Matrix Screening Scientific Capabilities

NCATS’ combination screening experts use an automated platform capable of screening thousands of drug combinations each week. Compound libraries include approved drugs, agents currently under clinical evaluation and high-value tool compounds. Researchers can apply combination screening to varied cell-based phenotypic assays ranging from simple viability assessments to more complex high-content studies.

The NCATS robotic combination screening platform takes advantage of an existing high-throughput screening foundation as well as several core enhancements:

  • Mechanism interrogation plates library of pharmacologically defined small molecules for high-precision combination screening of known-mechanism compounds
  • Acoustic dispensing technology provided by EDC Biosystems
  • A custom Web-based interface for data analysis and access to results