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Discovering New Therapeutic Uses for Existing Molecules

Scientist working in a laboratory
Drug Development Collaboratory (UG3/UH3 Clinical Trial Required)

This funding opportunity announcement supports intramural-extramural collaborations on late-stage translational science projects between NCATS Therapeutic Development Branch and extramural researchers.

Crystal McKnight examines a compound source plate.
Urgent Phase I/II Clinical Trials to Repurpose Existing Therapeutic Agents to Treat COVID-19 Sequelae (U01 Clinical Trial Required)

This urgent funding opportunity announcement invites applications to repurpose existing therapeutic agents to treat COVID-19 sequelae and associated complications that result from SARS-CoV-2 infections.

Work with Us

Learn more about how you can access funding and collaborate with the New Therapeutic Uses program.

Bobbie Ann Mount, Ph.D.

New Therapeutic Uses Facts

Therapeutic development is a costly, complex and time consuming process. The average length of time from target discovery to approval of a new drug is about 14 years. The failure rate during this process exceeds 95 percent, and the cost per successful drug can be $1 billion or more. The high therapeutic development failure rate means there are many existing, partially developed therapeutic candidates that could be repurposed for use in new disease indications.Learn more about the New Therapeutic Uses program through the fact sheet (PDF - 395KB).