Open Small Business Opportunities

• Grants
• NIH HEAL Initiative^SM Funding Opportunities
• Contracts
• Notices Relevant to Small Businesses
• Need Help?

Grants

Commercialization Readiness Pilot (CRP) Program Technical Assistance

• SBIR/STTR: PAR-19-334 (SB1, R44 - Clinical Trial Not Allowed)
• Posted: Aug. 5, 2019
• Next deadline: Sept. 5, 2019

Methods to Improve Reproducibility of Human iPSC Derivation, Growth and Differentiation

• SBIR: RFA-GM-19-001 (R44 - Clinical Trial Not Allowed)
• Posted: May 21, 2019
• Next deadline: Jan. 6, 2020

PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications

• STTR: PA-19-270 (R41/R42 - Clinical Trial Not Allowed)
• Posted: May 7, 2019
• Next deadline: Sept. 5, 2019

• STTR: PA-19-271 (R41/R42 - Clinical Trial Required)
• Posted: May 7, 2019
• Next deadline: Sept. 5, 2019

• NOT-AT-19-025: Notice of Special Interest for Small Business Research for Methods Development in Natural Products Chemistry
• Posted: Aug. 6, 2019
   
• SBIR/STTR: NOT-OD-19-127 Notice of Special Interest: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR) Standard
• Posted: July 30, 2019

See: Additional Resources: 2019 SBIR/STTR Omnibus Solicitation Resources

PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications

• SBIR: PA-19-272 (R43/R44 - Clinical Trial Not Allowed)
• Posted: May 7, 2019
• Next deadline: Sept. 5, 2019

• SBIR: PA-19-273 (R43/R44 - Clinical Trial Required)
• Posted: May 7, 2019
• Next deadline: Sept. 5, 2019

• NOT-AT-19-025: Notice of Special Interest for Small Business Research for Methods Development in Natural Products Chemistry
• Posted: Aug. 6, 2019
   
• SBIR/STTR: NOT-OD-19-127 Notice of Special Interest: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR) Standard
• Posted: July 30, 2019

See: Additional Resources: 2019 SBIR/STTR Omnibus Solicitation Resources

Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project

• SBIR: PA-19-034 (R43/R44)
• Posted: Oct. 4, 2018
• Next deadline: Sept. 5, 2019

• STTR: PA-19-033 (R41/R42)
• Posted: Oct. 4, 2018
• Next deadline: Sept. 5, 2019

Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR 

• SBIR/STTR: PA-18-837
• Posted: June 20, 2018
• Notice: NOT-OD-19-016 
• Expiration date: Sept. 5, 2021

Development of Highly Innovative Tools and Technology for Analysis of Single Cells

• SBIR: PA-17-147 (R43/R44)
• Posted: Feb. 1, 2017
• Next deadline: Sept. 5, 2019

• STTR: PA-17-148 (R41/R42)
• Posted: Feb. 1, 2017
• Next deadline: Sept. 5, 2019

Platform Delivery Technologies for Nucleic Acid Therapeutics

• SBIR: PAR-17-035
• Posted: Oct. 27, 2016
• Notice: NOT-TR-19-004
• Notice: NOT-TR-17-020
• Final deadline: Sept. 5, 2019

• STTR: PAR-17-036
• Posted: Oct. 27, 2016
• Notice: NOT-TR-17-021
• Final deadline: Sept. 5, 2019

NIH HEAL Initiative^SM Funding Opportunities

America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis

• SBIR: RFA-DA-19-019
• Posted: Dec. 10, 2018
• Next deadline: Sept. 8, 2019

• STTR: RFA-DA-19-020
• Posted: Dec. 10, 2018
• Next deadline: Sept. 8, 2019

Contracts

HHS Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2020-1) Now Available

• NOT-OD-19-121

Notices Relevant to Small Businesses

NIH Offers Assistance to Phase II HHS SBIR and STTR Awardees through the NIH Commercialization Accelerator Program (CAP) 2019-2020

• NOT-OD-19-129

NIH Offers Assistance to Active Phase I HHS SBIR and STTR Awardees through the Niche Assessment Program 2018-2019

• NOT-OD-19-012

Notice of NIA Participation in RFA-HL-18-023 "Stimulating Access to Research in Residency (StARR) (R38)"

• NOT-AG-18-009

Notice of Corrected Expiration Date for PA-15-354 "SBIR Technology Transfer (R43/R44)"

• NOT-NS-18-031

NIH Offers Assistance to Active Phase I HHS SBIR and STTR Awardees through the Niche Assessment Program 2017-2018

• NOT-OD-17-128

NIH Implementation of Final Research Performance Progress Reports for SBIR and STTR Grants and Cooperative Agreements

• NOT-OD-17-085

Update on Clinical Trial Funding Opportunity Announcement Policy

• NOT-OD-17-043

ASSIST Now an Option for Small Business Grant Applications

• NOT-OD-15-156

Applicant Responsibilities in Maintaining the Integrity of NIH Peer Review

• NOT-OD-15-106

HHS Changes Standard Due Dates for SBIR/STTR Grant Applications

• NOT-OD-15-038

NIH Implements Option for Applicants to Switch between the SBIR/STTR Programs and the SBIR Direct to Phase II Pilot of the SBIR/STTR Reauthorization Act of 2011

• NOT-OD-14-048

Need Help?

The NCATS SBIR & STTR team is available to answer questions related to your potential project idea and provide tips for applying. If you have questions about a specific solicitation, connect with the program contact listed in the solicitation.

The Small Business Resources page offers tools and tips to help you develop a successful proposal and access other resources.