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Pre-clinical research toolbox

Assay Guidance Workshop Agenda - October 2016

Thursday, October 27, 2016 – 8:30 a.m. – 5:30 p.m. (CT)

Promega Feynman Center, Room 112, 2780 Woods Hollow Road, Madison, WI 53711

8:30 – 8:50 a.m.: Robust or Go Bust: An Introduction to the Assay Guidance Manual

8:50 – 9:35 a.m.: Strategies for Selecting Assays and the Development of Robust Biochemical Assays
Nathan P. Coussens, Ph.D., NCATS, NIH

9:45 – 10:30 a.m.: Treating Cells as Reagents to Design Reproducible Screening Assays
Terry Riss, Ph.D., Promega Corporation

10:40 – 11:00 a.m.: Coffee Break

11:00 – 11:45 a.m.: Assay Development for High Content Screening
O. Joseph Trask, Jr., Ph.D., PerkinElmer

11:55 – 12:45 p.m.: Working Lunch (Boxed lunches provided)

12:45 – 1:15 p.m.: Avoiding Assay Artifacts and Interferences
G. Sitta Sittampalam, Ph.D., NCATS, NIH

1:20 – 1:50 p.m.: Assay Interference by Chemical Reactivity
Jayme L. Dahlin, M.D., Ph.D., Brigham and Women's Hospital

1:55 – 2:40 p.m.: Basic Assay Statistics, Data Analysis and Rules of Thumb
Thomas D.Y. Chung, Ph.D., Mayo Clinic

2:50 – 3:00 p.m.: Coffee Break

3:00 – 3:45 p.m.: Reproducibility and Differentiability of Compound Potency Results from Screening Assays in Drug Discovery
V. Devanarayan, Ph.D., AbbVie Inc.

3:55 – 4:40 p.m.: Assay Operations: Keeping your Assays Robust and Reproducible
Jeffrey R. Weidner, Ph.D., AbbVie Inc.

4:50 – 5:30 p.m.: Small Group Discussions

Acknowledgements: Chris Austin, Neal Cosby, Nicholas Gelardi, Nicole Haselwander, Michael Hoffmann, Sandy Ismail, Terry LaMotte, Cindy McConnell, Melvin Reichman, Laura Richards, Hannah Scott, Stephanie Shea, Anton Simeonov, and Geoff Spencer