Staff Profile: Brittany M. Haynes

Brittany M. Haynes, Ph.D.

Scientific Program Specialist

Office of Policy, Communications and Education
Education Branch

National Center for Advancing Translational Sciences

National Institutes of Health

Email Brittany M. Haynes

Biography

Brittany Haynes is a scientific program specialist in the Education Branch of NCATS’ Office of Policy, Communications and Education, where she works to evaluate translational science training programs and develop translational science curriculums.

Previously, Haynes was an AAAS Science and Technology Policy Fellow in the Division of Preclinical Innovation training office, where she ensured that trainees received the best possible translational science training experience by developing operational policies and professional and scientific development programming.

Prior to joining NCATS, Haynes was a postdoctoral fellow at the National Cancer Institute, where she conducted research on the mechanisms of olaparib and prexasertib resistance in high-grade serous ovarian cancers, with a concentration on replication fork stabilization.

Haynes received her doctorate in cancer biology from Wayne State University (WSU). Her dissertation project focused on the role of the DNA damage response in drug resistance. Specifically, she investigated the role of the Rad6-translesion synthesis pathway and characterized a RAD6-specific small molecular inhibitor in triple-negative breast cancer cell lines. Outside of the laboratory, Haynes was elected to serve as a student representative for her graduate program and acted as a recruiter for her graduate program at national conferences. She also was selected to serve as a student representative to the WSU Graduate Council, where she advocated for policies to improve the diversity of admissions to Ph.D. programs. Haynes has extensive experience mentoring students—from elementary school through undergraduate programs—through the Initiative for Maximizing Student Diversity at WSU, Big Brothers Big Sisters of Metropolitan Detroit, and Big Brothers Big Sisters, National Capital Area.

Professional Interests

Haynes is interested in expanding the translational science workforce and is actively engaged in recruitment efforts at the intern, post-baccalaureate, graduate and postdoctoral levels.

Selected Publications

  1. RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
  2. Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition.
  3. Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization.
  4. Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance.