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Pfizer's Centers for Therapeutic Innovation for NIH Researchers

Therapeutic Areas of Interest

For the most recent call for proposals, Pfizer was interested in research projects that fell within the following therapeutic areas:

Oncology

Targets/pathways that:

  • Enhance antitumor immune responses alone or in combination with standard of care.
  • Enhance immune surveillance (e.g., tumor neoAg recognition).
  • Target unique aspects of tumor or TME metabolic activity.
  • Exploit vulnerabilities in tumor heterogeneity, senescence or plasticity.
  • Promote or enable tumor-selective or -specific drug delivery or targeting.

Inflammation and Immunology

Targets/pathways that:

  • Regulate tissue-specific immune cell activation or function.
  • Exploit immune cell or lineage-specific metabolic pathways.
  • Modulate inflammation and/or tissue remodeling and repair in the context of liver fibrosis (nonalcoholic fatty liver disease [NAFLD]/nonalcoholic steatohepatitis [NASH]).
  • Promote gut epithelial barrier health and integrity.
  • Regulate antigen-specific tolerance induction and/or modulate T regulatory cells.

Cardiovascular and Metabolic Diseases

Targets/pathways that:

  • Reverse hepatic steatosis associated with NAFLD/NASH.
  • Inhibit lipolysis to treat NAFLD/NASH.
  • Reverse cachexia experienced by patients with cancer or chronic diseases, such as heart failure, chronic kidney disease and chronic obstructive pulmonary disease.
  • Reverse muscle insulin resistance in patients with type 2 diabetes mellitus.
  • Improve heart failure by specifically correcting defects in cardiac metabolism.

Rare Diseases

Targets/pathways that:

  • Represent novel targets for nonmalignant hematologic indications, including sickle cell disease and complement mediated diseases.
  • Address skeletal and cardiac muscle diseases, including Duchenne or Becker muscular dystrophies.
  • Treat repeat expansion diseases, including Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia and myotonic dystrophy.

Learn more about each of these therapeutic areas of interest.