Open Small Business Funding Opportunities


PHS Omnibus Solicitation of the NIH

NCATS will not accept SBIR/STTR applications that include clinical trials under the current Omnibus Solicitation. Learn more.

Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

  • SBIR: RFA-TR-22-029
  • Post: July 13, 2021
  • Next Deadline: Nov. 18, 2022

NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

  • SBIR: RFA-HL-23-008
  • Post: Nov. 16, 2021
  • Next Deadline: Feb. 28, 2023

See About Small Business Opportunities for more information on the Phase IIB.

Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)

  • PAR-22-073
  • Post: Nov. 19, 2021
  • Next Deadline: Nov.15, 2022

Development of Highly Innovative Tools and Technology for Analysis of Single Cells

  • SBIR: PA-20-047 (R43/R44 Clinical Trial Not Allowed)
  • Posted: Jan. 8, 2020
  • Next Deadline: Sept. 6, 2022
  • STTR: PA-20-025 (R41/R42 Clinical Trial Not Allowed)
  • Posted: Jan. 7, 2020
  • Next Deadline: Sept. 6, 2022

Commercialization Readiness Pilot (CRP) Program Technical Assistance

  • SBIR/STTR: PAR-20-128 (SB1, R44 - Clinical Trial Not Allowed)
  • Posted: July 14, 2020
  • Next Deadline: Sept. 6, 2022

See: Additional Resources: 2020 SBIR/STTR Omnibus Solicitation Resources

Administrative Supplements to Promote Diversity in Research and Development Small Businesses-SBIR/STTR 

  • PA-21-345: Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
  • Posted: Sept. 10, 2021
  • Expires: Sept. 10, 2024


A Solicitation of the National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC) for Small Business Innovation Research (SBIR) Contract Proposals

  • SBIR: PHS-2023-1
  • Post: July 20, 2022
  • Closing Date: Nov. 4, 2022

Notices Relevant to Small Businesses

Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health (Clinical Trial Optional)

Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health

  • NOT-EB-21-001
  • Posted: Feb. 22, 2021
  • Next Deadline: Sept. 6, 2022

Notice of Special Interest (NOSI): Administrative Supplement for Providing Technical and Business Assistance (TABA) Funding to SBIR/STTR Awardees (Admin Supp)

Technical and Business Assistance (TABA) Needs Assessment Program for NIH SBIR/STTR Awardees (not applicable to grantees who applied for NOT-OD-21-062)

Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access

NIH Offers Assistance to Active Phase I HHS SBIR and STTR Awardees through the Niche Assessment Program 2018-2019

Need Help?

The NCATS SBIR & STTR team is available to answer questions related to your potential project idea and provide tips for applying. If you have questions about a specific solicitation, connect with the program contact listed in the solicitation.

The Small Business Resources page offers tools and tips to help you develop a successful proposal and access other resources.