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Invention E-041-2010/0

Small Molecule Neuropeptide S (NPS) Antagonists for the Treatment of Addictive Disorders, Mood and Anxiety Disorders, and Sleep Disorders

Lead Inventor: Juan Marugan (NCATS)
Inventors: Markus Heilig (NIAAA), Ke Liu (NHGRI), Samarjit Patnaik (NCATS), Noel Southall (NCATS), Wei Zheng (NCATS)
Ref. No.: E-041-2010/0

Abstract: The inventors have developed NPSR antagonists that hold the potential for being clinically useful treatments for alcohol and drug addiction.

Publications:

A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in RatsJournal of Neuroscience • June 12, 2013 • Probe Development Branch, NCATS Chemical Genomics Center

Neuropeptide S Facilitates Cue-Induced Relapse to Cocaine Seeking Through Activation of the Hypothalamic Hypocretin SystemPNAS • Nov. 9, 2010 • Probe Development Branch, NCATS Chemical Genomics Center

Selective Modulation of Gq/Gs Pathways by Naphtho Pyrano Pyrimidines as Antagonists of the Neuropeptide S ReceptorACS Chemical Neuroscience • Aug. 18, 2010 • Probe Development Branch, NCATS Chemical Genomics Center

Last updated: 07-21-2016
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