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Preclinical Research Toolbox

We collaborate with other NIH institutes and centers to develop tools and resources that accelerate preclinical research.

About Preclinical Research Toolbox

We have tools and resources to help scientists carry out preclinical research. Selected resources and software tools are listed below.

Small Molecules, Compounds and Probes

Assay Guidance Manual

This resource contains detailed information on developing appropriate assays for high-throughput screening projects.

Compound Management

Our compound management team uses sophisticated and automated techniques to supply chemicals for NCATS screening experiments to uncover new treatments for diseases.

NCATS Pharmaceutical Collection

This publicly available, web-based application provides complete information on active pharmaceutical ingredients.


PubChem is a freely accessible database of small organic molecules and their activities against biological assays.


We identify and optimize small molecule probes of novel, unexplored cellular targets. Probes are freely accessible to the scientific community.

Phenotypic Drug Discovery Resource

Supported through a collaboration with Eli Lilly and Company’s Open Innovation Drug Discovery program, this resource enables access to disease-relevant assays to explore the effects of small molecules on molecular processes.


BioPlanet is a publicly available, comprehensive database that details the body’s biological pathways. Researchers can use it to study gene activity, disease mechanisms, cell toxicity and more.


BEST (Biomarkers, EndpointS, and other Tools) Resource

This resource is an online glossary developed by a U.S. Food and Drug Administration and NIH joint committee to clarify terms used in translational science and medical product development, with a focus on study endpoints and biomarkers. 

Informatics Tools & Information Systems

Global Ingredient Archival System

The registration system for the ingredients in medicinal products makes it easier for stakeholders to exchange information about substances in medicines, supporting scientific research on the use and safety of these products.

Additional Software and Informatics Tools

These tools including specialized browsers, are available under “Software” in the right-hand column of the Tripod server.


We have filed patent applications on several technologies developed by center investigators. To ensure that these new technologies are further developed and commercialized, we seek collaboration and licensing partners.

Therapy Development

NCATS Toolkit for Patient-Focused Therapy Development

Toolkit is a centralized collection of online resources that can help patient groups progress through the research and development process for new treatments.

Last updated on April 20, 2024