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RNA Interference

RNAi Projects

RNAi projects at NCATS span a wide range of diseases and fundamental biological processes.

Selected Active Projects

Project Areas


  • Drug enhancer/resistance screens
    • DNA-damaging agents
    • Immunotoxins
  • Molecular targets in cancer
    • Breast cancer
    • Melanoma
  • Cancer-related pathways
    • NF-κB
    • Migration

Infectious diseases

  • Viral infection and replication
    • Poxvirus
    • HIV
    • Ebola virus
    • Hepatitis C virus
  • Immune response

Fundamental cell biology

  • DNA replication
  • Reprogramming/differentiation

Other disease-related phenotypes

  • Parkinson’s disease
  • Diabetes
  • Fragile X syndrome