Open Small Business Opportunities

• Grants
• Contracts
• NIH HEAL Initiative Funding Opportunities
• Notices Relevant to Small Businesses
• Need Help?

Grants

PHS 2020 Omnibus Solicitation of the NIH

• SBIR: PA-20-260 (R43/R44 - Clinical Trial Not Allowed)
• Posted: July 14, 2020
• Next Deadline: April 5, 2021

• STTR: PA-20-265 (R41/R42 - Clinical Trial Not Allowed)
• Posted: July 14, 2020
• Next Deadline: April 5, 2021

• Funding Information:
  • Research Topics
  • Approved Waiver Topics

NCATS will not accept SBIR/STTR applications that include clinical trials under the current Omnibus Solicitation. Learn more.

See About Small Business Opportunities for more information on the Phase IIB.

Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases

• SBIR: RFA-TR-21-010 (U44 - Clinical Trial Required)
• Posted: Jan. 13, 2021
• Next Deadline: April 13, 2021

Non-Viral Technologies for in vivo Delivery of Genome Editors

• SBIR: PAR-20-098 (R43/R44 - Clinical Trial Not Allowed)
• Posted: Feb. 6, 2020
• Next Deadline: April 5, 2021

• STTR: PAR-20-109 (R41/R42 - Clinical Trial Not Allowed)
• Posted: Feb. 6, 2020
• Next Deadline: April 5, 2021

Development of Highly Innovative Tools and Technology for Analysis of Single Cells

• SBIR: PA-20-047 (R43/R44 Clinical Trial Not Allowed)
• Posted: Jan. 8, 2020
• Next Deadline: April 5, 2021

• STTR: PA-20-025 (R41/R42 Clinical Trial Not Allowed)
• Posted: Jan. 7, 2020
• Next Deadline: April 5, 2021

Commercialization Readiness Pilot (CRP) Program Technical Assistance

• SBIR/STTR: PAR-20-128 (SB1, R44 - Clinical Trial Not Allowed)
• Posted: July 14, 2020
• Next Deadline: April 5, 2021

Innovation Corps (I-Corps™) at NIH Program for NIH and CDC Translational Research

• PA-19-029 (Admin Supp Clinical Trial Not Allowed)
• Posted: Oct. 17, 2018
• Next Deadline: Feb. 2, 2021

See: Additional Resources: 2020 SBIR/STTR Omnibus Solicitation Resources

Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project

• SBIR: PA-19-034 (R43/R44)
• Posted: Oct. 4, 2018
• Next Deadline: April 5, 2021

• STTR: PA-19-033 (R41/R42)
• Posted: Oct. 4, 2018
• Next Deadline: April 5, 2021

Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR 

• SBIR/STTR: PA-18-837
• Posted: June 20, 2018
• Notice: NOT-OD-19-016 
• Expiration date: Sept. 5, 2021

Contracts

FY 2021 NIH SBIR Contract Solicitation (PHS-2021-1)

• PHS-2021-1
• Posted: July 28, 2020
• Deadline: Oct. 26, 2020

HHS Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2020-1) Now Available

• NOT-OD-19-121

If you missed the August 11 webinar about the solicitation, check out the video recording on YouTube: HHS SBIR Contract RFP Informational Webinar PHS 2021-1.

NIH HEAL Initiative Funding Opportunities

America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis

• STTR: RFA-DA-19-020
• Posted: Dec. 10, 2018
• Next Deadline: April 9, 2021

• SBIR: RFA-DA-19-019
• Posted: Dec. 10, 2018
• Next Deadline: April 9, 2021

Notices Relevant to Small Businesses

Reminder of application instructions and policies impacting SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance PAR-19-333, PAR-19-334, and PAR-19-335

• NOT-OD-20-041

Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access

• NOT-DK-19-027

Notice of FY2020 Cohort Dates for PA-19-029, Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial Not Allowed)

• NOT-CA-19-067

Notice of Special Interest for Small Business Research for Methods Development in Natural Products Chemistry

• NOT-AT-19-025

Notice of Special Interest: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR) Standard

• NOT-OD-19-127

NIH Offers Assistance to Phase II HHS SBIR and STTR Awardees through the NIH Commercialization Accelerator Program (CAP) 2019-2020

• NOT-OD-19-129

NIH Offers Assistance to Active Phase I HHS SBIR and STTR Awardees through the Niche Assessment Program 2018-2019

• NOT-OD-19-012

Need Help?

The NCATS SBIR & STTR team is available to answer questions related to your potential project idea and provide tips for applying. If you have questions about a specific solicitation, connect with the program contact listed in the solicitation.

The Small Business Resources page offers tools and tips to help you develop a successful proposal and access other resources.