HHS Logo U.S. Department of Health & Human Services Divider arrow NIH logo National Institutes of Health Alt desc
Skip Over Navigation Links
Staff banner

Staff Profile: Ilyas Singeç

Ilyas Singeç, M.D., Ph.D.

Head, Stem Cell Research

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

E-mail Ilyas Singeç

Biography

Ilyas Singeç joined NCATS in 2015 as the director of Stem Cell Translation Laboratory in the Division of Pre-Clinical Innovation. Singeç translates stem cell discoveries into clinical applications, focusing on the development of new assays (tests), drugs and cell therapies.

Prior to joining NCATS, Singeç carried out postdoctoral work first at the National Institute of Neurological Disorders and Stroke and then at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, where he also served as staff scientist and director of cell reprogramming. Most recently, Singeç worked in the pharmaceutical and entrepreneurial industries.

Singeç earned his M.D. and Ph.D. summa cum laude in Germany at the Universities of Bonn and Freiburg, completing his residency in clinical neuropathology and neuroanatomy in Freiburg.

Research Topics

Using human induced pluripotent stem cells as a model system, Singeç is interested in industrial-scale cellular engineering for regenerative medicine, characterization of cell type identities and developmental states using integrated orthogonal methods and quantitative systems biology, and genetics-based disease modeling of neurological and psychiatric disorders.

Selected Publications

  1. Translating Stem Cell Biology Into Drug Discovery.
  2. The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model.
  3. Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years.
  4. The leading edge of stem cell therapeutics.
  5. Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology.