Staff Profile: Richa M. Lomash

Richa M. Lomash
Richa M. Lomash, Ph.D.

Scientific Project Manager

Division of Preclinical Innovation
Therapeutic Development Branch (Contractor)

National Center for Advancing Translational Sciences

National Institutes of Health

Email Richa M. Lomash


Richa Lomash is a scientific project manager in the Therapeutic Development Branch within NCATS’ Division of Preclinical Innovation. In this capacity, she manages multiple projects in the Therapeutics for Rare and Neglected Diseases (TRND) portfolio. Her duties involve reviewing scientific merit, gap analysis, project kick-off, research plan development, project execution, contracting research studies and project closeout. She also provides scientific and management support to the program’s translational science initiatives.

Richa is trained as a cell biologist, working primarily in the field of cellular machinery and intracellular transport mechanisms. Prior to joining NCATS, Richa was an intramural research fellow at the National Institute of Neurological Disorders and Stroke. She discovered and characterized a novel GTPase in the mammalian brain, called neurolastin, and correlated its function to stress-induced morphological alterations in mitochondria and the function of excitatory synapses. Her work also shed more light on the role of auxiliary subunits in the transport of glutamate receptors to synapses during neurotransmission.

Richa received her doctorate in cell biology from the National Institute of Immunology in India, studying the overarching theme of intracellular transport. She delineated different mechanisms devised by intracellular pathogens for hijacking the host cellular transport machinery to establish infection within the immune cells.

Research Topics

Richa has a keen interest in advancing translational science, with the aim of benefitting human health. Within the TRND portfolio, Richa’s research projects span an array of therapeutic modalities, including small molecules, peptides and gene therapy, that are being applied to areas ranging from infectious diseases to metabolic, neurological and musculoskeletal disorders. Additionally, she collaborates with different partners to support NCATS’ mission to develop resources and research platforms that benefit future gene therapy clinical trials for extremely rare diseases. She also continually explores new technologies and approaches for streamlining management strategies and operational processes within the program.

Selected Publications

  1. Neurolastin, a Dynamin Family GTPase, Translocates to Mitochondria upon Neuronal Stress and Alters Mitochondrial Morphology In Vivo
  2. Salmonella SipA Mimics a Cognate SNARE for Host Syntaxin8 to Promote Fusion with Early Endosomes
  3. Phosphorylation of the Kainate Receptor (KAR) Auxiliary Subunit Neto2 at Serine 409 Regulates Synaptic Targeting of the KAR Subunit GluK1
  4. Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density
  5. Salmonella Acquires Lysosome-associated Membrane Protein 1 (LAMP1) on Phagosomes from Golgi via SipC Protein-mediated Recruitment of Host Syntaxin6