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Pre-clinical research toolbox

Assay Guidance Workshop Agenda — August 2017

Monday, August 7, 2017 — 8:00 a.m.–5:40 p.m. ET

William F. Bolger Center, 9600 Newbridge Drive, Potomac, Maryland 20854

8:00 – 8:15 a.m.: Welcome: An Introduction to the Assay Guidance Manual
Christopher P. Austin, M.D., NCATS, NIH

8:15 – 9:05 a.m.: Strategies for Assay Selection and the Development of Robust Biochemical Assays
Nathan P. Coussens, Ph.D., NCATS, NIH

9:05 – 9:55 a.m.: Treating Cells as Reagents to Design Reproducible Screening Assays
Terry Riss, Ph.D., Promega Corporation

9:55 – 10:05 a.m.: Beverage Break

10:05 – 10:55 a.m.: Assay Development for High-Content Screening
O. Joseph Trask, Jr., Ph.D., PerkinElmer, Inc.

10:55 – 11:45 a.m.: Assay Interpretation: Studies in Mechanisms and Methods in Assay Interferences
Douglas Auld, Ph.D., Novartis Institutes for BioMedical Research

11:45 a.m. – 1:00 p.m.: Lunch

1:00 – 1:50 p.m.: Assay Interference by Chemical Reactivity
Jayme L. Dahlin, M.D., Ph.D., Brigham and Women’s Hospital

1:50 – 2:40 p.m.: Basic Assay Statistics, Data Analysis and Rules of Thumb
Thomas D.Y. Chung, Ph.D., Mayo Clinic

2:40 – 3:30 p.m.: Reproducibility and Differentiability of Compound Potency Results from Screening Assays in Drug Discovery
V. Devanarayan, Ph.D., AbbVie, Inc.

3:30 – 3:40 p.m.: Beverage Break

3:40 – 4:30 p.m.: Avoiding Assay Artifacts and Interferences in Assay Operations
G. Sitta Sittampalam, Ph.D., NCATS, NIH

4:30 – 5:20 p.m.: In Vitro Toxicological Testing Using a qHTS Platform
Menghang Xia, Ph.D., NCATS, NIH

5:20 – 5:40 p.m.: Closing Remarks
Anton Simeonov, Ph.D., NCATS, NIH