NIH investigators are eligible to collaborate with the RNAi program at NCATS and access screening facility resources. Genome-wide siRNA screens for humans and mice are available. Also routinely included in screens are microRNA mimic and inhibitor libraries.
The RNAi program provides in-kind resources in the form of screening support for NIH investigators whose proposals are accepted following internal Institute or Center review as well as a trans-NIH review committee’s approval to proceed. Rejected proposals can be revised to address key concerns and resubmitted for additional review. Following acceptance, the NIH principal investigator and NCATS staff work together to develop a project plan and begin work.
For more information, review the latest version of the assay guidance manual.