Staff Profile: Yuhong Wang

Yuhong Wang

Scientist

Division of Pre-Clinical Innovation
Informatics (Contractor)

National Center for Advancing Translational Sciences

National Institutes of Health

Email Yuhong Wang

Biography

Yuhong Wang received a B.S. in geochemistry from the University of Science and Technology of China in 1984 and a master’s degree in bioorganic chemistry from the Shanghai Institute of Organic Chemistry in 1987. He was a fellow at the University of Michigan in computational chemistry in 1992–1993 and at the University of Georgia in 1994–1995.

Research Topics

Wang’s primary research interests include algorithm development in structural biology, bioinformatics and cheminformatics. He also is interested in climate science as well as system design and implementation for large-scale biological and chemical databases.

Selected Publications

  1. The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics.
  2. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
  3. The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity.
  4. A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
  5. Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.