Open Small Business Opportunities


Grants

PHS 2020 Omnibus Solicitation of the NIH

  • SBIR: PA-20-260 (R43/R44 - Clinical Trial Not Allowed)
  • Posted: July 14, 2020
  • Next Deadline: Jan. 5, 2021
  • STTR: PA-20-265 (R41/R42 - Clinical Trial Not Allowed)
  • Posted: July 14, 2020
  • Next Deadline: Jan. 5, 2021

NCATS will not accept SBIR/STTR applications that include clinical trials under the current Omnibus Solicitation. Learn more.

See About Small Business Opportunities for more information on the Phase IIB.

Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases

  • SBIR: RFA-TR-20-032 (U44 Clinical Trial Required)
  • Posted: Sept. 15, 2020
  • Application Due Date: Nov. 12, 2020
  • Exploratory/Developmental Phased Award: RFA-TR-20-031 (UG3/UH3 Clinical Trial Required)
  • Posted: Sept. 15, 2020
  • Application Due Date: Nov. 12, 2020

Join our pre-application webinar for RFA-TR-20-031 and RFA-TR-20-032 on Thursday, Oct. 15, 2020.

Non-Viral Technologies for in vivo Delivery of Genome Editors

  • SBIR: PAR-20-098 (R43/R44 - Clinical Trial Not Allowed)
  • Posted: Feb. 6, 2020
  • Next Deadline: Jan. 5, 2021
  • STTR: PAR-20-109 (R41/R42 - Clinical Trial Not Allowed)
  • Posted: Feb. 6, 2020
  • Next Deadline: Jan. 5, 2021

Emergency Awards RADx-RAD: Novel Biosensing for Screening, Diagnosis and Monitoring of COVID-19 From Skin and The Oral Cavity

  • SBIR: RFA-OD-20-020  (R44 Clinical Trial Not Allowed) 
  • Posted: Aug. 6, 2020
  • Deadline: Sept. 18, 2020

Emergency Awards RADx-RAD: Novel Biosensing for Screening, Diagnosis and Monitoring of COVID-19 From Skin and The Oral Cavity

  • STTR: RFA-OD-20-021 (Fast-Track STTR Clinical Trial Not Allowed)
  • Post: Aug. 6, 2020
  • Deadline: Sept. 18, 2020

Development of Highly Innovative Tools and Technology for Analysis of Single Cells

  • SBIR: PA-20-047 (R43/R44 Clinical Trial Not Allowed)
  • Posted: Jan. 8, 2020
  • Next Deadline: Jan. 5, 2021
  • STTR: PA-20-025 (R41/R42 Clinical Trial Not Allowed)
  • Posted: Jan. 7, 2020
  • Next Deadline: Jan. 5, 2021

Commercialization Readiness Pilot (CRP) Program Technical Assistance

  • SBIR/STTR: PAR-20-128 (SB1, R44 - Clinical Trial Not Allowed)
  • Posted: July 14, 2020
  • Next Deadline: Jan. 5, 2021

Innovation Corps (I-Corps™) at NIH Program for NIH and CDC Translational Research

  • PA-19-029 (Admin Supp Clinical Trial Not Allowed)
  • Posted: Oct. 17, 2018
  • Next Deadline: Nov.17, 2020

See: Additional Resources: 2020 SBIR/STTR Omnibus Solicitation Resources

Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project

  • SBIR: PA-19-034 (R43/R44)
  • Posted: Oct. 4, 2018
  • Next Deadline: Jan. 5, 2021
  • STTR: PA-19-033 (R41/R42)
  • Posted: Oct. 4, 2018
  • Next Deadline: Jan. 5, 2021

Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR 

Contracts

FY 2021 NIH SBIR Contract Solicitation (PHS-2021-1)

  • PHS-2021-1
  • Posted: July 28, 2020
  • Deadline: Oct. 26, 2020

HHS Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2020-1) Now Available

If you missed the August 11 webinar about the solicitation, check out the video recording on YouTube: HHS SBIR Contract RFP Informational Webinar PHS 2021-1.

NIH HEAL Initiative Funding Opportunities

America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis

  • STTR: RFA-DA-19-020
  • Posted: Dec. 10, 2018
  • Next Deadline: April 9, 2021
  • SBIR: RFA-DA-19-019
  • Posted: Dec. 10, 2018
  • Next Deadline: April 9, 2021

Notices Relevant to Small Businesses

Reminder of application instructions and policies impacting SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance PAR-19-333, PAR-19-334, and PAR-19-335

Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access

Notice of FY2020 Cohort Dates for PA-19-029, Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial Not Allowed)

Notice of Special Interest for Small Business Research for Methods Development in Natural Products Chemistry

Notice of Special Interest: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR) Standard

NIH Offers Assistance to Phase II HHS SBIR and STTR Awardees through the NIH Commercialization Accelerator Program (CAP) 2019-2020

NIH Offers Assistance to Active Phase I HHS SBIR and STTR Awardees through the Niche Assessment Program 2018-2019

Need Help?

The NCATS SBIR & STTR team is available to answer questions related to your potential project idea and provide tips for applying. If you have questions about a specific solicitation, connect with the program contact listed in the solicitation.

The Small Business Resources page offers tools and tips to help you develop a successful proposal and access other resources.