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Primary screening system Arms 1 and 3 on the Primary screening system are working simultaneously on parallel processes. Microtiter plates are loaded onto the necessary devices, an operation is performed per the associated protocol and they are returned to the original storage location. |
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Acoustic compound dispense and assay detection protocols running simultaneously Multiple plates are acoustically dispensed with nanoliters of chemical compounds. Shows robotic arm 1 unloading assay and chemical compound source plates from incubator and storage hotel respectively, removing the metal lids and placing onto the acoustic dispenser. This also includes the robotic arm retrieving the plates once finished, replacing lid and loading back into storage locations. In the background arm 3 is also working to process plates for an assay detection protocol. Credit: NCATS |
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Assay detection protocol using arm 3 of Primary screening system 1536-well assay plates containing cells and chemical compounds are being loaded onto a solenoid valve low volume liquid dispenser, after the metal lid is removed, which is adding microliters of a detection reagent into every well. The lid is then put back on and the assay plate is loaded into a storage hotel for incubation. The final step in the protocol is removing the lid and loading the plate into the multimode reader to collect the resultant data. Credit: NCATS |
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Automated tissue culture robot and Arm 1 of Primary screening system In the background the automated tissue culture platform is running a process where you see the arm within going through specific steps. Simultaneously arm 1 of the Primary screening system is unloading the assay plate as well as the chemical compound acoustic source plate into their respective locations. Credit: NCATS |
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Acoustic dispense and plate unload/load Nanoliters of a library of chemical compounds are dispensed using acoustic energy into a 1536-well assay plate. Once it finishes the dispense the lifter presents the plate and the robotic arm unloads the current plate, replaces the metal lid and returns it to the incubator. The next assay plate in the queue is loaded onto the acoustic dispenser after the lid is removed by the robotic arm. Credit: NCATS |
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End of cell splitting protocol Cells added into a new flask, returned to incubator and pipette disposed of by robotic arm. |
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Automated tissue culture robot Reagents are being dispensed and emptied from a cell flask as part of an automated cell splitting process run on the system which also includes removing and replacing the flask cap as needed and perturbing to wash flask inner surface thoroughly. Credit: NCATS |
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Plate incubator carousel rotating Assay plate incubator carousel is rotating and shows the 1536-well white microtiter plates with metal lids to prevent evaporation stored within. |
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Acoustic chemical compound dispense
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Tox21 robot b-roll B-roll of the high-speed robot screening system for the Toxicology in the 21st Century initiative. |
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NCATS Chemical Genomics Center (right-to-left pan) Right-to-left pan of the front of the NCATS Early Translation Branch’s chemical genomics production line showing chemical prep area, incubator and library carousel of compounds. |
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Three Tox21 robots (extreme wide shot) A tilt-down wide shot showing three yellow robot arms moving plates in the testing production line. |
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Front of production line (extreme wide angle) A wide angle establishing a shot of the front of the production line. |
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Robots two and three working (medium shot) A medium shot of robots two and three moving plates along the production line. |
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Two robots moving (medium shot) Medium tilt-down shot of robots one and two moving plates along the production line. |
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Multiple plates moving (wide shot) Wide shot, from an angle, of two robots moving plates along the production line. |
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Two robots exchanging plates (wide shot) Wide shot, from the side, showing two robots moving plate across transfer platform. |
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Transfer plate (extreme close-up) Extreme close-up of a transfer plate. |
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Tilt-down feeding the detector (close-up) Close-up tilt-down shot of a robot arm placing a reaction plate on a detector that measures the reactions. |
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Microfluidics pipetting machine (extreme close-up to wide shot) Extreme close-up pulls back show a microfluid pipetting machine that puts chemicals in plates. |
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Robot feeding stacking rack (wide shot with pan) Wide shot of a robot arm moving a plate to a stacking rack. |
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Control panel (wide shot) Wide shot of the control panel for the production line with a robot arm moving in the background. |
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Chemistry station (wide shot) Wide shot of the chemistry station where chemicals are mixed and added to the pipeline with the robot moving in the background. |
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Molecular libraries (wide shot) Static wide shot showing the molecular libraries end of the production line with a library carousel rotating. |
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Two robots feed microfluidics system (medium shot) Medium shot of two robots moving plates across the transfer station in front of a fluid-handling system. |
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Molecular library carousel (medium shot) Medium shot of the molecular library carousel rotating to make volumes available to production line. |
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Fluid handling (wide shot) Wide shot of the fluid supply and handling end of the production line. |
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Technician cleaning sensor (wide shot) Medium, over-the-shoulder shot of a technician cleaning the sensor on a bench-top lab machine. |
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Technician cleaning plates (wide shot) Wide shot of a technician removing reaction plates from tray and cleaning them on a lab bench. |
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Technician laying out plates (wide shot to medium shot) Wide shot of a technician laying out plates on lab bench, with a zoom in to a medium shot as he cleans the plates. |
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Technician cleaning many plates (extreme close-up) Extreme close-up of a technician cleaning reaction plates on a lab bench. |
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