June 15 – July 31, 2020
Enhance your translational science skills this summer with a seven-week online course, MEDI 501: Principles of Preclinical Translational Science.
This course has reached capacity for Summer 2020. To receive an invitation to register for the Fall 2020 course when registration opens in July, please add your name to the course’s waitlist.
An Engaging Case Study Teaching Approach
Translational science is an emerging field that seeks to identify broadly generalizable scientific and operational principles to enhance the effectiveness and efficiency of translational research. In this course, students will learn preclinical translational science principles.
Faculty will teach these principles through a case study of a highly successful translational research partnership involving NCATS, the National Cancer Institute, Northwestern University and the University of Kansas. The partnership produced a promising potential drug shown to inhibit metastasis in animal models, which is being examined in a first-in-human clinical trial in 2020.
Time Requirement and Costs
This one-credit course requires a time commitment of about one hour per week to listen to course lectures and some additional time to complete course readings and other short assignments. It is being offered as a pilot course, with a reduced fee of $50.
- Understand the definitions and goals of translational research and translational science and how they differ.
- Identify a range of scientific and operational principles that can be applied to enhance preclinical translational research projects.
- Learn about the research process necessary to enable a scientific discovery to produce an effective compound that can be used in humans.
- Learn about the varied roles of different disciplines, as well as agencies — including industry, government agencies, and academic faculty and institutions — in advancing translational research and how to facilitate effective interagency and team-based partnerships.
Who Should Participate?
- Individuals at all career stages—from students to senior scientists—and across a variety of roles, including scientists, administrators and experts in scientific collaboration
- Individuals interested in exploring translational science as a research area or career path
- Individuals interested in learning scientific, operational and partnership principles for effective translational research that can be applied to their own work
- Faculty involved in translational science education and training programs
Download the course flyer (PDF - 334KB) for additional details.
Read the course syllabus (PDF - 126KB), including links to faculty bios.
July 7–8, 2020
Day 1: 8:30 a.m. to 5 p.m. ET
Day 2: 8:30 a.m. to 4:30 p.m. ET
The schedule and format of this workshop are under revision. Please check back for updates.
The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) and the Center for Biologics Evaluation and Research (CBER) at the U.S. Food and Drug Administration (FDA) are co-hosting a virtual Workshop on Systemic Immunogenicity Considerations for Adeno-Associated Virus (AAV)-Mediated Gene Therapy. This meeting will bring together scientists, therapeutic developers and patient representatives to focus on immunogenicity issues related to the systemic administration of AAV gene therapy products and identify solutions for those issues.
Goals for this meeting are to—
- Exchange lessons learned from AAV gene therapy clinical trials to date, including clinical manifestations of immunogenicity, methods for evaluating the risk of immune responses, effective immunosuppressive protocols and other clinical topics.
- Explore emerging methods and technologies for modulating immune responses to AAV gene therapies with respect to both reducing the immunogenicity of AAV vector molecules and tolerizing strategies.
- Review basic, preclinical and clinical knowledge gaps, including the adequacy of current in-silico algorithms, preclinical models, assays and knowledge-sharing mechanisms to address those gaps.
- Identify and explore potential solutions.
This listing will be updated as more information becomes available.
Sept. 17, 2020
Closed Session: 10-11 a.m. ET
Open Session: 11:30 a.m. to 5 p.m. ET
The NCATS Advisory Council will convene a virtual meeting on Sept. 17, 2020. The meeting will feature presentations by NCATS leadership and invited guests. For more information about the Advisory Council, visit the NCATS Advisory Council page of this site.