Staff Profile: Carlos A. Tristan

Carlos A. Tristan, Ph.D.

Scientist, Stem Cell Translation Laboratory (Contractor)

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

Email Carlos A. Tristan

Biography

Carlos Tristan joined NCATS as a scientist in the Stem Cell Translation Laboratory within the Division of Pre-Clinical Innovation at NCATS. Tristan works on developing and optimizing cell culture protocols and cell-based assays for the maintenance and differentiation of induced pluripotent stem cells (iPSCs). 

Prior to joining NCATS, Tristan conducted his postdoctoral work at the Radiation Oncology Branch of the National Cancer Institute’s Center for Cancer Research in Bethesda, Maryland, where he focused on understanding the molecular mechanisms of glioblastoma multiforme.

Tristan earned his Ph.D. in cellular and molecular medicine from the Johns Hopkins University School of Medicine, where he worked in the Department of Psychiatry and Behavioral Sciences under Akira Sawa, M.D., Ph.D., to uncover novel signaling mechanisms and crosstalk among cell stress-signaling cascades. Tristan earned an M.S. in biology and two bachelor’s degrees in chemistry and biology from California State University in Fresno, California.

Research Topics

Tristan is interested in developing robust and scalable protocols for the maintenance and differentiation of iPSCs for high-throughput screening assays and clinical applications.

Selected Publications

  1. Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma.
  2. Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade.
  3. The diverse functions of GAPDH: views from different subcellular compartments.
  4. Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody.