NCATS’ combination screening experts use an automated platform capable of screening thousands of drug combinations each week. Compound libraries include approved drugs, agents currently under clinical evaluation and high-value tool compounds. Researchers can apply combination screening to varied cell-based phenotypic assays ranging from simple viability assessments to more complex high-content studies.
The NCATS robotic combination screening platform takes advantage of an existing high-throughput screening foundation as well as several core enhancements:
- Mechanism interrogation plates library of pharmacologically defined small molecules for high-precision combination screening of known-mechanism compounds
- Acoustic dispensing technology provided by EDC Biosystems
- A custom Web-based interface for data analysis and access to results