Staff Profile: Yu “Robin” Chen

Yu “Robin” Chen, Ph.D.

Scientist, Stem Cell Translation Laboratory (Contractor)

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

Email Yu “Robin” Chen

Biography

Yu “Robin” Chen is a scientist in the Stem Cell Translation Laboratory within the Division of Pre-Clinical Innovation at NCATS. Chen works on optimizing cell culture protocols for the maintenance and differentiation of human embryonic stem cells and induced pluripotent stem cells (iPSCs) and on developing stem cell-based assays for quantitative high-throughput screening. Prior to joining NCATS, Chen conducted his postdoctoral work at the Eunice Kennedy Shriver National Institute of Child Health and Human Development’s Cell Biology and Neurobiology Branch, where he focused on understanding the molecular mechanisms of protein sorting in the endosomal-lysosomal system by using quantitative proteomics, molecular and cellular biology, biochemistry, and advanced imaging techniques.

Research Topics

Chen is interested in developing robust and scalable protocols for the maintenance and differentiation of iPSCs for high-throughput screening assays and clinical applications.

Selected Publications

  1. Segregation in the Golgi complex precedes export of endolysosomal proteins in distinct transport carriers.
  2. TSSC1 is novel component of the endosomal retrieval machinery.
  3. BORC coordinates encounter and fusion of lysosomes with autophagosomes.
  4. EARP is a multisubunit tethering complex involved in endocytic recycling.
  5. Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis.