Biography
Yogita Jethmalani is a postdoctoral fellow in the Stem Cell Translation Laboratory within NCATS’ Division of Preclinical Innovation, where she works with induced pluripotent stem cells (iPSCs) to advance their use in clinical applications by enhancing and standardizing the cell culture protocol. Replacing expensive recombinant proteins with small-molecule reagents can optimize the cell differentiation protocol, aiding its use in therapy.
Jethmalani earned her doctorate in biological sciences from the University of Maryland, Baltimore County, where she worked in the Department of Biology under Erin Green, Ph.D. Her research in the field of epigenetics focused on understanding the regulation of chromatin landscape at telomeres by a stress-response protein, which is key in understanding the chromatin regulation in different types of cancer and neurodevelopmental disorders. Jethmalani obtained her Bachelor’s degree and Master of Science in biotechnology from the University of Mumbai in India.
Research Topics
Jethmalani is interested in developing innovative and robust protocols for the differentiation of iPSCs for use in clinical applications, such as cell therapy and high-throughput screening. Her goals are to increase her professional knowledge and training while at NCATS and then obtain a leadership role to further benefit society through smart science. Jethmalani hopes to contribute to the advancement of stem cell therapy into the clinic.
Selected Publications
- Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells
- Set4 Regulates Stress Response Genes and Coordinates Histone Deacetylases Within Yeast Subtelomeres
- Set4 Is a Chromatin-Associated Protein, Promotes Survival During Oxidative Stress, and Regulates Stress Response Genes in Yeast
- Using Yeast to Define the Regulatory Role of Protein Lysine Methylation
- Human Dental Pulp Stem Cells: Applications in Future Regenerative Medicine