Small-Molecule Modulators of Lipid Storage for Treatment of Obesity, Atherosclerosis,
Metabolic Syndrome and Lipid Storage Diseases
Lead Inventor: Matthew Boxer (NCATS)
Ref. No.: E-277-2011/0
Abstract: Lipid droplets are key organelles involved in lipid homeostasis. In normal physiology, these droplets are formed in response to elevated fatty acid levels, and are broken down when needed for energy production. Imbalances in lipid homeostasis trigger compensatory alterations in metabolism that can lead to diseases such as obesity, atherosclerosis, and metabolic syndrome.