HHS Logo U.S. Department of Health & Human Services Divider arrow NIH logo National Institutes of Health Alt desc
Skip Over Navigation Links

2016 Bench-to-Clinic Repurposing Projects

In the fall of 2016, NCATS issued 11 Bench-to-Clinic Repurposing awards. The funded pre-clinical projects will serve as “use cases” to demonstrate the utility of an independent crowdsourcing effort or a computational algorithm to predict new therapeutic uses of an existing drug or biologic.


Institution & Principal Investigator

Repurposing Misoprostol for Clostridium Difficile Colitis as Identified by PheWAS

Vanderbilt University Medical Center: David M. Aronoff, M.D.

Repurposing Lesogaberan for the Treatment of Type 1 Diabetes

University of California, Los Angeles: Daniel L. Kaufman, Ph.D.

Ketorolac and Related NSAIDs for Targeting Rho-family GTPases in Ovarian Cancer

University of New Mexico Health Sciences Center: Angela Wandinger-Ness, Ph.D.

Pre-Clinical Evaluation of a Neutrophil Elastase Inhibitor for the Treatment of Inflammatory Bowel Disease

Beth Israel Deaconess Medical Center: Efi Kokkotou, M.D., Ph.D., D.Sc

CXCR2 Antagonism in the Immunometabolic Regulation of Type 2 Diabetes

Allegheny-Singer Research Institute: Nick Giannoukakis, Ph.D.

Repurposing Pyronaridine as a Treatment for the Ebola Virus

Collaborations Pharmaceuticals, Inc.: Sean Ekins, Ph.D., D.Sc. (contact); Robert A. Davey, Ph.D.

Anti-Virulence Drug Repurposing Using Structural Systems Pharmacology

Hunter College: Lei Xie, Ph.D.

Quantum Model Repurposing of Cethromycin for Liver Stage Malaria

Johns Hopkins University: David J. Sullivan, M.D.

Network-Driven Drug Repurposing Approaches to Treat Coronary Artery Disease

Icahn School of Medicine at Mount Sinai: Chiara Giannarelli, M.D., Ph.D. (contact); Johan M. Bjorkegren, M.D., Ph.D.

Drug Repositioning in Diabetic Nephropathy

University of California, San Francisco: Minnie M. Sarwal, M.D., Ph.D.

Therapeutic Repurposing of Benserazide for Colon Cancer

University of Texas Medical Branch at Galveston: Csaba Szabo, M.D., Ph.D.

Last updated: 11-08-2017
▲ Back to top