Stimulating Peripheral Activity to Relieve Conditions (SPARC) is an NIH Common Fund program that focuses on understanding peripheral nerves — nerves that connect the brain and spinal cord to the rest of the body — and how their electrical signals control internal organ function. Modulation of these control signals is a potentially powerful way to treat common conditions and diseases such as rheumatoid arthritis and heart failure. Methods and medical devices that modulate peripheral nerve activity are becoming available, but more research is needed to fully understand how these therapies act on a target organ’s cells. Such understanding could help both explain why a particular therapy may be effective in one individual but not in another as well as resolve the issue, thereby making these therapies more effective.
SPARC Program Goals
The 2016 SPARC-funded investigators are working collectively as a consortium to address the program’s aims and goals via:
- Biological projects to develop detailed anatomical and functional maps that illustrate how peripheral nerves control organ function;
- Technology development projects to create or improve tools to measure and manipulate nerve-organ interactions and isolate their functions;
- Collaborations between private-sector scientists and academic researchers, to expedite the development of new therapeutic strategies;
- Expertise leveraged from many different sources, including academic laboratories, independent inventors, start-ups, small and large businesses, and international organizations; and
- SPARC program-developed data and tools shared through a central online resource.
To achieve these goals, NIH envisions a consortium tasked with managing these four components:
- Anatomical and Functional Mapping of the Innervation of Major Organs (RFA-RM-15-003, RFA-RM-15-018, RFA-RM-15-019 and RFA-RM-15-020);
- Next-Generation Tools and Technologies (RFA-RM-16-002 and RFA-RM-16-003);
- Use of Existing Market-Approved Technology for New Market Indications (RFA-RM-16-027 and RFA-RM-16-009); and
- SPARC Data Coordination (NOT-RM-16-032).
A Trans-NIH Initiative
SPARC is funded through the NIH Common Fund and managed by the NIH Office of the Director in partnership with NCATS, the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute of Neurological Disorders and Stroke.
NCATS’ role in this effort is to provide program management and administrative support, along with expertise in enabling industry collaborations. NCATS helps the NIH Common Fund administer the awards for SPARC projects that use the Other Transaction funding mechanism. NCATS also provides programmatic management for awards from RFA-RM-16-009.
Template agreements with several device manufacturers have made those companies’ neuromodulation technology (i.e., implantable devices with recording and/or stimulation capabilities) available to SPARC investigators. The aim is to promote pre-clinical development of these technologies, in support of a new use, toward enabling an Investigational Device Exemption submission to the Food and Drug Administration for a future pilot clinical study. These pilot clinical studies are designed to provide the initial proof-of-concept demonstrations in humans to spur the additional studies needed for pursuit of FDA approval as a labeled indication.
NCATS-Administered SPARC Projects
Brendan J. Canning, Ph.D. (contact), Marian Kollarik, M.D., Ph.D., and Wayne Mitzner, Ph.D., Johns Hopkins University
Jiande Chen, Ph.D., Johns Hopkins University
Jieyun Yin, M.D., Transtimulation Research, Inc.
This funding opportunity was reissued on Oct. 19, 2016, as RFA-RM-16-027. Applications are due Dec. 21, 2016.