Staff Profile: David W. Kim

David Kim, Ph.D.

Research Scientist (Medicinal Chemistry)

Division of Pre-Clinical Innovation
Early Translation Branch (Contractor)

National Center for Advancing Translational Sciences

National Institutes of Health

Email David Kim

Biography

David Kim joined NCATS in 2014 as a medicinal chemist working under Juan J. Marugan, Ph.D., on the Thymine Team within the Division of Pre-Clinical Innovation. Kim currently works on several medicinal chemistry projects focusing on small-molecule modulators against proteins of interest, including G protein-coupled receptors, lipid kinases and lysosomal enzymes. Working in collaboration with other NIH Institutes and Centers and academic groups, the Thymine Team aims to better understand the role of disease in bone homeostasis, infectious agents, cancer and lysosomal disorders. 

Kim started his career with the Schering-Plough Corporation in Kenilworth, New Jersey, in 2005. He worked on several medicinal chemistry projects, including the development of glucan synthase inhibitors for antifungal treatment, diacylglycerol acyltransferase inhibitors for diabetes treatment, and adenosine 2a antagonists for the treatment of Parkinson’s disease. In 2012, Kim subsequently worked for the Albany Molecular Research Institute, on an in-sourcing collaboration with Eli Lilly and Company, prior to joining NCATS.

Kim earned his bachelor’s degree in chemistry from Emory University in 1996, his master’s degree in chemistry from the Georgia Institute of Technology in 2000, and his doctorate in synthetic organic chemistry from the University of California, San Diego, under Professor K.C. Nicolaou in 2005, where he completed the total synthesis of (-) Apicularen A and Halipeptin D. 

Research Topics

  • Thyroid-stimulating hormone receptor for bone homeostasis
  • Relaxin receptor I for cancer treatment
  • PI4K2a for treatment of infectious diseases
  • Galactocerebrosidase for treatment of Krabbe disease

Selected Publications

  1. A large scale high throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.
  2. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.
  3. Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
  4. Total synthesis of halipeptins A and D and analogues.
  5. Stereocontrolled total synthesis of apicularen A and its delta(17,18) Z isomer.