Staff Profile: Dmitriy V. Krepkiy

Dmitriy V. Krepkiy
Dmitriy V. Krepkiy, Ph.D.

Program Officer

Office of Special Initiatives

National Center for Advancing Translational Sciences

National Institutes of Health

Email Dmitriy V. Krepkiy


Dmitriy Krepkiy is a program officer in NCATS’ Office of Special Initiatives, where he oversees the NIH-wide Tissue Chip for Drug Screening program. In this capacity, he serves as a liaison between funded investigators, NIH administrative and program management staff, and external collaborators. These collaborators include the U.S. Food and Drug Administration, the National Aeronautics and Space Administration, the Defense Advanced Research Projects Agency, other U.S. Department of Health and Human Services agencies, and representatives from the pharmaceutical industry.

Prior to joining NCATS in November 2022, Krepkiy was a program director in the Biomedical Technology Branch of the Division of Biophysics, Biomedical Technology, and Computational Biosciences at the National Institute of General Medical Sciences (NIGMS). In this position, he oversaw technology development grants, national facilities, biomedical technology research resources, and Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants. Krepkiy also was the NIGMS SBIR/STTR coordinator. Before his tenure at NIGMS, Krepkiy was a staff scientist at the National Institute of Neurological Disorders and Stroke, where he worked on ion channels involved in neurological diseases.

Krepkiy earned his doctorate in chemistry from the University of Wisconsin–Milwaukee, studying transcription factors. He conducted postdoctoral research at the Medical College of Wisconsin, where he worked on kinases, and at the National Institute on Alcohol Abuse and Alcoholism, where he focused on G-protein-coupled receptors.

Research Topics

Krepkiy is interested in technologies to facilitate drug discovery for various classes of drug targets. He serves as a liaison between public and private scientific entities to develop the use and regulation of tissue chips to accelerate drug development.

Selected Publications

  1. Engineering Vanilloid-Sensitivity Into the Rat TRPV2 Channel
  2. Structural Insights Into the Mechanism of Activation of the TRPV1 Channel by a Membrane-Bound Tarantula Toxin
  3. Structure and Hydration of Membranes Embedded With Voltage-Sensing Domains
  4. Bacterial Expression of Functional, Biotinylated Peripheral Cannabinoid Receptor CB2
  5. Identification of Active Site Residues in Mevalonate Diphosphate Decarboxylase: Implications for a Family of Phosphotransferases