TRND program supports preclinical development of therapeutic candidates intended to treat rare or neglected disorders, with the goal of enabling an Investigational New Drug (IND) application. Learn more.
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Research
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Therapeutics for Rare and Neglected Diseases (TRND)
NCATS Preclinical Therapeutic Development Programs Now Accepting Proposals to Collaborate
The NCATS Therapeutic Development Branch is accepting proposals to collaborate with the TRND and Bridging Interventional Development Gaps programs. Proposals are due Sept. 30, 2023.
About TRNDTRND supports preclinical development from lead optimization through IND application.
Scientific CapabilitiesTRND offers world-class in-house experts and connections to external resources.
Work with TRNDPartner with TRND to create and implement a therapeutic project plan for in-kind resources.
TRND ProjectsExplore active and completed therapeutic development projects supported by TRND, including projects with clinical activities.
TRND supports preclinical development from lead optimization through IND application.
TRND offers world-class in-house experts and connections to external resources.
Partner with TRND to create and implement a therapeutic project plan for in-kind resources.
Explore active and completed therapeutic development projects supported by TRND, including projects with clinical activities.
Work with Us
TRND stimulates therapeutic development research collaborations among NIH and academic scientists, nonprofit organizations, and pharmaceutical and biotechnology companies working on rare and neglected illnesses. Learn more and contact TRND.
Why TRND Matters
There are more than 6,500 identified rare and neglected diseases, yet only about 250 treatments are available for these conditions. One reason is that limited numbers of patients can make gathering information and designing drug studies difficult. As a result, scientists often know little about the symptoms and biology of these conditions. Another obstacle is that some private companies may find it difficult to justify the cost of developing drugs for such small rare disease markets. Even in the case of infectious diseases — such as malaria — that inflict health burdens on large numbers of people in the developing world, the private sector often neglects therapeutic development because of insufficient economic incentives. Learn more about TRND.
TRND Facts
Download the TRND fact sheet (PDF - 347KB).
NCATS Programs & Initiatives
- Funding & Notices
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