Staff Profile: Natalia Martinez

Natalia J. Martinez, Ph.D.
Natalia J. Martinez, Ph.D.

Research Scientist (Biology), Early Translation Branch (Contractor)

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

Email Natalia J. Martinez

Biography

Natalia J. Martinez joined NCATS in the summer of 2013 as a biology research scientist in the Division of Pre-Clinical Innovation, where she collaborates on projects with academia and the private sector throughout the translational science landscape. As part of an interdisciplinary group of scientists and engineers, she works toward the design, miniaturization, optimization and implementation of cell-based and biochemical assays for high-throughput screening and profiling of small molecules.

Before joining NCATS, Martinez was a postdoctoral fellow in the laboratory of Richard I. Gregory, Ph.D., at the Harvard Medical School-affiliated Boston Children’s Hospital. She joined Dr. Gregory’s lab and The Stem Cell Program to study how small regulatory RNAs are generated, how they exert their gene regulatory function and their role in the self-renewal and pluripotency of embryonic stem cells.

Martinez earned her doctorate in biomedical sciences from the University of Massachusetts Medical School, where she was mentored by A. J. Marian Walhout, Ph.D., in the Program of Gene Function and Expression. She contributed to the development and implementation of high-throughput yeast-one hybrid assays to map, characterize and validate genome-scale microRNA regulatory networks.

Martinez received her bachelor’s degree in biotechnology from the Universidad Nacional de Quilmes in Buenos Aires, Argentina, where she worked in the area of biotransformations using Escherichia coli as a microbial catalyst to synthesize modified nucleosides for antiviral therapy applications. She also gained experience in cancer research while working as a research assistant in the laboratory of Lucio H. Castilla, Ph.D., at the University of Massachusetts, investigating the genetics of acute myeloid leukemia in mouse models.

Research Topics

Martinez’s research focuses on developing and implementing physiologically relevant assay platforms applicable to diverse disease pathologies and conditions, with the ultimate goal of identifying probes with therapeutic potential. Her research interests also include novel high-throughput screening paradigms and technology development for the characterization of small molecules. She currently is engaged in collaborative projects related to cancer, cancer stem cells and metabolism, epigenetics, polycystic kidney disease, and neurodegenerative disorders.

Selected Publications

  1. A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.
  2. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
  3. Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
  4. A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
  5. A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.