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Cancer liver

Team Develops Potential New Approach to Stop Cancer Metastasis

NCATS scientists collaborated with NCI and Northwestern University researchers to identify a new compound that blocks the spread of several types of cancer in animal models.

Anticancer cells on a laptop

NCATS, Karolinska Institutet Scientists Attack Cancer’s Defenses

Scientists from NCATS and Sweden’s Karolinska Institutet have developed a potential new approach to fighting cancer by breaking down a defense system used by cancer cells.

huntington cells

NCATS-Led Team Finds Potential Strategy to Fight Huntington’s Disease

A team of NCATS scientists and collaborators have uncovered a potential strategy against Huntington’s disease that may also be relevant to a range of neurodegenerative disorders.

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NCGC is highly collaborative and always encourages new partnership opportunities, including projects with NIH and external researchers as well as disease foundations and biotechnology companies. Learn more about how to work with us.

NCATS Chemical Genomics Center (NCGC)

NCGC researchers advance small molecule therapeutic development through assay (test) design, high-throughput screening and medicinal chemistry. Learn more.

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About NCGC

Find out more about how NCGC experts help discover novel small molecule therapies across the spectrum of human diseases.

Scientific Capabilities

Access a collaborative team of experts in assay development, high-throughput screening, medicinal chemistry, informatics and drug development.

Work with NCGC

Learn how to collaborate with NCGC staff to pursue a drug target or screen of interest.

Looking for a chemical probe?

NCGC experts have developed many small molecule probes for further therapeutic development.

Unique NCGC Team Structure

NCGC is composed of three drug discovery teams, each with dedicated biologists, chemists and informatics scientists. These teams are uniquely designed to handle small molecule discovery efforts, including early assay optimization, state-of-the-art high-throughput screening, early hit selection, advanced medicinal chemistry driven by structure-activity relationships, virtual screening, and molecular modeling and docking. Each team showcases specialized areas of expertise to cover a wide spectrum of biological targets and human pathologies. Learn more about the teams.