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Matrix Combination Screening

Matrix Screening Method

NCATS experts implemented and improved the matrix combination screening method to help researchers more quickly identify the best drug combinations. The method includes three major steps described below.

Step 1: Generate single agent results:

Single agent screening results

 

Step 2: Generate 6×6 matrix data to uncover potential synergies among agents:

6x6 plot of matrix screening results

 

Step 3: Expand good combinations to 10×10 blocks to confirm synergistic combinations and perform self-cross analyses to provide context for activities:

10x10 plot of matrix screening results

Last updated: 07-25-2017
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