Staff Profile: Lu Chen

Lu Chen, Ph.D.
Lu Chen, Ph.D.

Staff Scientist

Division of Preclinical Innovation
Functional Genomics Lab

National Center for Advancing Translational Sciences

National Institutes of Health

Email Lu Chen


Lu Chen joined NCATS in 2015 as an informatics research scientist in the Division of Preclinical Innovation (DPI). He is currently the informatics leader of the Functional Genomics Lab (FGL) and provides leadership for RNAi/CRISPR-Cas9 screening for functional genomics projects. In addition to serving as the informatics leader of the FGL program, Chen is also involved in methodological development in various cheminformatics, chemical genomics and assay automation projects within the DPI. He analyzes large data sets obtained from high-throughput screenings and builds mathematical models to understand pharmacological synergisms (or antagonisms) when multiple drugs are combined. He helped to create and also maintains the NCATS Matrix Client to support the Center’s Matrix Combination Screening program. In 2020, he participated in a drug combination repurposing campaign (SARS-CoV-2 cytopathic effect) to fight against COVID-19 pandemic

Chen earned his B.S. in biological sciences from Fudan University and his Ph.D. in experimental therapeutics from The University of Texas Health Science Center at Houston.

Research Topics

Chen’s recent work has focused on developing a flexible RNAi/CRISPR-Cas9 screening platform as well as robust statistical tools, such as RNAi off-target analysis, for functional genomic studies. He is also developing novel algorithms for assay quality control, bias correction and synergy identification for NCATS’ combination screening platform.

Selected Publications

  1. A Multiprotein Supercomplex Controlling Oncogenic Signalling in Lymphoma
  2. Characterization of Clinically Used Oral Antiseptics as Quadruplex-Binding Ligands
  3. Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma
  4. Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma
  5. mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening