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Spinal cord neurons and brain blood vessel cells interact on a tissue chip.

Tissue Chips Help Uncover Clues to How Cells “Talk” to Each Other

NIH-supported researchers at Cedars-Sinai have used stem cells and 3-D tissue chips to mimic conditions in the development of the human spinal cord.

John Wikswo, Ph.D., and Ronald Reiserer

NCATS Supports Award-Winning Technology for Drug Development

To address challenges in drug development, NCATS supported research on a device designed to make the pre-clinical drug testing process more efficient and reliable.

Work With Us

The Tissue Chip for Drug Screening program is designed to improve the way new drugs are developed and tested. Learn more about how you can join this effort.

Contact Danilo Tagle, Ph.D. (link sends e-mail)

Tissue Chip for Drug Screening

The Tissue Chip for Drug Screening program aims to develop bioengineered devices to improve the process of predicting whether drugs will be safe or toxic in humans. Learn more.

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About Tissue Chip

Read more about the Tissue Chip program and its goal to create 3-D organs-on-chips for drug safety and efficacy testing.

Tissue Chip Funding Information

Find more information about how the Tissue Chip program funds innovative research.

Tissue Chip Facts

Download the Tissue Chip fact sheet (PDF - 337KB).

Why Tissue Chips Matter

Approximately 30 percent of promising medications have failed in human clinical trials because they are determined to be toxic — despite promising pre-clinical studies in animal and cell models. Tissue chips are a newer, human cell–based approach to this challenge. The chip devices may enable scientists to predict more accurately how effective a therapeutic candidate would be in clinical studies.

Eliminating toxic and/or ineffective drugs earlier in the development process would save time and money. These human tissue chips also could teach us a great deal about disease progression, enabling researchers to better prevent, diagnose and treat disorders. Learn more about the Tissue Chip for Drug Screening program.

Watch the Tissue Chip for Drug Screening video to learn more about the program. The media player works best when viewed in Chrome or Internet Explorer browsers.