Ruili Huang is the lead informatics scientist on the toxicity profiling team at NCATS and the co-chair of the bioinformatics working group of the Toxicology in the 21st Century (Tox21) initiative. Huang came to NCATS in 2006 from the National Cancer Institute, where she was a computational biologist on a Cancer Research Training Award working on deconvoluting biochemical pathways and drug-gene-pathway relationships. She received her Ph.D. in chemistry from Iowa State University, working on chemical kinetics and mechanisms for reactions catalyzed by organometallic compounds.
In her current position, Huang contributes to quantitative high-throughput screening data processing and interpretation and to development and implementation of software tools and algorithms that facilitate NCATS’ data pipeline. For Tox21, she evaluates assay performance for prioritization and analyzes compound toxicity profiling data to generate hypotheses on compound mechanisms of toxicity and to build predictive models for in vivo toxicity. In addition, she integrates biological pathway information and assay data that allow Tox21 researchers to systematically analyze and model toxicity responses and to design assays that can measure the chemical responses of these pathways.