HHS Logo U.S. Department of Health & Human Services Divider arrow NIH logo National Institutes of Health Alt desc
Skip Over Navigation Links
Staff banner

Staff Profile: Yuhong Wang

Yuhong Wang

Informatics Scientist (Contractor)

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

E-mail Yuhong Wang

Biography

Yuhong Wang received a B.S. in geochemistry from the University of Science and Technology of China in 1984 and a master’s degree in bioorganic chemistry from the Shanghai Institute of Organic Chemistry in 1987. He was a fellow at the University of Michigan in computational chemistry in 1992–1993 and at the University of Georgia in 1994–1995.

Research Topics

Wang’s primary research interests include algorithm development in structural biology, bioinformatics and cheminformatics. He also is interested in climate science as well as system design and implementation for large-scale biological and chemical databases.

Selected Publications

  1. A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
  2. Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.
  3. A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.
  4. Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
  5. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.