Dan Talley joined NCATS in 2016 as a postdoctoral researcher on a medicinal chemistry team led by Juan J. Marugan, Ph.D. In 2018, Talley moved to a research scientist position under the direction of chemistry team leader Ganesha Rai Bantukallu, Ph.D.
Talley focuses on identifying flawed biological pathways common to multiple diseases/disorders and on developing small-molecule modulators to restore cellular homeostasis and function. This often involves medicinal chemistry optimization of hit compounds, usually identified via quantitative high-throughput screening and/or machine learning, and employing pharmacophore-based screening and quantitative structure-activity relationship studies. He also has significant experience in developing and synthesizing small-molecule probes for target deconvolution and mechanism of action studies. In addition, Talley works to site-specifically and stoichiometrically modify human Immunoglobulin Gs for subsequent versatile conjugation to payloads, including small-molecule probes or drugs, fluorescent and near-infrared dyes, peptides, and other antibodies.
Talley received his bachelor’s degree in biochemistry from Salisbury University and his doctorate in organic chemistry from the University of Maryland, Baltimore County.
- Rabies virus
- Modulators of endoplasmic reticulum dislocation
- Hepatitis C virus
- Niemann-Pick disease type C
- Platforms for drug delivery and localization
- Antibody conjugation