Staff Profile: William F. Borschel

William F. Borschel
William F. Borschel, Ph.D.

Research Scientist

Division of Preclinical Innovation
Therapeutic Development Branch (Contractor)

National Center for Advancing Translational Sciences

National Institutes of Health

Email William F. Borschel

Biography

William F. Borschel joined NCATS in 2020 as a research scientist in the Therapeutic Development Branch within the Division of Preclinical Innovation. Borschel operates the electrophysiology laboratory, supporting projects across the Center’s entire intramural research program.

Prior to joining NCATS, Borschel started his postdoctoral training as a research fellow in the laboratory of Colin G. Nichols, Ph.D., at Washington University School of Medicine in St. Louis, where he investigated lipid regulation of potassium channels to understand the molecular mechanism of hyperinsulinemia. Borschel finished his postdoctoral training in the laboratory of Seok-Yong Lee, Ph.D., at Duke University School of Medicine. In Lee’s laboratory, his research focused on the biophysical basis of the temperature sensitivity of thermally activated ion channels involved in chronic and inflammatory pain.

Borschel received his doctorate in biochemistry from the University at Buffalo, where he investigated the biophysical mechanism of ionotropic glutamate receptor desensitization under the mentorship of Gabriela K. Popescu, Ph.D.

Research Topics

Borschel’s research focuses on investigating new therapeutic development for opioid addiction, overdose and pain management. He collaborates with biologists, identifying and validating drug targets that modulate neuronal excitability and synaptic transmission associated with addiction and chronic pain using electrophysiological methods. Borschel also develops and validates probes and lead drug candidates in primary neurons and brain tissues, as well as human-induced pluripotent stem cell-derived neurons, organoids and bioprinted tissues. He also develops electrophysiological assays to determine neuronal toxicity of new drug candidates.

Selected Publications

  1. Regulatory Switch at the Cytoplasmic Interface Controls TRPV Channel Gating
  2. Cryo-Electron Microscopy Structure of the Lysosomal Calcium-Permeable Channel TRPML3
  3. Control of Kir Channel Gating by Cytoplasmic Domain Interface Interactions
  4. Gating Reaction Mechanism of Neuronal NMDA Receptors