Open Small Business Funding Opportunities

• Grants
• Contracts
• NIH HEAL Initiative Funding Opportunities
• Notices Relevant to Small Businesses
• Need Help?

Grants

PHS 2020 Omnibus Solicitation of the NIH

• SBIR: PA-21-259 (R43/R44 - Clinical Trial Not Allowed)
• Posted: July 8, 2021
• Next Deadline: Sept. 7, 2021

• STTR: PA-21-262 (R41/R42 - Clinical Trial Not Allowed)
• Posted: July 8, 2021
• Next Deadline: Sept. 7, 2021

• Funding Information:
  • Research Topics
  • Approved Waiver Topics

NCATS will not accept SBIR/STTR applications that include clinical trials under the current Omnibus Solicitation. Learn more.

See About Small Business Opportunities for more information on the Phase IIB.

Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health

• NOT-EB-21-001
• Posted: Feb. 22, 2021
• Next Deadline: Sept. 7, 2021

Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases

• SBIR: RFA-TR-21-010 (U44 - Clinical Trial Required)
  • NOT-TR-21-023: Notice of Correction to Application Types Allowed for RFA-TR-21-010 Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)
• Posted: Jan. 13, 2021
• Next Deadline: Sept. 13, 2021

Non-Viral Technologies for in vivo Delivery of Genome Editors

• SBIR: PAR-20-098 (R43/R44 - Clinical Trial Not Allowed)
• Posted: Feb. 6, 2020
• Next Deadline: Sept. 7, 2021

• STTR: PAR-20-109 (R41/R42 - Clinical Trial Not Allowed)
• Posted: Feb. 6, 2020
• Next Deadline: Sept. 7, 2021

Development of Highly Innovative Tools and Technology for Analysis of Single Cells

• SBIR: PA-20-047 (R43/R44 Clinical Trial Not Allowed)
• Posted: Jan. 8, 2020
• Next Deadline: Sept. 7, 2021

• STTR: PA-20-025 (R41/R42 Clinical Trial Not Allowed)
• Posted: Jan. 7, 2020
• Next Deadline: Sept. 7, 2021

Commercialization Readiness Pilot (CRP) Program Technical Assistance

• SBIR/STTR: PAR-20-128 (SB1, R44 - Clinical Trial Not Allowed)
• Posted: July 14, 2020
• Next Deadline: Sept. 7, 2021

See: Additional Resources: 2020 SBIR/STTR Omnibus Solicitation Resources

Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project

• SBIR: PA-19-034 (R43/R44)
• Posted: Oct. 4, 2018
• Next Deadline: Sept. 7, 2021

• STTR: PA-19-033 (R41/R42)
• Posted: Oct. 4, 2018
• Next Deadline: Sept. 7, 2021

Administrative Supplements to Promote Diversity in Research and Development Small Businesses-SBIR/STTR 

• SBIR/STTR: PA-18-837
• Posted: June 20, 2018
• Notice: NOT-OD-19-016 
• Expiration date: Sept. 7, 2021

Contracts

Topic 022 - Technological Development and Validation of Remote Measures for Use in Clinical Trials in Individuals with Rare Diseases

• Due Date: Oct. 28, 2021

NIH HEAL Initiative Funding Opportunities

America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis

• STTR: RFA-DA-19-020
• Posted: Dec. 10, 2018
• Next Deadline: Sept. 8, 2021

• SBIR: RFA-DA-19-019
• Posted: Dec. 10, 2018
• Next Deadline: Sept. 8, 2021

Notices Relevant to Small Businesses

Notice of Special Interest (NOSI): Administrative Supplement for Providing Technical and Business Assistance (TABA) Funding to SBIR/STTR Awardees (Admin Supp)

• NOT-OD-21-062

Technical and Business Assistance (TABA) Needs Assessment Program for NIH SBIR/STTR Awardees (not applicable to grantees who applied for NOT-OD-21-062)

• SBIR/STTR: NOT-OD-21-023

Notice of Correction to Application Types Allowed for RFA-TR-21-010 Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases

• NOT-TR-21-023

Reminder of application instructions and policies impacting SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance PAR-19-333, PAR-19-334, and PAR-19-335

• NOT-OD-20-041

Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access

• NOT-DK-19-027

NIH Offers Assistance to Active Phase I HHS SBIR and STTR Awardees through the Niche Assessment Program 2018-2019

• NOT-OD-19-012

Need Help?

The NCATS SBIR & STTR team is available to answer questions related to your potential project idea and provide tips for applying. If you have questions about a specific solicitation, connect with the program contact listed in the solicitation.

The Small Business Resources page offers tools and tips to help you develop a successful proposal and access other resources.