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Staff Profile: Anju Singh

Anju Singh, Ph.D.
Anju Singh, Ph.D.

Research Scientist, Biology (Contractor)

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

E-mail Anju Singh

Biography

Anju Singh joined the NCATS Division of Pre-Clinical Innovation in 2012 as a research scientist in biomolecular screening and probe development. She received a Ph.D. in immunology at the University of Wisconsin–Madison, where she worked under M. Suresh, D.V.M., M.V.Sc., Ph.D., on regulating memory CD8 T-cell differentiation during viral infections. As a postdoctoral fellow in the laboratory of Laurie Glimcher, M.D., at Harvard University, Singh studied anabolic regulators of bone mass and stem cell biology of the skeletal system.

Research Topics

Singh is interested in the use of small molecules for immunomodulation. Her research interests include:

  • Regulating helper T-cell differentiation and plasticity, especially in characterizing potential therapeutic compounds that inhibit pathogenic Th17 cells and suppress autoimmunity.
  • Developing immune activators to increase cytotoxic T-cell function, particularly during cancers, immunodeficiencies and infectious diseases.
  • Developing in vitro disease models using induced pluripotent stem cells derived from patients and multiple cell-type models for diseases affecting multiple systems.
  • Osteoimmunology, an emerging field that focuses on understanding the complex interactions between the immune and skeletal systems and on developing novel therapies for diseases affecting both systems.

Singh has extensive experience in implementing high-throughput screens and using many assay technologies, from cell-based reporter gene assays and multiplex gene expression assays to flow cytometry. She also has knowledge and expertise in in vivo animal models and in high-throughput screening using primary cells.

Selected Publications

  1. Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties.
  2. Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.
  3. p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory.
  4. Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1.
  5. Indirect regulation of CD4 T-cell responses by tumor necrosis factor receptors in an acute viral infection.