Stephen C. Kales joined NCATS in June 2014 as a biologist. Drawing on his diverse background in biological systems, Kales collaborates to develop a rich target portfolio, including projects in oncology, neurobiology and epigenetics. Born and raised in Canada, Kales received his Ph.D. in biology from the University of Waterloo before joining the National Cancer Institute (NCI) as a research fellow. During his time at NCI’s Women’s Malignancies Branch and Laboratory of Cellular and Molecular Biology, Kales investigated the role of novel mutations and protein-protein interactions on growth factor receptor signaling complexes in solid tumor development.
Kales enjoys the collaborative research environment and project diversity at NCATS. With his colleagues in biology, chemistry and bioinformatics, he strives to build productive, long-term collaborations with researchers from academia, government, industry and beyond. His current screening and drug repurposing projects span a wide range of target areas, including:
- Epigenetics (histone acetyltransferases and demethylases)
- Ubiquitin proteasome system
- Tumor suppressor function
- Oncoprotein destabilizers
- Transcription factors
- Kinase inhibitors