New Therapeutic Uses Funding Information

NIH-Industry Partnerships

NIH launched the NIH-Industry Partnerships initiative in May 2012 as part of the Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses) program. By pairing researchers with a selection of pharmaceutical industry assets, this innovative program aims to test ideas for new therapeutic uses, ultimately identifying promising new treatments for patients.

Bench-to-Clinic Repurposing

NCATS has released a set of funding opportunities to explore a potential new use of an existing investigational therapy, Food and Drug Administration-approved drug, or licensed biologic. Through the Bench-to-Clinic Repurposing initiative, NCATS will support pre-clinical studies, clinical feasibility studies or proof-of-concept clinical trials to test the utility of an independent crowdsourcing effort or computational algorithm to predict new uses of a drug or biologic.

Current Opportunities

NCATS has released the following funding opportunity announcements:

  • Industry Partners
    • PAR-18-910: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (U01 Clinical Trial Required)
    • PAR-18-909: Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02 Clinical Trial Not Allowed)
      • NOT-TR-18-032: Notice of Change to Receipt Date on Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02 Clinical Trial Not Allowed) (PAR-18-909)
  • Bench to Clinic
    • PAR-18-462: Clinical Trial Planning: Therapeutic/Indication Pairing Strategies (U34) (Clinical Trial Not Allowed)
    • PAR-18-332: Clinic Testing Therapeutic/Indication Pairing Strategies (U01 Clinical Trial Required)
    • PAR-17-465: Bench Testing Therapeutic/Indication Pairing Strategies (UG3/UH3)
      • NOT-TR-18-016: Notice of Change in Bench Testing Therapeutic/Indication Pairing Strategies (UG3/UH3) (PAR-17-465)
      • NOT-TR-17-022: Notice of Modification to PAR-17-465 "Bench Testing Therapeutic/Indication Pairing Strategies (UG3/UH3)"

Expired Announcements

These expired funding announcements include details on the application process, eligibility and timelines for the program:

  • RFA-TR-17-001: Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)​
  • RFA-TR-17-002: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UG3/UH3)
    • NOT-TR-17-014: Changes to RFA-TR-17-002 "Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UG3/UH3)"
  • RFA-TR-17-003: Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UG3/UH3)
    • NOT-TR-17-013: Changes to RFA-TR-17-003: Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UG3/UH3)
  • NOT-TR-17-015: Changes to FOA RFA-TR-17-001 "Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)"
  • RFA-TR-16-015: Bench Testing Therapeutic/Indication Pairing Strategies (UH2/UH3)
  • PA-16-183: Limited Competition: Rare Diseases Clinical Research Network (RDCRN) Project Supplements for Clinical Trials to Repurpose Drugs in Collaboration with E-Rare Awardees (Admin Supp)
  • RFA-TR-16-001: Pre-clinical Research Based on Existing Repurposing Tools (R21)
  • NOT-TR-15-008: Notice of Clarification Regarding Clinical Trial Documentation Requirements for New Therapeutic Uses Investigators
  • PAR-14-210: Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • PAR-14-211: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH3)
  • PAR-14-212: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • PAR-14-213: Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)
  • NOT-TR-14-001: Notice to Solicit Compounds for Inclusion in the NIH-Industry New Therapeutic Uses Program
  • NOT-TR-12-010: Technical Assistance Webinar for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules Limited Competition RFA-TR-12-004 (UH2/UH3) and RFA-TR-12-005 (UH3)
  • NOT-TR-12-008: Clarification for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules PAR-12-203 (X02) Pre-Application, and Limited Competition RFA-TR-12-004 (UH2/UH3) and RFA-TR-12-005 (UH3)
  • PAR-12-203: A Pre-application for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (X02)
  • RFA-TR-12-004: Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • RFA-TR-12-005: Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH3)