visualizations, including dashboards. Being experienced in data visualization methods and tools, data analysis tools, and data reporting platforms and tools, such as Power BI, Tableau, Shiny-RStudio, ArcGIS and QGIS. Using such data analysis and visualization tools to tell stories with data and analysis.
  • Communicating effectively, in both speech and writing, about findings, conclusions and recommendations. Methods can include presentations, reports, scientific journal articles, blogs and other venues. Audiences for this position include, but are not limited to, NCATS and NIH leadership, CTSA researchers and the broader scientific community, policy makers, Congress, and the public.
  • Having excellent interpersonal and collaboration skills to interact with a wide range of internal and external customers and audiences. Examples include executive leadership, senior scientists and the public.

Salary/Benefits

The salary range is based on experience and accomplishments for a Data Scientist (1560 job series) at the GS-13 level. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Submit the following information to Robin M. Wagner, Ph.D., M.S., director, Office of Program Evaluation, Analysis and Reporting, at robin.wagner@nih.gov: (1) a cover letter describing your interest in the position; (2) a current curriculum vitae that includes a complete bibliography and list of competencies in specific software tools and platforms; and (3) contact information for at least three references.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Staff Scientist, Division of Preclinical Innovation, Chemical Genomics Branch, Stem Cell Translation Laboratory

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a staff scientist position in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL addresses the top methodological or technical problems that hinder the use of human pluripotent stem cells (hPSCs) in drug development. The SCTL also works to quickly deliver the resulting protocols, standards, data and tools to the public.

Core Responsibilities

The successful candidate will play a key role in leading SCTL projects, using their expertise in neurodevelopmental biology to develop and improve hPSC differentiation practices for making cells of neural lineages. These cells are necessary for disease modeling, drug discovery and therapeutic advancement. The selected candidate will develop research initiatives that align with NCATS’ and SCTL’s strategic plans. They should be very creative and work well with teams of people from different disciplines. The candidate will mentor trainees and interact closely with a range of partners. They will also draft manuscripts, publish results in peer-reviewed journals, and present findings at scientific meetings.

Qualifications

The ideal candidate should have a doctoral degree (Ph.D. or equivalent) in developmental neurobiology and 4 or more years of postdoctoral training in the stem cell and neurodevelopmental biology fields. The candidate must have experience in these areas:

  1. Working with human induced pluripotent stem cells, or iPSCs, embryonic stem cells, and/or adult stem cells.
  2. Investigating stem cell biology.
  3. Differentiating stem cells to develop different neural cell types.
  4. Testing small molecules or other modalities and using them to develop therapeutics.

The candidate should have experience as a developmental neurobiologist. In particular, they should have worked with hPSCs and applied their neurodevelopmental background to develop neural differentiation protocols. Candidates should have a strong interest in neurodevelopmental biology and its role in hPSC technologies. This interest should be proven by their publication record.

The selected candidate will: 

  • Have excellent verbal and written communication skills.
  • Be able to interpret, summarize and present scientific results clearly and accurately.
  • Stay current with advances in neurodevelopmental and stem cell biology.
  • Explore and master novel technologies and create and develop new methods.

Salary/Benefits

The salary will be based on qualifications, experience and accomplishments. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Please submit a cover letter describing your interest in the position to NCATSstemcellhiring@mail.nih.gov. Attach a current curriculum vitae with a complete bibliography and provide contact information for three references.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, and submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Program Officer/Program Director, Clinical Research Resources Section, CTSA Clinical Affairs Branch, Division of Clinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Clinical Innovation
CTSA Clinical Affairs Branch, Clinical Research Resources Section
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks outstanding candidates to be a nonsupervisory program officer/program director (PO/PD). This position will be in the Clinical Research Resources Section (CRRS) of the Clinical and Translational Science Awards (CTSA) Program Clinical Affairs Branch (CAB) in the center’s Division of Clinical Innovation (DCI).

The CRRS:

  1. Develops and shares resources for planning, implementing and conducting NIH-supported clinical research and trials
  2. Provides resources to create products and tools to improve participant recruitment and the type of information collected and used in clinical studies by using standardized and agreed-upon metrics by stakeholders and key informants
  3. Promotes clinical research quality standards
  4. Ensures the protection of human subjects research within CTSA Program projects
  5. Develops, implements and monitors human subjects research protection policy across NIH and with other government agencies, industry, academia and patient-support groups
  6. Supports the Trial Innovation Network (TIN)
  7. Strives to enhance recruitment through the TIN via a Collaborative and Innovative Acceleration Award (see NOT-TR-23-026)

Core Responsibilities

The CRRS PO/PD will support programs and initiatives both within the section and across the CAB. They also will assist the CRRS chief in developing, testing, and disseminating recruitment strategies while assessing their effectiveness.

Qualifications

Each applicant should have proven management skills and broad knowledge and experience in a relevant scientific field. Candidates also should have proven real-world experience in:

  1. Creating and providing resources to plan, share and assess program products
  2. Assessing resources to improve participant recruitment in clinical studies
  3. Monitoring and improving recruitment strategies
  4. Applying best practices related to recruitment, recruitment resources and solving recruitment barriers

The successful candidate should have expertise using data science to improve participant recruitment, safety and retention in clinical trials. They should have proven experience in planning, creating and testing tools to support clinical trials in novel groups and settings. They also should have a strong history of working with diverse federal and nonfederal organizations. Candidates should have expertise working on teams that cross multiple fields and communicating with others to advance scientific program goals.

Salary/Benefits

The salary range is based on experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) (602 series) or Social Behavioral Scientist (101 series) at the GS-14 level. A full civil service benefits package — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit a cover letter that describes your interest in the position. Include a current curriculum vitae with a complete bibliography and provide contact information for at least three references. Send the materials to Ken L. Wiley, Jr., Ph.D., section chief, CRRS, CAB, DCI, at ken.wiley@nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Staff Scientist (Data Scientist), Division of Preclinical Innovation, Chemistry Technologies Development Laboratory

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemistry Technologies Development Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a staff scientist (data scientist) position in the Chemistry Technologies Development (CTD) laboratory (administered by the Chemistry Technology program) within the center’s Division of Preclinical Innovation (DPI). The mission of the CTD laboratory is to conduct chemistry and biological research on various diseases and find opportunities at the interfaces of chemistry, biology and medicine. The CTD employs state-of-the-art methods in disease model development and characterization, high-throughput chemogenomics screening, medicinal chemistry/chemical biology, and therapeutic development to pursue a wide range of research goals in collaboration with other NIH intramural scientists, academic colleagues and industry partners.

The CTD laboratory pursues five core domains of research: (1) biologically active small molecule discovery, (2) disease model design/characterization, (3) mechanistically focused drug positioning, (4) innovations in bioinformatics, and (5) advancing concepts in precision medicine. The longer-term vision includes two independent precision medicine teams focused on several cancer subtypes in collaboration with the National Cancer Institute.

Core Responsibilities

The successful candidate will develop novel informatics and statistical methods/workflows and proof-of-concept tools to support the integration, analysis and interpretation of translational research data and make these outcomes publicly available to the broader research community. These data result from efforts in basic research, patient-oriented research and population-based research. The selected candidate will interact closely with the CTD laboratory director, computational and noncomputational (e.g., biologists, chemists, clinicians) CTD and NCATS scientists, and our academic collaborators. He or she will contribute to the strategic vision and to the mentoring of trainees. The selected candidate will be encouraged to seek out collaborations within NCATS and NIH or externally to further amplify and improve the center’s CTD informatics methods and software. He or she will elaborate on machine and deep learning and architectures from the aggregation and cleaning of in-house translational research data (e.g., high-throughput screens, multi-omic knowledge sources on chemical, biological or disease annotations). To augment translational research efforts, the selected candidate will promote the use of and/or contribute to the development of chemical, biological and disease standards that help connect complementary lines of information.

The selected candidate will be expected to create and maintain documentation for methods/workflows to enable their reuse by CTD members or other researchers. Furthermore, he or she will contribute to the establishment of software development and deployment best practices for CTD, including acting as an owner/point of contact for repositories, data systems and servers. The selected candidate will contribute to building a consolidated scientific computing environment through the integration and interoperability of libraries and software and will apply or develop appropriate, state-of-the art methods to support large-scale data-acquisition efforts within the DPI. Active participation in CTD and NCATS committees and meetings, as appropriate, will be encouraged to showcase and obtain feedback (e.g., user feedback) on methods and software developed. The selected candidate will be expected to draft manuscripts and publish results in high-impact, peer-reviewed scientific journals and to present results at internal and external scientific meetings.

Qualifications

The ideal candidate should possess a doctoral degree (M.D., Ph.D. or equivalent) in a relevant field and be a recognized expert in the field. Applicants should possess a broad range of informatics experience that includes at least some of the following: machine learning and/or deep learning (Bayesian inference, probabilistic programming, NLP, TensorFlow, etc.); experience in graph, NoSQL and/or RDBMS databases and semantic data standards (e.g., OWL, RDF); scripting programming for high-throughput data processing and visualization (e.g., R, Python); Linux environments, high-computing servers and cloud computing; versioning systems (GitHub); and full-stack software development. A strong preference will be given to applicants with knowledge of biology and/or chemistry and an understanding of data provenance (e.g., cell biology, methods for measuring multi-omic data, high-throughput screens, biochemistry, genetics). Candidates should have proven experience in analyzing a broad range of data types across different diseases and exploiting these data for therapeutic development.

The selected candidate should have excellent interpersonal and verbal and written communication skills, and he or she should possess excellent analytical, organizational and time-management skills. The desire and drive to seek out and master novel technologies and to develop new ones is expected.

Salary/Benefits

The salary will be based on qualifications, experience and accomplishments. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Please submit a cover letter describing your career goals and interest in the position, including a research summary (one to two pages); a current curriculum vitae with a complete bibliography; and provide contact information for at least three references to NCATSSSRecruit@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Program Officer (Program Director), Trial Innovation Network Section, CTSA Clinical Affairs Branch, Division of Clinical Innovation

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Clinical Innovation                           
CTSA Clinical Affairs Branch, Trial Innovation Network Section                           
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates for a program officer (program director) position in the Clinical Affairs Branch, Trial Innovation Network (TIN) Section within the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership abilities and demonstrated expertise in improving clinical trial efficiency through tool development, regulatory science in clinical trials, health disparities/equity trials, community engagement, and clinical trial training and education. The selected candidate also will be expected to broaden the scope of clinical trial questions and the clinical trial enterprise so that trials address the health concerns of people in a broad variety of situations and locations, including those living in rural and remote locations, individuals of diverse cultures and beliefs, and minority populations.

The TIN develops trial efficiency tools to test, disseminate and incorporate the tools developed by this section and other parts of the NCATS TIN, ensuring the dissemination and sustainability of these tools within NCATS-funded programs, the Clinical and Translational Science Awards (CTSA) Program, NIH and the extramural research community. To facilitate this, the TIN program officer (program director) will work with clinical trial networks and training programs through NIH and non-NIH programs to ensure the tools are accessible and used appropriately. This process will be iterative and bilateral, so suggestions and requests from collaborators will be provided back to the TIN to ensure the needs of participants, families, communities, providers and researchers are optimized. To this end, community engagement will be essential to enhance the tool development process, increase uptake and dissemination and ensure that the necessary tools are developed. The TIN also supports the Helping to End Addiction Long-term® Initiative or NIH HEAL Initiative®.

Core Responsibilities

The program officer (program director) will be responsible for project and network activities and coordinating a toolkit for investigators to use TIN tools. The section’s products and resources aim to improve clinical trial efficiency, maximize safety and enhance the types of information within clinical trials. Examples of the activities within the section will include implementing techniques and tools to enhance trial design, site selection efficiency, Institutional Review Board efficiency, startup, and expansion efficiency, for both NIH and investigator expectations, personnel and site turnover issues. The program officer (program director) will manage cooperative agreements and programs within the TIN and develop trial-related initiatives to improve the efficiency of the clinical trial enterprise and work with TIN investigators on trial-related workgroups.

Qualifications

Each applicant should possess a bachelor’s or graduate/higher-level degree in either the behavioral or social sciences, or related disciplines appropriate to this position or a bachelor’s or graduate/higher-level degree with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position and have extensive knowledge and experience in clinical research and knowledge of regulatory science related to clinical trials. Candidates should have (1) recognizable accomplishments and career progression in a research activity related to health or biomedical/behavioral sciences, as well as competence in program management with extensive experience as a program director; (2) the ability to communicate effectively to plan, initiate, administer and evaluate a scientific program successfully; (3) knowledge in the dynamics of health-related research including regulatory science; (4) the ability to understand the internal relationships of partner and grantee organizations conducting research, as well as the practices and policies affecting national health research efforts; (5) the ability to work effectively and cooperatively with others; (6) experience developing and maintaining good working relationships with review groups, members of national advisory councils and boards, representatives of academic institutions, the scientific community, public and private organizations and agencies, and the general public, as well as supervisors, colleagues and subordinates.                           

The selected candidate should appreciate the challenges of working with diverse stakeholders and communicating impact clearly to various audiences. The selected candidate should be aware of new and emerging trends in clinical and translational science research and be able to communicate and collaborate well with others.

Salary/Benefits

The salary range is based on experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) — 602 series — or Social Behavioral Scientist (101 series) at the GS-14 level. A full civil service benefits package — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit a cover letter that describes your interest in the position. Include a current curriculum vitae with a complete bibliography and provide contact information for at least three references. Send the materials to Salina P. Waddy, M.D, FAHA, associate director, CAB, DCI, at salina.waddy@nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.                           

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Research Associate (Biology), Division of Preclinical Innovation, Chemical Technologies Group

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Chemical Technologies Group                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research associate (biology) position in the Chemical Technology group within its Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal and process chemists, and computational scientists who work on a broad portfolio of preclinical drug discovery projects, as well as programs that involve the development of innovative new technologies to enable the acceleration of biomedical research. The Chemical Technology group operates at the interface between chemistry and biology. A major focus of the team involves conducting large-scale chemogenomic screenings to identify novel targets and to develop novel strategies for therapeutic intervention, mostly focusing on oncologic indications. A second major focus of the team involves the discovery, optimization and advancement of novel biologically active small molecules.

Core Responsibilities

The selected candidate will maintain mammalian cell-line cultures and expand them to scale in preparation of high-throughput drug screening; prepare various media, stock supplies and other reagents for use in the laboratory; perform in vitro cell-based assays to support the molecular characterization of drugs’ mechanism of action. These include DNA/RNA extraction, PCR and western-blot. The selected applicant also will maintain accurate daily records of experiments and results and interpret, evaluate and discuss the result of each experiment as part of the experimental-planning process. The selected candidate will perform computer analysis of data and use various software to prepare data figures for both internal discussion and publication.

Qualifications

Applicants to this research associate (biology) position should possess a bachelor's degree in biology, biochemistry or other related life science discipline. A master’s in cell biology, immunology, biochemistry or other related life science discipline is preferred. The selected candidate should possess a conceptual understanding of cancer biology and knowledge of major oncogenic signaling pathways in human cancers, a strong background in cell biology, have at least two years of previous experience with standard molecular biology techniques (e.g., tissue culture, RNA and DNA extraction, PCR and western-blot) and be proficient at the bench. He or she should demonstrate attention to detail and possess strong organizational and interpersonal skills. Applicants also should possess excellent verbal and written communication skills, the ability to interpret, summarize and present scientific results in a clear, concise and accurate manner; and be able to work productively as a member of a diverse and dynamic multidisciplinary team.

The ideal candidate will have previous experience with high-throughput drug screening, Illumina next-generation sequencing platforms and related library preparation procedures (especially RNA-Seq and single-cell analysis), as well as documented knowledge of the hippo signaling pathway. Previous experience in microscopy, immunocytochemistry and flow cytometry, as well as strong computer literacy and Microsoft Excel proficiency — particularly with respect to graph/plots generation and analysis of large data sets — will be considered a plus.

Salary/Benefits

The salary will be based on qualifications, experience and accomplishments. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references to ncatspt3hiring@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Research Scientist (Virology) Position, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research scientist (virology) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge technologies — including tissue biofabrication, tissue chips, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies (e.g., scRNAseq) — to develop advanced 3-D cellular models to study viral infections and drug screening. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. The selected candidate also will be expected to work independently as a well-trained problem solver in virology. Effective communication and presentation skills are required. The selected applicant will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The selected candidate will draft technical reports, manuscripts and patent applications, and present work to internal and external collaborators as needed. The selected candidate also must be eligible to work in the U.S. with whomever NCATS collaborates worldwide.

Qualifications

Applicants to this research scientist position should possess a Ph.D. in virology, cell or molecular biology or pharmacology, and at least three years of postdoctoral experience. The selected candidate should have expertise in virology to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and drug testing. Applicants should have additional expertise in histology, fluorescence microscopy, flow cytometry, single-cell RNA sequencing (scRNAseq), and production of induced pluripotent stem cell-derived cells. Candidates with previous experience working in a BSL3 lab and in areas such as organoids, tissue chip, cell imaging, histology and engineering of cells with biosensors will be considered favorably.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Bioinformatician, Division of Preclinical Innovation, Chemical Genomics Branch, Stem Cell Translation Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Chemical Genomics Branch                           
Stem Cell Translation Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a bioinformatician position in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as induced pluripotent stem cells, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems.

The successful candidate will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS and collaborators at top academic institutions.

Core Responsibilities

Computational analysis is integral to the laboratory’s efforts in the deep characterization of stem cell states and functional cell types from different developmental lineages. The bioinformatician will be required to promptly turn around analysis results to respond to biologists’ ongoing projects, work on multiple projects in parallel, and coordinate and oversee data analysis with external service providers.

Qualifications

Applicants should have a master’s degree or higher in bioinformatics, computational biology or biomedical data science. The ideal candidate should have strong science communication skills; clear and effective data visualization skills; the ability to work well independently and in a team environment; creative problem-solving skills; and a proven ability to apply the cutting-edge, rigorous standards of the bioinformatics fields. Applicants should possess a solid knowledge of R statistical programming language; familiarity with the handling, management and storage of large-scale sequencing data; and experience querying public databases, including the SRA, GEO and dbGaP.

Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms (e.g., bulk and single-cell RNA-Seq; ChIP-seq methods, such as MeDIP-seq; bulk and single-cell ATAC-seq; and miRNA-seq). Experience with other ‑omics — such as WES, WGS and targeted sequencing methods — are a plus. The ideal candidate will have experience with preprocessing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, HTSeq, featureCounts, salmon, GATK) and R packages designed for the above-mentioned methods (e.g., DESeq2, limma, Seurat). A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of NIH’s high-performance computing capabilities, are preferred.

Salary/Benefits

The salary will be based on qualifications, experience and accomplishments. A full civil service benefits package is available. It includes retirement; health, life and long-term care insurance; and participation in a Thrift Savings Plan (401[k] equivalent).

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references to NCATSstemcellhiring@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Positions in the Division of Preclinical Innovation

The Division of Preclinical Innovation (DPI) is the intramural (i.e., on-site) research program of NCATS and is located in Rockville, Maryland, a few miles from the main NIH campus in Bethesda, Maryland. DPI focuses on early stages of the translational process, from target validation to first-in-human studies. More than 200 scientists from a variety of disciplines and across the spectrum from early-career scientists to senior leaders are responsible for advancing the diverse research portfolio of DPI. In addition to conducting cutting-edge laboratory research, DPI scientists collaborate with more than 250 research organizations worldwide.

DPI scientists work in a collaborative, team-based environment. The postdoctoral candidate will be recruited to work on the specific projects described below and will have ample opportunities to collaborate with scientists both within and outside of NCATS on additional projects. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Postdoctoral fellows also gain additional professional skills and exposure to a variety of career paths through participation in the DPI training program.

Postdoctoral Fellow (Neurotoxicologist), Genomic Toxicology Laboratory, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Genomic Toxicology Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applicants for a postdoctoral fellowship (neurotoxicologist) position in the Genomic Toxicology Laboratory in the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. Led by David L. Gerhold, Ph.D., this laboratory studies the effects of chemicals on human health as part of the Toxicology in the 21st Century (Tox21) program. The cutting-edge work focuses on early stages of the translational process, from target validation to running first-in-human studies. Researchers use novel human cellular 3-D and co-culture models to study diseases of the heart, kidney, and nervous system. DPI works closely with the 3-D Tissue Bioprinting program, Stem Cell Translational Laboratory, Therapeutics for Rare and Neglected Diseases program, and other NIH institutes and centers. DPI scientists also work with more than 250 academic and research organizations worldwide.

Core Responsibilities

The chosen candidate will work with Dr. Zhi-Bin Tong to use genomic tools in toxicology and pharmacology-related research projects in the Genomic Toxicology Laboratory. He or she also will focus on finding and classifying chemicals that cause or lead to neurological diseases, such as Parkinson’s or Alzheimer’s disease. Research in this laboratory has found likely pathways in neurons and led to a high-throughput screening method to locate chemical toxicants in chemical libraries (Tong et al. 2017, 2018, 2020, 2022). The fellow will describe the mechanisms of these neurotoxicants and will be able to work with scientists both within and outside of NCATS on toxicology, genomics and translational projects. The fellow will present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Postdoctoral fellows gain additional skills and are exposed to a variety of career paths through the DPI training program.

Qualifications

The ideal candidate should have a Ph.D. with a background in the fields of molecular or medical biology and a strong record of high-impact publications. Applicants should have skills in mammalian cell culture and data analysis. Applicants also should have strong oral and written English communication skills and be able to work in a team setting.

Applicants should be U.S. citizens or legal residents or should hold a valid work permit.

Stipends/Benefits

Annual stipends are based on experience and on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please send the following to NCATSGenomicTox@mail.nih.gov:

  • A cover letter describing your interest in the position
  • A current curriculum vitae and complete bibliography
  • Contact information for three references

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Chemical Biology/Molecular Pharmacology), Assay Development and Screening Technology Laboratory, Division of Preclinical Innovation

National Institutes of Health            
National Center for Advancing Translational Sciences            
Division of Preclinical Innovation            
Assay Development and Screening Technology Laboratory            
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral fellowship position within the Assay Development and Screening Technology (ADST) laboratory of James Inglese, Ph.D., within the center’s Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal chemists and computational scientists who work on a broad portfolio of preclinical drug discovery projects and with programs that involve developing innovative new technologies to enable the acceleration of biomedical research.

The ADST laboratory is interested in discovering and developing novel molecular modalities for a variety of therapeutic indications — including cancer — with particular emphasis on rare metabolic disease applications. The current focus is on the evaluation of antifolate-based proteolysis targeting chimera chemical libraries to define target profiles and underlying mechanisms of action. This research will involve the design and implementation of CRSIPR/Cas9 genome edited reporter cell lines to interrogate the molecular pharmacology and biochemical network of one-carbon metabolism using these chemical libraires. Compounds of interest will be characterized using proteomics and metabolomics analysis and, depending on their properties, assessed in synthetic lethality functional genomics and conditional combination drug screens. Candidate molecules displaying novel pharmacology will enter a collaborative therapeutic development program involving medicinal chemistry optimization accompanied by relevant in vivo cancer or relevant models associated with rare disorders.

Recent research from this laboratory relevant to the position can be found at https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00333-1.

For more information about the laboratory, see https://www.youtube.com/watch?v=VxtpySnbX-c and https://ncats.nih.gov/about/divisions-and-staff/jinglese.

Core Responsibilities

The successful applicant will have the opportunity to use an interdisciplinary approach to pursue research interests as they advance to an independent research career in the supportive intramural environment of the NCATS laboratories in Rockville, Maryland, which also includes core facilities specializing in automated high-throughput screening, synthetic organic chemistry, functional genomics, proteomics, advanced microscopy, biochemistry, human induced pluripotent stem cells, cheminformatics and bioinformatics.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have fewer than 3 years of postdoctoral experience in chemical biology, molecular pharmacology or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply. The selected candidate should be an independent thinker and team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and provide contact information for three references to James Inglese, Ph.D., at NCATS2024Postdoc@mail.nih.gov. Please direct questions regarding this position or the application process to Ms. Carrie Watkins at watkinsc@mail.nih.gov.

The review of applications will begin in spring 2024 and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Pharmacokinetics Modeling Postdoctoral Fellow, Division of Preclinical Innovation, Drug Metabolism and Pharmacokinetics Core

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Drug Metabolism and Pharmacokinetics Core                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional scientists for a postdoctoral fellow position in physiologically based pharmacokinetic (PBPK) modeling — for preclinical development projects involving drug metabolism and pharmacokinetics (DMPK) — within the center’s Division of Preclinical Innovation.

The DMPK Core partners with academic institutions, foundations and private industry to conduct preclinical discovery and development studies leading to Investigational New Drug (IND) applications for new therapeutics. These projects play a leading role in NCATS’ mission to develop new ways to reduce, remove or bypass bottlenecks across the continuum of translational science and address rare and neglected diseases.

Core Responsibilities

The selected candidate will collaborate with team members to conduct in vitro absorption, distribution, metabolism and elimination (ADME) and in vivo pharmacokinetic (PK) studies and develop PBPK models for assigned projects. Specific duties include independently performing in vitro ADME testing, conducting in vivo PK studies in laboratory animals, and developing PBPK models for NCATS drug development projects. These PBPK models will be used to guide the selection of lead drug candidates and predict human PK profiles prior to the clinical trials. The selected candidate will disseminate their research by publishing results in peer-reviewed journals and participating in scientific conferences and meetings.

Qualifications

Applicants to this postdoctoral fellow position should hold a Ph.D. in pharmaceutical science, pharmacology, pharmacokinetics or computer science — with a focus on drug development or a related life science field — and have a proven track record of in vitro and in vivo drug metabolism and pharmacokinetic studies. Applicants should possess excellent skills in quantifying novel drug molecules in serum/plasma or tissues and demonstrate solid knowledge in quantitative method development and data interpretation. Candidates with advanced knowledge and skills in high-performance liquid chromatography, mass spectrometry, in vitro ADME and PK studies, and computational modeling will receive preferential consideration.

The selected candidate should possess strong oral and written communication skills and excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner. The selected candidate will be expected to demonstrate a proven ability to collaborate with colleagues to achieve project, team and organizational goals.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your interest in the position, including a career synopsis (one to two pages), a current curriculum vitae with a complete bibliography, and provide contact information for at least three references to Xin Xu, Ph.D., at xin.xu3@nih.gov. The review of applications will begin on May 15, 2023, and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Biomedical Engineer), Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (biomedical engineer) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. The selected candidate should have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology and fluorescence microscopy, as well as experience working with primary cells or induced pluripotent stem cell-derived cells.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies, such as scRNA-seq — to develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including the architectural and physiological validation of tissues. Effective communication and presentation skills are required. The selected candidate will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed. The selected candidate must be eligible to work in the United States with NCATS collaborators worldwide.

Qualifications

Applicants to this postdoctoral position should possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in such areas as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology, and engineering of cells with biosensors — will be considered favorably.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for two to three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Molecular Biologist), Division of Preclinical Innovation, Therapeutic Development Branch, RNA Therapeutics Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
RNA Therapeutics Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (molecular biologist) position in the RNA Therapeutics Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. As a member of a dynamic, dedicated and multidisciplinary team of researchers committed to developing therapies for rare disorders, the selected candidate will work on innovative drug discovery projects to develop antisense oligonucleotide (ASO) therapies that can benefit patients and families affected by rare diseases.

Core Responsibilities

The selected candidate will be responsible for designing and developing 2-D and organoid assays to predict various types of toxicity (e.g., neurotoxicity, hepatotoxicity) associated with ASO therapies. The fellow will design and conduct experiments, analyze data, write reports and present research findings at scientific meetings and in peer-reviewed publications. The selected candidate also will collaborate with other members of the research team, as well as external partners, to advance the goals of the RNA Therapeutics Laboratory.

Qualifications

Applicants should have (or expect to receive) a Ph.D. in biochemistry, molecular biology or a related field at the time of joining the laboratory. The ideal candidate should be self-motivated, collaborative and team-orientated, with a strong work ethic and keen attention to detail. The candidate should possess strong oral and written communication skills and a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references to Bryan J. Traynor, M.D., Ph.D., at traynorb@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Systems Toxicology Postdoctoral Fellow, Division of Preclinical Innovation, Toxicology in the 21st Century (Tox21) Program

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Toxicology in the 21st Century (Tox21) Program                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral fellow position in the Toxicology in the 21st Century (Tox21) program within its Division of Preclinical Innovation. To meet the challenges of toxicology research in the 21st century, NCATS has partnered with the National Toxicology Program, the U.S. Food and Drug Administration and the U.S. Environmental Protection Agency to form the Tox21 program. Since 2010, this program has utilized a quantitative high-throughput screening approach to assess a 10,000-compound (10K) library using a group of biologically and toxicologically relevant in vitro assays. The data generated from the screening will be used to prioritize chemicals for further in-depth toxicological evaluation, identify mechanisms of chemical toxicity and develop predictive models for in vivo biological response in humans.

The selected postdoctoral fellow should be self-motivated and prepared to work on Tox21 research projects to develop physiologically relevant assays for assessment of environmental chemicals. NCATS provides a unique and exciting environment that employs state-of-art technologies enabling assay development, chemical screening and profiling for toxicology research.

Core Responsibilities

The postdoctoral candidate will develop in vitro cell-based assays using physiologically relevant cell models (primary cells, stem cell/ induced pluripotent stem cell-derived cells, and 3-D cell/organoid models) with biotransformation-capability for screening chemicals. The fellow will apply new technologies including 3-D cell/organoid models and high-content phenotypic profiling using cell-based imaging assays for evaluating chemical toxicity. The fellow will perform follow-up studies (e.g., mechanisms of compound action) after the primary screening. The fellow also will interact regularly with informatics scientists to aid data analysis and interpretation.

Qualifications

Applicants should hold a doctoral degree (M.D., Ph.D. or equivalent) in the life sciences (e.g., toxicology, pharmacology, biology, cell biology, biochemistry or a related field is preferred) with solid  understanding of toxicology, cell biology or general aspects of signal transduction. A strong preference will be given to applicants with prior experience in in assay development, including biotransformation-capable assays, imaging technology or compound screening. He or she should possess data analysis skills and familiarity with Excel spreadsheets. The applicant should possess strong oral and written communication skills, with a proven publication record in peer-reviewed journals. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and provide contact information for three references to Menghang Xia, Ph.D. at mxia@mail.nih.gov. Applicants also should indicate when they are available to start.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Biology Postdoctoral Position, Division of Preclinical Innovation, Early Translation Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Early Translation Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment within the ETB. He or she will use cutting-edge cell biology and bioassay technologies to develop disease-relevant screening assays and will be involved in all aspects of implementing small molecule screening programs, including assay design, assay development and optimization, high-throughput screening, data analysis, and mechanism-of-action studies to develop assay technologies and novel pharmacological probes.

Core Responsibilities

The postdoctoral candidate will need to have training in drug screening. This project includes the study of a new platinum agent for clinical development, along with an ambitious goal of screening and discovering new uses for platinum chemotherapeutic agents. The trainee will bring experience in cell biology or bioinorganic chemistry and learn to work in a team-based world-class drug discovery environment. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, bioinorganic chemistry, pharmacology, or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply; prior high-throughput screening experience is not a prerequisite. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and provide contact information for three references to NCATS ETB Careers at ncatsetbcareers@mail.nih.gov. Applicants also should indicate when they are available to start. Please note that the starting date of the fellowship is flexible, preferably within 2023.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Biology Postdoctoral Position, Division of Preclinical Innovation, Early Translation Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Early Translation Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment within the ETB. He or she will use cutting-edge cell biology and bioassay technologies to develop disease-relevant screening assays and will be involved in all aspects of implementing small molecule screening programs, including assay design, assay development and optimization, high-throughput screening, data analysis, and mechanism-of-action studies to develop assay technologies and novel pharmacological probes.

Core Responsibilities

The postdoctoral candidate will work on a project that includes the study of an understudied target class of enzymes, with the goal of SAR profiling the target class to promote probe development. Successful candidates will have a background in biochemistry, molecular biology, or cellular biology. Enzymology experience is preferred. Experience with drug screening and informatics are useful, but not required. The trainee will learn to work in a team-based world-class drug discovery environment. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, biochemistry, or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply; prior high-throughput screening experience is not a prerequisite. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and provide contact information for three references to NCATS ETB Careers at ncatsetbcareers@mail.nih.gov. Applicants also should indicate when they are available to start. Please note that the starting date of the fellowship is flexible, preferably within 2023.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Computational Toxicology/Informatics Postdoctoral Fellow Position, Division of Preclinical Innovation, Computational Toxicology Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Computational Toxicology Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a computational toxicology/informatics postdoctoral position in the Computational Toxicology Laboratory within the center’s Division of Preclinical Innovation (DPI). To meet the challenges of toxicology research in the 21st century, NCATS has formed a partnership  with the National Toxicology Program, the U.S. Food and Drug Administration, and the U.S. Environmental Protection Agency to develop a high-throughput screening (HTS) program. The goals of the Toxicology in the 21st Century (Tox21) program are to prioritize chemicals for further in-depth toxicological evaluation, identify mechanisms of chemical toxicity and develop predictive models for in vivo biological response in humans. NCATS has a unique and exciting environment that employs state-of-art technologies for assay development, chemical screening and profiling for toxicology research.

Core Responsibilities

The selected candidate will engage in several activities, including analyzing large data sets generated from HTS assays; developing novel methods to identify and prioritize toxicity response pathways for assay development and compound testing; building predictive models for different in vivo toxicity endpoints using chemical structural data, genomic data and in vitro assay data; and generating testable hypotheses on compound mechanisms of toxicity. The candidate should be familiar with public genomic and genetic databases and be capable of data mining using complex data sets. The successful candidate also should have experience building and integrating genomic databases and working at the interface of genomic and chemoinformatic information. The fellow will work closely with informatics scientists and biologists in the DPI to aid in data interpretation and project development.

Qualifications

Applicants to this position should possess a Ph.D. in the biomedical sciences, extensive experience with one or more programming languages, and knowledge in database queries and data retrieval. A background in cheminformatics or bioinformatics, biology, chemistry or toxicology is preferred. Experience in 2-D or 3-D modeling, large data set manipulation or data mining is a plus. The ideal candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for at least three references to Ruili Huang, Ph.D., at huangru@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Neuroscientist Postdoctoral Fellow Positions, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill neuroscientist postdoctoral fellow positions in the Division’s 3-D Tissue Bioprinting Laboratory. The selected candidates will develop human functional neural 3-D tissue models as assay platforms for the discovery and development of new therapeutics for pain, addiction or overdose. Applicants with a background in neurosciences, in vitro neural organotypic models and neural stem cells will receive preferential consideration.

Core Responsibilities

The selected candidates will work as part of a multidisciplinary team of innovative scientists with expertise in bioengineering, 3-D bioprinting, quantitative cell imaging, electrophysiology, histology, assay development, drug screening, data science and other cutting-edge “omics” technologies. The selected candidates will develop and characterize functional 3-D neural organotypic assays for drug discovery and development.

Qualifications

Applicants to these postdoctoral fellow positions should possess a Ph.D. in neuroscience, cell biology, molecular biology, pharmacology, pathology or a related discipline with relevant experience in neuroscience, physiology and pathology of the nervous system to help establish a portfolio of assays to model neural circuitry of pain, addiction and overdose. The ideal candidates will be expected to work independently as well-trained problem solvers in the production of 3-D neural organotypic models, including architectural and physiological validation, and develop functional assay readouts for drug screening. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Experience in techniques necessary to develop CNS and PNS assays for drug testing using tissues, including extracellular electrophysiological recording (field potential or multi-unit), calcium imaging, neural stem cell and primary cell culture and associated analysis is required. Experience with techniques such as histology, quantitative analysis of microscopy images, time-lapse microscopy is highly desired. Candidates with additional experience in physiology and pathology of pain, addiction or overdose, optogenetics microscopy, or tissue engineering or bioprinting techniques will receive preferential consideration. Each candidate should be an independent thinker and team player able to work and multitask in a highly interactive, fast-paced environment. The ideal candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information of at least three references to NCATSbioprinting@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Bioinformatics Position, Division of Preclinical Innovation, Informatics Core

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Informatics Core                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral bioinformatics position in the Informatics Core (IFX) within the Division of Preclinical Innovation.                           

The IFX is an interdisciplinary team of bioinformaticians, clinical informaticians, cheminformaticians and software engineers who collaborate closely with molecular biologists to augment the use of metabolomics and multi-omics analysis approaches to identify dysregulated pathways and putative therapeutic targets.

Core Responsibilities

The selected candidate — a postdoctoral fellow in bioinformatics — will have a solid foundation in bioinformatics and biostatistics, including machine learning, and experience in cleaning, processing, and integrating metabolomic and other -omic datasets. He or she will develop novel bioinformatics methods to optimize the predictive capacity of metabolomics and -omic (e.g., proteomic, transcriptomic) profiles in differentiating groups (e.g., cell characteristics, individuals). These novel approaches will augment the bioinformatics field by addressing issues not addressed by standard approaches. The selected candidate will interact closely with computational and noncomputational (e.g., biologists, chemists, clinicians) IFX and NCATS scientists and our academic collaborators. In addition to working independently on collaborative translational research projects, the fellow also would be involved in building a computational infrastructure for the QC, analysis and interpretation of metabolomic and multi-omic profiles. He or she will be expected to draft manuscripts and publish results in high-impact, peer-reviewed scientific journals and to present results at internal and external scientific meetings.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in bioinformatics, biomedical informatics, or a related field and have demonstrated hands-on experience in leading the large-scale analysis of multi-omic data. Experience with metabolomics data is strongly preferred. He or she should have demonstrated experience leveraging publicly available datasets, including their organization, cleaning and preprocessing. Applicants also should have demonstrated experience in multivariable analyses and machine/deep learning. Basic knowledge and understanding of biology and chemistry is a plus. Knowledge of R and/or Python and working within a high-performance computing/cloud environment is required.                           

The selected candidate should have excellent interpersonal, verbal and written communication skills in English and should possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. While the team is highly collaborative in nature, the pursuit of original computational research directions by the candidate is encouraged. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your career goals and interest in the position, including a research summary (one to two pages), a current curriculum vitae with a complete bibliography, and provide contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.                           

Application reviews will begin promptly and continue until the position is filled.

Learn more about informatics research at NCATS.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Biomedical Engineer Position, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral biomedical engineering position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation. The selected candidate should have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology, fluorescence microscopy and experience working with primary cells or induced pluripotent stem cell-derived cells.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies including scRNAseq — to develop advanced cellular models for drug discovery and development. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The selected applicants will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and present work to internal and external collaborators as needed. The selected candidates also must be eligible to work in the U.S. with whomever NCATS collaborates worldwide.

Qualifications

Each applicant to this postdoctoral position should possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in areas such as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology and engineering of cells with biosensors — will be considered favorably.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for two to three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Antibody Discovery and Characterization Position, Division of Preclinical Innovation, Early Translation Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Early Translation Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to hold a postdoctoral position in antibody discovery and characterization in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment and be exposed to cutting-edge high-throughput screening, assay biology, bioinformatics, medicinal chemistry and disease-relevant biological models. They will implement antibody discovery technologies (including phage display), directed evolution, and related technologies to produce and characterize antibodies relevant to diseases and conditions related to pain, addiction and overdose, and other public health emergencies, such as the SARS-CoV-2 pandemic. The selected applicant will apply cutting-edge cell biology and bioassay technologies for the development of disease-relevant antibody selection and screening assays and will be involved in all aspects of the implementation, including assay design, assay development and optimization, antibody screening, protein engineering, data analysis and mechanism-of-action studies.

Core Responsibilities

The selected candidate should be able to work independently under team supervision. The selected applicant will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports and manuscripts and will present work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, pharmacology or a related discipline. Experience with antibody phage display technologies — including panning, ELISA, and protein purification — and an understanding of antibody domain architecture are highly desirable. The candidate should be an independent thinker, a team player, and able to work in a very interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references to NCATSantibody_hiring@nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.

Application reviews will begin promptly and continue until the position is filled. 

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Genomic Toxicology Position, Division of Preclinical Innovation, Genomic Toxicology Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Genomic Toxicology Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral position and apply genomic tools to toxicology and pharmacology in the Genomic Toxicology Laboratory within the center’s Division of Preclinical Innovation (DPI). The Genomic Toxicology Laboratory, led by David L. Gerhold, Ph.D., participates in the Toxicology in the 21st Century (Tox21) program by developing methods to assess the effects of chemicals on human health, focusing on early stages of the translational process from target validation to first-in-human studies. This laboratory also develops novel human cellular 3-D and co-culture models to study cardiovascular disease, as well as neurological and renal diseases. DPI researchers collaborate closely with scientists in the 3-D Tissue Bioprinting Program, the Stem Cell Translational Laboratory, and the Therapeutics for Rare and Neglected Diseases program, as well as with other NIH institutes, centers and offices; and academic scientists. In addition to conducting cutting-edge laboratory research, DPI scientists work in a team-based environment and collaborate with more than 250 research organizations worldwide.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will complete the development and implementation of a novel high-throughput screening method that quantifies the expression of selected genes in cultured mammalian cells. The unprecedented throughput of this method will enable the screening of large chemical libraries of environmental toxicants or drug candidates. Because quantitative high-throughput screening of large chemical libraries is NCATS’ core expertise, the collaborative opportunities to apply this method to identify drug candidates and to screen Tox21 toxicant libraries are abundant. The successful applicant will work with collaborators who have developed induced Pluripotent Stem Cell (iPSC)–derived endothelial cells, as well as 3-D endothelial cell models that incorporate shear flow and co-culture with vascular smooth muscle cells. The postdoctoral candidate also will have opportunities to collaborate with scientists both within and outside of NCATS on additional projects. The selected candidate is expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals.

Qualifications

The ideal candidate will possess a doctoral degree (i.e., a Ph.D.) with a background in a relevant field of molecular or medical biology and have a strong record of high-impact publications. Applicants should possess molecular biology expertise and mammalian cell culture skills. Applicants also should possess strong oral and written English communication skills. Applicants with additional expertise in vascular biology or high-throughput screening will receive preferential consideration.

Applicants should be U.S. citizens or legal residents or should hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references to David L. Gerhold, Ph.D., at NCATSGenomicTox@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Mass Spectrometry Position, Division of Preclinical Innovation, Analytical Chemistry Core Facility

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Analytical Chemistry Core Facility                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation. The selected candidate should have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.

The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.

Core Responsibilities

The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

Qualifications

The successful applicant should possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a preferred. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable.

The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary (one to two pages); a current curriculum vitae with a complete bibliography; and provide contact information for at least three references to Christopher A. LeClair, Ph.D., at ncats_info@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Bioengineering Positions, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill postdoctoral bioengineering positions in the Division’s 3-D Tissue Bioprinting Laboratory. The selected candidates should have expertise in biofabrication, biomaterials or microfluidics to help establish a portfolio of functional, physiologically complex 3-D tissue models as predictive screening platforms for toxicity and efficacy drug testing. Applicants with additional expertise in microphysiological systems, immunology, neuroscience and production of induced pluripotent stem cell-derived cells will receive preferential consideration.

Core Responsibilities

The candidates will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies—including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other cutting-edge -omics technologies — to develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. They also will be expected to work independently as well-trained problem solvers in biofabrication and microfluidics, including on architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The successful candidates will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed.

Qualifications

Each applicant for this postdoctoral position should possess a Ph.D. in bioengineering, biomedical engineering, immunology, neuroscience, cell/molecular biology, pharmacology, pathology or a related discipline relevant to 3-D tissue models. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays—including work in such areas as organoids or biofabricated tissues, biomaterials, microfluidic systems, cell imaging, histology and engineering of cells with biosensors—as well as experience using bioprinting techniques, will be considered favorably. Candidates with a strong background in immunology and tissue engineering with induced pluripotent stem cell-derived cells are encouraged to apply. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter, a curriculum vitae with a complete bibliography, a one-page research proposal/plan for a physiologically complex 3-D tissues for disease modeling and compound testing, and provide the contact information for at least three references to NCATSbioprinting@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Computational Biologist/Bioinformatician, Division of Preclinical Innovation, Therapeutic Development Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral computational biologist/bioinformatician position in NCATS' Therapeutic Development Branch (TDB) within the Division of Preclinical Innovation.

TDB develops new systems, novel approaches and methodologies to achieve conceptual breakthroughs in preclinical therapeutics. The branch also provides collaborative access to technology and expertise in the scientific disciplines of early-discovery biology and medicinal chemistry; drug metabolism and pharmacokinetics; toxicology; and chemistry, manufacturing and controls synthesis and formulation.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will join an interdisciplinary team with a focus on profiling different cell types and responses in the context of rare genetic diseases, infectious diseases and drug treatments. He or she will be a bioinformatician/computational biologist with experience in bioinformatic analysis of NexGen sequencing datasets, with a strong emphasis in RNA-Seq analysis (bulk and single-cell). The fellow will collaborate with researchers in other universities and institutes and will learn preclinical drug development from colleagues in multidisciplinary project teams. The fellow should obtain extensive experience and skills in this training program that can be applied toward translational research for therapeutics development.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in biology, computer sciences, bioinformatics or a related discipline, with one to three years of relevant research experience. Candidates should possess strong computer programming skills in R and other required languages (e.g., Python/Perl, Java, C/C++). Experience analyzing bulk and single-cell RNA-Seq data sets is essential. The candidate also should possess strong self-motivational and problem-solving skills, as well as outstanding interpersonal and teamwork skills. Excellent analytical, organizational and time management skills are required. Experience with proteomics data sets also is preferred, but not necessary. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position; a current curriculum vitae with a complete bibliography; and provide contact information for three references to Wei Zheng, Ph.D., at NCATSTDBBioHiring@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Informatics Scientist, Division of Preclinical Innovation, NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group                           
Rockville, Maryland

Description

NCATS is one of the 27 institutes and centers at NIH. The Informatics group collaborates closely with biologists and chemists to develop robust assay designs, analyze experimental outcomes and validate new hypothesis. NCATS’ informatics personnel perform a variety of ligand- and protein structure-related modeling tasks, support the drug discovery process and accelerate translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.

NCATS’ Informatics group seeks a creative, self-motivated postdoctoral informatics scientist to develop new algorithms for prediction of i) protein-ligand interactions; ii) chemical reactions and comprehensive support of drug discovery projects.

Core Responsibilities

The postdoctoral fellow will be responsible for uploading and analyzing pilot and quantitative high-throughput screening runs; analyzing assay reproducibility; analyzing confirmation and secondary screening assays; developing and applying QSAR models and molecular modeling for virtual screening of compounds; supporting medicinal chemistry efforts; and developing new algorithms for prediction of protein-ligand interactions and chemical reactions. Research will be conducted by NCATS' Informatics group.

Qualifications

The ideal candidate will possess a minimum of a Ph.D. in computational science/bioinformatics with specialization in machine learning. He or she will have published at least three research articles as first author. The successful candidate should have experience with common cheminformatics libraries and data formats (e.g., RDKit, OpenBabel, SMILES, InChi, etc.), modern software packages (e.g., MOE/CCG, OpenEye tools) and scientific programming (e.g., Python, JAVA) and data analytics (e.g., KNIME, Spotfire). He or she should be able to script work flows and implement new algorithms, have experience working with multi-disciplinary teams, and possess strong oral and written English communication skills. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras), as well as experience in developing algorithms for prediction of protein-ligand interactions and/or chemical reactions.

Applicants should be U.S. citizens or legal residents or should hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in this position, a current curriculum vitae with a complete bibliography to Alexey V. Zakharov, Ph.D., at alexey.zakharov@nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Stem Cell Scientist and Postdoctoral Positions, Division of Preclinical Innovation, Chemical Genomics Branch, Stem Cell Translation Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Chemical Genomics Branch                           
Stem Cell Translation Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from qualified candidates with expertise in developmental biology and human induced pluripotent stem cells (iPSCs) to fill stem cell scientist and postdoctoral positions in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as iPSCs, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems. Successful candidates will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS, external service providers and collaborators at top academic institutions.

Core Responsibilities

The selected candidates will join a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, compound management, automation engineering, bioinformatics, medicinal chemistry and various -omics technologies. They will work in a highly creative environment, focusing on important aspects of human pluripotency and cellular differentiation using cutting-edge technologies (e.g., single-cell analysis, deep sequencing, robotic cell culture, high-throughput electrophysiology, genome editing). They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Qualifications

Each applicant should possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Exceptional candidates with master’s degrees and strong backgrounds in stem cell biology will be considered. Candidates with experience in drug discovery, cell and tissue engineering, cell signaling, or quantitative biology are encouraged to apply. The ideal candidates should be team players with high scientific standards and have the ability to work in an interactive, fast-paced environment. They should be self-motivated to learn new technologies and be familiar with the methods and concepts of stem cell biology and regenerative medicine.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and provide contact information for three references to NCATSstemcellhiring@mail.nih.gov.

Application reviews will begin promptly and continue until the position is filled.

Additional Information

A preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents) may determine employment after an offer has been made and accepted.

At your supervisor’s discretion, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.


Last updated on July 15, 2024