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An NCATS scientist prepares samples for high-throughput screening. (Daniel Soñé Photography, LLC, Photo)

Finding What’s Common Among Diseases, Seeing the Bigger Picture

NCATS scientists are identifying common characteristics among diseases and applying this knowledge to understand multiple human diseases and conditions.


Dorian Cheff holds a well plate in NCATS’ laboratory.

NCATS Ignites Translational Science Spark for Young Investigators

Meet three graduate students working collaboratively on research projects with NCATS and university scientists from England and Sweden.


Researchers determine the amount of exosomes in cancer cells.

Repurposed Drug Approach May Thwart Spread of Cancer Cells

NCATS pre-clinical staff helped NIH Extracellular RNA Communication program-supported scientists use a new approach to find drugs that may help prevent the spread of prostate cancer.


Work with Us

NCGC is highly collaborative and always encourages new partnership opportunities, including projects with NIH and external researchers as well as disease foundations and biotechnology companies. Learn more about how to work with us.

NCATS Chemical Genomics Center (NCGC)

NCGC researchers advance small molecule therapeutic development through assay (test) design, high-throughput screening and medicinal chemistry. Learn more.

Find NCATS Programs & InitiativesAccess NCATS Expertise & Resources

About NCGC

Find out more about how NCGC experts help discover novel small molecule therapies across the spectrum of human diseases.

Scientific Capabilities

Access a collaborative team of experts in assay development, high-throughput screening, medicinal chemistry, informatics and drug development.

Work with NCGC

Learn how to collaborate with NCGC staff to pursue a drug target or screen of interest.

Looking for a chemical probe?

NCGC experts have developed many small molecule probes for further therapeutic development.

Unique NCGC Team Structure

NCGC is composed of three drug discovery teams, each with dedicated biologists, chemists and informatics scientists. These teams are uniquely designed to handle small molecule discovery efforts, including early assay optimization, state-of-the-art high-throughput screening, early hit selection, advanced medicinal chemistry driven by structure-activity relationships, virtual screening, and molecular modeling and docking. Each team showcases specialized areas of expertise to cover a wide spectrum of biological targets and human pathologies. Learn more about the teams.