Staff Profile: Samuel A. Bozzette

Samuel A. Bozzette, M.D., Ph.D.

Chief Medical Officer

Office of Translational Medicine

National Center for Advancing Translational Sciences

National Institutes of Health

Email Samuel A. Bozzette


Samuel A. Bozzette is the chief medical officer within NCATS' Office of Translational Medicine, where he monitors the Center’s clinical research activities. He also serves as a principal advisor to the director and others across NCATS in developing strategies to advance therapeutics development and clinical research initiatives.

Prior to joining NCATS, Bozzette was the chief scientist at Premier Inc., a health services company, where he managed a 50+ person research group conducting both retrospective and prospective studies. Previously, he held leadership positions at bioMérieux, a French diagnostics company; at Cerner, a biomedical informatics company; at Amylin Pharmaceuticals, a biopharmaceutical company; and at a consultancy serving industry and government. Prior to his aforementioned industry experience, Bozzette spent 15 years in academia at the VA San Diego Healthcare System; the University of California, San Diego’s School of Medicine and school of international relations, and the RAND Corporation. In addition to research, teaching and clinical activities, he was a division chief and led programs in health services research and in public policy and biological threats. He has authored more than 175 articles, chapters and reports, including over a dozen in The New England Journal of Medicine. Bozzette has received many awards and distinctions, including the “Paper of the Year Award” from the Association for Health Services Research for The care of HIV-infected adults in the United States. HIV Cost and Services Utilization Study Consortium and Variations in the care of HIV-infected adults in the United States: results from the HIV Cost and Services Utilization Study. He has been a member of many national and international advisory panels, has chaired an NIH Special Emphasis Panel and has served on several others.

Bozzette holds a bachelor’s degree from Georgetown University, a medical degree from the University of Rochester School of Medicine, and a doctorate in policy analysis from the Pardee RAND Graduate School. He is certified in internal medicine and infectious diseases and is a fellow of both the American College of Physicians and the Infectious Diseases Society of America. He is also an elected member of the American Society for Clinical Investigation and the Association of American Physicians.

Research Topics

As an academic, Bozzette was interested primarily in comprehensive treatment and health services evaluations across the translational spectrum. His focus was on efficacy, effectiveness and adoption of treatments for HIV and threat organisms, but he also was interested in evaluation methods, per se, including new approaches to assessing efficacy, effectiveness, patient-reported outcomes and dissemination/implementation. During that time, Bozzette participated in various leadership committees of the AIDS Clinical Trials group at the National Institute of Allergy and Infectious Diseases, as well as other cooperative study programs and collaboratories. In recent years, he has led groups conducting outcomes studies, including retrospective, real-world, big-data projects and prospective implementation projects for a wide range of diseases.

Selected Publications

  1. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. California Collaborative Treatment Group
  2. Health status and function with zidovudine or zalcitabine as initial therapy for AIDS. A randomized controlled trial. Roche 3300/ACTG 114 Study Group
  3. Participation in research and access to experimental treatments by HIV-infected patients
  4. A model for a smallpox-vaccination policy
  5. Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection