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Discovering New Therapeutics Uses for Existing Molecules

New Therapeutic Uses Funding Information

NIH-Industry Partnerships

NIH launched the NIH-Industry Partnerships initiative in May 2012 as part of the Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses) program. By pairing researchers with a selection of pharmaceutical industry assets, this innovative program aims to test ideas for new therapeutic uses, ultimately identifying promising new treatments for patients.

Bench-to-Clinic Repurposing

In October 2017, NCATS released a funding opportunity to explore a potential new use of an existing drug or biologic. Through the Bench-to-Clinic Repurposing initiative, NCATS will support pre-clinical studies to test the utility of an independent crowdsourcing effort or computational algorithm to predict new uses of an existing drug or biologic. 

Current Opportunities

NCATS has released the following funding opportunity announcements:

  • PAR-18-332: Clinic Testing Therapeutic/Indication Pairing Strategies (U01 Clinical Trial Required)
  • PAR-17-465: Bench Testing Therapeutic/Indication Pairing Strategies (UG3/UH3)
    • NOT-TR-17-022: Notice of Modification to PAR-17-465 "Bench Testing Therapeutic/Indication Pairing Strategies (UG3/UH3)"

Technical Assistance Slides for NIH-Industry Partnerships (PDF -387KB)

Expired Announcements

These expired funding announcements include details on the application process, eligibility and timelines for the program:

  • RFA-TR-17-001: Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)​
  • RFA-TR-17-002: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UG3/UH3)
  • RFA-TR-17-003: Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UG3/UH3)
  • NOT-TR-17-015: Changes to FOA RFA-TR-17-001 "Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)"
  • X02 Pre-Application Frequently Asked Questions
  • RFA-TR-16-015: Bench Testing Therapeutic/Indication Pairing Strategies (UH2/UH3)
  • PA-16-183: Limited Competition: Rare Diseases Clinical Research Network (RDCRN) Project Supplements for Clinical Trials to Repurpose Drugs in Collaboration with E-Rare Awardees (Admin Supp)
  • RFA-TR-16-001: Pre-clinical Research Based on Existing Repurposing Tools (R21)
  • NOT-TR-15-008: Notice of Clarification Regarding Clinical Trial Documentation Requirements for New Therapeutic Uses Investigators
  • PAR-14-210: Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • PAR-14-211: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH3)
  • PAR-14-212: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • PAR-14-213: Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)
  • NOT-TR-14-001: Notice to Solicit Compounds for Inclusion in the NIH-Industry New Therapeutic Uses Program
  • NOT-TR-12-010: Technical Assistance Webinar for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules Limited Competition RFA-TR-12-004 (UH2/UH3) and RFA-TR-12-005 (UH3)
  • NOT-TR-12-008: Clarification for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules PAR-12-203 (X02) Pre-Application, and Limited Competition RFA-TR-12-004 (UH2/UH3) and RFA-TR-12-005 (UH3)
  • PAR-12-203: A Pre-application for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (X02)
  • RFA-TR-12-004: Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • RFA-TR-12-005: Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH3)
Last updated: 11-08-2017
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