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Scientists identified a compound, TRi-1, that can kill cancer cells and reduce tumor growth. These images compare tumors treated with a compound that has no effect (top two rows) to tumors treated with the anticancer compound TRi-1 (bottom two rows). The images on the bottom row indicate the TRi-1-treated tumors are mostly smaller after three days of treatment.

NCATS, Karolinska Institutet Scientists Attack Cancer’s Defenses

Scientists from NCATS and Sweden’s Karolinska Institutet have developed a potential new approach to fighting cancer by breaking down a defense system used by cancer cells.

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NCATS Chemical Genomics Center (NCGC)

NCGC researchers advance small molecule therapeutic development through assay (test) design, high-throughput screening and medicinal chemistry. Learn more.

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Find out more about how NCGC experts help discover novel small molecule therapies across the spectrum of human diseases.

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      Unique NCGC Team Structure

      NCGC is composed of three drug discovery teams, each with dedicated biologists, chemists and informatics scientists. These teams are uniquely designed to handle small molecule discovery efforts, including early assay optimization, state-of-the-art high-throughput screening, early hit selection, advanced medicinal chemistry driven by structure-activity relationships, virtual screening, and molecular modeling and docking. Each team showcases specialized areas of expertise to cover a wide spectrum of biological targets and human pathologies. Learn more about the teams.