Staff Profile: Stephen C. Kales

Stephen C. Kales, Ph.D.

Research Scientist (Biology)

Division of Preclinical Innovation
Early Translation Branch (Contractor)

National Center for Advancing Translational Sciences

National Institutes of Health

Email Stephen C. Kales


Stephen Kales joined NCATS in 2014 as a biologist within the Division of Preclinical Innovation. Drawing from his diverse background in biological systems, Kales collaborates to develop a rich target portfolio, including projects in oncology, neurobiology and epigenetics.

Prior to joining NCATS, Kales was a research fellow with the National Cancer Institute, where he investigated the role of novel mutations and protein-protein interactions in growth factor receptor signaling in solid tumor development.

Kales received his doctorate in biology from the University of Waterloo in Canada, where he applied a variety of molecular techniques to study immune function and host-pathogen interactions.

Research Topics

Kales enjoys the collaborative research environment and project diversity at NCATS. With his colleagues in biology, chemistry, informatics and engineering, he strives to build productive collaborations with researchers from academia, government and industry. His current high-throughput screening and repurposing projects span a wide range of target areas, including the areas covered in the following publications:

Selected Publications

  1. KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations
  2. KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
  3. Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A
  4. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2
  5. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds