- NCATS Advisory Council and CAN Review Board Meeting
- NCATS Toolkit for Patient-Focused Therapy Development: Demonstration and Dissemination Meeting
- Translational Medicine 2017: Enhancing Predictivity in Medicines Development
- Workshop on Translational Challenges of Induced Pluripotent Stem Cells
Sept. 7, 2017
8:30 a.m. to 5 p.m. ET
National Institutes of Health (Main Campus)
Building 31C, 6th Floor, Conference Room 6
Bethesda, Maryland 20892
The NCATS Advisory Council and Cures Acceleration Network Review Board will convene a joint meeting on Sept. 7, 2017, on the NIH campus in Bethesda, Maryland. The meeting will feature presentations by NCATS leadership and invited guests. NCATS staff will present proposed initiative concepts for Advisory Council/CAN Review Board consideration. For more information about the Advisory Council and CAN Review Board, visit the NCATS Advisory Council page and the Cures Acceleration Network Review Board page of this site.
Sept. 8, 2017
9 a.m. to 4 p.m. ET
National Institutes of Health Main Campus (Main Campus)
William H. Natcher Building (Building 45)
Conference Center Auditorium
Bethesda, Maryland 20892
NCATS urges the patient community to save the date for this meeting to officially launch the NCATS Toolkit for Patient-Focused Therapy Development online resource portal. Patients, their caregivers and patient-support organizational representatives are invited to attend to learn how the toolkit can streamline the search for the right tools to help in their therapeutic development activities. Participants also will have the opportunity to provide input into how the toolkit can be expanded and made more useful.
Since early 2016, NCATS has been working with a diverse group of partners in the rare diseases community to conduct an extensive landscape analysis of available tools and to define, characterize and organize them in a centralized portal that should be helpful to all patient groups regardless of how far along the research and development continuum they might be. These tools include:
- How to establish a patient registry;
- How to drive patient-focused discovery and pre-clinical research and development;
- How to work with NIH and the Food and Drug Administration; and
- How to conduct post-market surveillance.
Sept. 24―26, 2017
Prague 4, 140 69
NCATS Director Christopher P. Austin, M.D., will deliver a keynote address on Tuesday, Sept. 26, 2017, during the “Developing More Predictive Preclinical Tools to Better Reach Proof of Concept” plenary session of Translational Medicine 2017. This third biannual conference, organized by the European Advanced Translational Research Infrastructure in Medicine (EATRIS), is open to a wide range of stakeholders, including academic researchers, funders, industry players and regulators, and will bring together international experts to discuss the latest advancements in translational medicine.
The conference will focus on the latest approaches to increase chances of success in drug development, from novel in vitro systems to new biomarkers or clinical trial methodologies for patient selection and stratification.
Sept. 26, 2017
8:15 a.m. to 5 p.m. ET
National Institutes of Health
National Library of Medicine, Building 38A
Lister Hill National Center for Biomedical Communications
Lister Hill Center Auditorium
8600 Rockville Pike
Bethesda, Maryland 20894
The discovery of induced pluripotent stem cells (iPSCs) over a decade ago has transformed stem cell biology and biomedical research, ranging from disease modeling, drug discovery and predictive toxicology to regenerative medicine applications. To bring iPSC-based therapies more efficiently to patients, it is pivotal to continue addressing the key knowledge gaps and roadblocks in a coordinated multidisciplinary fashion. This workshop, hosted by NCATS, will focus on defining collaborative opportunities, addressing challenges and applying best practices in translational iPSC research. Topics of interest are quality control standards for pluripotency, safety, experimental reproducibility, cost-efficient scalability and manufacturing, improved and efficient differentiation protocols, advances in -omics and functional characterization of cell type identities, and other relevant questions. As a deliverable of the workshop, the gathered information and recommendations will be used to draft a white paper for the translational stem cell community.
Goals for the workshop include:
- Highlighting the biological and technological challenges of advancing iPSCs into clinical applications and drug discovery;
- Evaluating the state-of-the field of iPSC translation and discussing critical steps for quality control, standardization and reproducibility;
- Discussing methods of protocol development/optimization and molecular and functional analyses; and
- Seeking input from experts on areas of prioritization and tractable strategies for the iPSC field.
Oct. 23, 2017
8 a.m. to 6:30 p.m. ET
University of North Carolina at Chapel Hill
150 Stadium Drive
Chapel Hill, North Carolina 27514
NCATS is supporting this full-day workshop that will cover a broad range of critical concepts underlying assay development for high-throughput screening and lead discovery projects. This workshop, which will feature presentations by several NCATS staff members, is designed to disseminate critical information about the implementation of robust assay methods and is particularly relevant for researchers developing bioassays for the discovery of drugs or chemical probes. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery.
Along with the Assay Guidance Manual, this workshop will be a valuable resource for academic, industrial and government laboratory scientists who are developing test methods for low- or high-throughput screening that are amenable to automation using appropriate statistical and operational concepts. It will also be beneficial to early career researchers and experienced investigators who wish to learn about the latest assay concepts for high-throughput screening and lead optimization.
Registration is $185. Be sure to register no later than Oct. 13, 2017.