NCATS experts implemented and improved the matrix combination screening method to help researchers more quickly identify the best drug combinations. The method includes three major steps described below.
Step 1: Generate single agent results:
Step 2: Generate 6×6 matrix data to uncover potential synergies among agents:
Step 3: Expand good combinations to 10×10 blocks to confirm synergistic combinations and perform self-cross analyses to provide context for activities: