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Staff Profile: Ruili Huang

Ruili Huang, Ph.D.

Senior Scientist, Leader, Informatics, Toxicology in the 21st Century

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

E-mail Ruili Huang

Biography

Ruili Huang is the lead informatics scientist on the toxicity profiling team at NCATS and the co-chair of the bioinformatics working group of the Toxicology in the 21st Century (Tox21) initiative. Huang came to NCATS in 2006 from the National Cancer Institute, where she was a computational biologist on a Cancer Research Training Award working on deconvoluting biochemical pathways and drug-gene-pathway relationships. She received her Ph.D. in chemistry from Iowa State University, working on chemical kinetics and mechanisms for reactions catalyzed by organometallic compounds.

Research Topics

In her current position, Huang contributes to quantitative high-throughput screening data processing and interpretation and to development and implementation of software tools and algorithms that facilitate NCATS’ data pipeline. For Tox21, she evaluates assay performance for prioritization and analyzes compound toxicity profiling data to generate hypotheses on compound mechanisms of toxicity and to build predictive models for in vivo toxicity. In addition, she integrates biological pathway information and assay data that allow Tox21 researchers to systematically analyze and model toxicity responses and to design assays that can measure the chemical responses of these pathways.

Selected Publications

  1. Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.
  2. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.
  3. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
  4. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
  5. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.