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Kelli M. Wilson, Ph.D.

Acting Director of Compound Management

Division of Preclinical Innovation

Information Technology Resources Branch

Research Services Core

Contact Info

Kelli M. Wilson, Ph.D.


Kelli Wilson is the acting director of the Compound Management group in the Information Technology and Research Branch, Research Services Core, within NCATS’ Division of Preclinical Innovation (DPI), where she focuses on collaboration with NCATS scientists who require compounds for screening and other translational science projects. Her role involves compound acquisition, automation and liquid handling process development and consultation for various specialized projects. Additionally, she leads multiple projects related to data science and data-sharing initiatives within DPI.

Wilson joined NCATS in 2014 as a postdoctoral fellow under Craig J. Thomas, Ph.D. In this capacity, she conducted research projects using NCATS’ drug combination screening platform to find novel therapies for various cancer indications. These successful projects resulted in initiation of a clinical trial for a marizomib and panobinostat combination therapy for diffuse intrinsic pontine glioma patients (NCT04341311) and collaborations with clinicians using the combination of M6620 with topotecan to treat small cell lung cancer (NCT0248709). Additionally, Wilson’s data science projects have focused on sharing NCATS screening data with various partners (e.g., the National Cancer Institute) to facilitate further research.

Wilson earned her doctorate in cellular and molecular medicine from The Johns Hopkins University School of Medicine and her Bachelor’s degree in biological sciences from North Carolina State University. Her doctoral research focused on using patient-derived brain tumor cell lines for high-throughput screening to find novel therapeutics for glioblastoma.

Research Topics

Wilson’s research is focused on compound acquisition, annotation and distribution in support of NCATS’ scientific staff; novel drug combination therapies for oncology indications; and assay annotation and data sharing.

Selected Publications

  1. Therapeutic Strategies for Diffuse Midline Glioma From High-Throughput Combination Drug Screening
  2. Therapeutic Targeting of ATR Yields Durable Regressions in Small Cell Lung Cancers With High Replication Stress
  3. Overcoming Adaptive Therapy Resistance in AML by Targeting Immune Response Pathways
  4. Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy
  5. Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2