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Careers at NCATS

We are looking for innovative partners to join our dynamic team. Learn more about current job opportunities at NCATS.

Job Opportunities

Information provided by candidates will remain confidential and will not be released outside NCATS' search process without signed consent from candidates.

Postdoctoral Positions in the Division of Preclinical Innovation

NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. NIH and HHS are Equal Opportunity Employers.

NIH is dedicated to building a diverse community in its training and employment programs.

Federal Background Check

Selected candidates for any fellowship opportunity described above are subject to a federal background check, using Standard Form-85 (read SF-85). Section 14 of the form asks, "In the last year, have you used, possessed, supplied, or manufactured illegal drugs?" The question refers to the illegal use of drugs or controlled substances in accordance with federal laws, even though allowed under state laws. Acceptance into all fellowship programs is conditional upon a successful background check.

Learn more about jobs at NIH


Ethics Specialist, Ethics and Management Analysis Branch, Office of Administrative Management

National Institutes of Health
National Center for Advancing Translational Sciences
Office of Administrative Management
Ethics and Management Analysis Branch
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates for an ethics specialist position in the Ethics and Management Analysis Branch within the Office of Administrative Management. NCATS uses its Translational Science Principles to conduct research and support activities that address challenges along the translational research pipeline so that new health solutions reach people faster.

Core Responsibilities

The chosen candidate will work with NCATS’ ethics coordinator to (1) carry out the activities of the NCATS and NIH Ethics Offices; (2) help support the center’s Ethics Program; (3) plan, administer and implement the Ethics Program; and (4) ensure that the program is carried out in line with ethics regulations and statutes. Specific duties include, but are not limited to, advising center staff on interpreting and applying ethics statutes, regulations and policies on a wide range of ethics topics; managing aspects of the public and confidential financial disclosure program; and performing ethics analyses.

Qualifications

To qualify for an Ethics Program Specialist GS-0301 position at the GS-11 level, you must have:
(A) Completed a Ph.D. or equivalent doctoral degree, or 3 full years of progressively higher level graduate education leading to such a degree or an LL.M. Education must be related to the position; OR
(B) One year of specialized experience equivalent to at least the GS-09 level in the federal service obtained in either the private or public sector performing the following types of tasks: (1) providing advice to employees on applying ethics statutes, regulations and policies; (2) monitoring the financial disclosure process, notifying employees and reviewing financial disclosure forms; and (3) presenting reports on ethics considerations to management officials; OR
(C) A combination of postbaccalaureate education related to the position and experience that meets all the qualification requirements for this position.

To qualify for an Ethics Program Specialist GS-0301 position at the GS-12 level, you must have:
(A) One year of specialized experience equivalent to at least the GS-11 level in the federal service obtained in either the private or public sector performing the following types of tasks: (1) providing advice to employees and managers on interpreting and applying ethics statutes, regulations and policies on such issues as financial disclosure, recusals and gift exceptions; (2) reviewing confidential and public financial disclosure reports or prohibited holdings reports; (3) providing advice on possible conflicts of interest and recommending corrective actions; and (4) designing ethics training courses and materials; OR
(B) A combination of education and specialized experience that meets all the qualification requirements for this position.

Salary/Benefits

Salary is commensurate with qualifications and experience and NIH salary guidelines. A full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Interested individuals should apply from February 26 to March 1, 2024, via USAJobs.gov Ethics Specialist announcement number NIH-NCATS-IMP-24-12268491. This announcement will close at 11:59 p.m. EST on March 1, 2024, or at 11:59 p.m. EST on the day that the 75th application is received, whichever comes first. The announcement is for Montgomery County, Maryland, and all U.S. locations; it includes additional information regarding qualification requirements, evaluation criteria and application instructions.

Please direct questions about applying to Ryan Gale at ryan.gale@nih.gov.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Staff Scientist (Data Scientist), Division of Preclinical Innovation, Chemistry Technologies Development Laboratory

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemistry Technologies Development Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a staff scientist (data scientist) position in the Chemistry Technologies Development (CTD) laboratory (administered by the Chemistry Technology program) within the center’s Division of Preclinical Innovation (DPI). The mission of the CTD laboratory is to conduct chemistry and biological research on various diseases and find opportunities at the interfaces of chemistry, biology and medicine. The CTD employs state-of-the-art methods in disease model development and characterization, high-throughput chemogenomics screening, medicinal chemistry/chemical biology, and therapeutic development to pursue a wide range of research goals in collaboration with other NIH intramural scientists, academic colleagues and industry partners.

The CTD laboratory pursues five core domains of research: (1) biologically active small molecule discovery, (2) disease model design/characterization, (3) mechanistically focused drug positioning, (4) innovations in bioinformatics, and (5) advancing concepts in precision medicine. The longer-term vision includes two independent precision medicine teams focused on several cancer subtypes in collaboration with the National Cancer Institute.

Core Responsibilities

The successful candidate will develop novel informatics and statistical methods/workflows and proof-of-concept tools to support the integration, analysis and interpretation of translational research data and make these outcomes publicly available to the broader research community. These data result from efforts in basic research, patient-oriented research and population-based research. The selected candidate will interact closely with the CTD laboratory director, computational and noncomputational (e.g., biologists, chemists, clinicians) CTD and NCATS scientists, and our academic collaborators. He or she will contribute to the strategic vision and to the mentoring of trainees. The selected candidate will be encouraged to seek out collaborations within NCATS and NIH or externally to further amplify and improve the center’s CTD informatics methods and software. He or she will elaborate on machine and deep learning and architectures from the aggregation and cleaning of in-house translational research data (e.g., high-throughput screens, multi-omic knowledge sources on chemical, biological or disease annotations). To augment translational research efforts, the selected candidate will promote the use of and/or contribute to the development of chemical, biological and disease standards that help connect complementary lines of information.

The selected candidate will be expected to create and maintain documentation for methods/workflows to enable their reuse by CTD members or other researchers. Furthermore, he or she will contribute to the establishment of software development and deployment best practices for CTD, including acting as an owner/point of contact for repositories, data systems and servers. The selected candidate will contribute to building a consolidated scientific computing environment through the integration and interoperability of libraries and software and will apply or develop appropriate, state-of-the art methods to support large-scale data-acquisition efforts within the DPI. Active participation in CTD and NCATS committees and meetings, as appropriate, will be encouraged to showcase and obtain feedback (e.g., user feedback) on methods and software developed. The selected candidate will be expected to draft manuscripts and publish results in high-impact, peer-reviewed scientific journals and to present results at internal and external scientific meetings.

Qualifications

The ideal candidate should possess a doctoral degree (M.D., Ph.D. or equivalent) in a relevant field and be a recognized expert in the field. Applicants must possess a broad range of informatics experience that includes at least some of the following: machine learning and/or deep learning (Bayesian inference, probabilistic programming, NLP, TensorFlow, etc.); experience in graph, NoSQL and/or RDBMS databases and semantic data standards (e.g., OWL, RDF); scripting programming for high-throughput data processing and visualization (e.g., R, Python); Linux environments, high-computing servers and cloud computing; versioning systems (GitHub); and full-stack software development. A strong preference will be given to applicants with knowledge of biology and/or chemistry and an understanding of data provenance (e.g., cell biology, methods for measuring multi-omic data, high-throughput screens, biochemistry, genetics). Candidates should have proven experience in analyzing a broad range of data types across different diseases and exploiting these data for therapeutic development.

The selected candidate must have excellent interpersonal and verbal and written communication skills, and he or she must possess excellent analytical, organizational and time-management skills. The desire and drive to seek out and master novel technologies and to develop new ones is expected.

Salary/Benefits

Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (one to two pages); a current curriculum vitae with a complete bibliography; and the names of and contact information for at least three references to NCATSSSRecruit@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Staff Scientist (Chemist), Analytical Chemistry Core, Division of Preclinical Innovation

National Institutes of Health        
National Center for Advancing Translational Sciences        
Division of Preclinical Innovation        
Analytical Chemistry Core        
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates for a scientist (chemist) position in the Analytical Chemistry Core within the center’s Division of Preclinical Innovation (DPI). The scientists within DPI come from a broad range of scientific disciplines — including therapeutic discovery, medicinal chemistry, pharmacology and preclinical development — and work to reduce, remove or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using available resources to conduct nuclear magnetic resonance (NMR) spectroscopy experiments in support of research projects and initiatives. The selected candidate also will be expected to work independently as a well-trained problem solver in NMR spectroscopy. They will perform spectral analysis and interpretation for determining chromatographic and isotopic purity, identifying impurities and verifying structures. The selected candidate will manage, troubleshoot and regularly maintain related instrumentation and equipment. They will train staff on the proper usage of NMR spectrometers and assist in the interpretation of NMR experiments performed by medicinal chemists. The selected candidate also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and standard operating procedures, as well as present work at internal and external meetings.

Qualifications

Each applicant should possess a doctoral degree (Ph.D. or equivalent) in analytical chemistry, chemistry, biochemistry, biophysics or a related discipline with a focus on NMR spectroscopy and be an accomplished expert in the field. Applicants should possess extensive NMR spectroscopy experience, including sample preparation, data analysis, data interpretation and instrument maintenance. Experience working with various chemical modalities ranging from small molecules to proteins is desirable. The ideal candidate should be self-motivated, possess a strong work ethic, have keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

Salary/Benefits

Salary is commensurate with qualifications, experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (one to three pages); a current curriculum vitae and complete bibliography; and the names of and contact information for at least three references to NCATSSSRecruit@mail.nih.gov. The position will remain open for 60 days beginning Dec. 4, 2023.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Program Officer (Program Director), Digital & Mobile Technologies Section, CTSA Program Branch, Division of Clinical Innovation

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Clinical Innovation                           
CTSA Program Branch, Digital & Mobile Technologies Section                           
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates for a program officer (program director) position in the Digital & Mobile Technologies Section of the Clinical and Translational Science Award (CTSA) Program Branch within the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership abilities and demonstrated innovation and expertise in informatics, digital health and/or decentralized clinical research. The CTSA Program is an innovative national network of more than 60 medical research institutions that aims to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research. The Digital & Mobile Technologies Section helps to enable the broader development, implementation and dissemination of digital health and subsequent approaches for decentralized research resources and methods for the CTSA Program.

Core Responsibilities

The program officer/program director (PO/PD) in the Digital & Mobile Technologies Section will oversee and manage CTSA Program cooperative agreements and grants throughout the award cycle. In collaboration with stakeholders within DCI and NCATS, across NIH institutes, centers and offices, and from other federal agencies, the PO/PD will support, develop and implement funding initiatives that address the focus areas of the CTSA Program. The PO/PD will serve as the DCI representative on the CTSA Program Enterprise Committees or Consortium Groups as well as represent NCATS on NIH-wide initiatives and interagency initiatives.

Qualifications

Each applicant should possess an advanced scientific health degree (M.D. and/or Ph.D.) and have extensive knowledge and experience in a relevant scientific discipline. Candidates must have (1) recognizable accomplishments and career progression in a research activity related to health or biomedical/behavioral sciences, as well as competence in management; (2) the ability to communicate effectively to plan, initiate, administer and evaluate a scientific program successfully; (3) familiarity with the dynamics of health-related research; (4) the ability to understand the internal relationships of partner and grantee organizations conducting research, as well as the practices and policies affecting national health research efforts; (5) the ability to work effectively and cooperatively with others; (6) experience developing and maintaining good working relationships with Initial Review Groups, members of National Advisory Councils and Boards, representatives of academic institutions, the scientific community, public and private organizations and agencies, and the general public, as well as supervisors, colleagues and subordinates.

The selected candidate must appreciate the challenges of working with diverse stakeholders and communicating impact clearly to various audiences. The selected candidate should be aware of new and emerging trends in clinical and translational science research and be able to communicate and collaborate well with others.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) — 602 series — or Social Behavioral Scientist (101 series) at the GS 12/13/14 levels; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Interested individuals should submit applications via USAJobs.gov through the Health Science Administrator (601 series), the Physician (Research) — 602 series — or the Social Behavioral Scientist (101 series) at the GS 12/13/14 levels or be considered for a transfer within NIH if currently in these types of positions. This vacancy, open to all U.S. citizens, is advertised under delegated examining (DE) procedures under announcement NIH-GR-DE-23-11936070. This vacancy also is open under merit promotion (MP) procedures under announcement NIH-GR-MP-23-11935760. The USAjobs.gov announcements include additional information regarding medical and scientific specialties, qualification requirements, evaluation criteria and application instructions. Interested individuals also may submit a cover letter describing their interest in the position, current curriculum vitae and complete bibliography to Christopher M. Hartshorn, Ph.D., chief, Digital & Mobile Technologies Section, CTSA Program Branch, Division of Clinical Innovation, via christopher.hartshorn@nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Trial Innovation Network Section Chief, Division of Clinical Innovation, Clinical Affairs Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Clinical Innovation                           
Clinical Affairs Branch                           
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates for a Trial Innovation Network section chief position in the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership and demonstrated expertise in improving clinical trial efficiency through tool development, clinical trial training and education. The selected candidate also will be expected to broaden the scope of clinical trial questions and the clinical trial enterprise so that trials address the health concerns of people in a broad variety of situations and locations, including those living in rural and remote locations, individuals of diverse cultures and beliefs, and minority populations.

The section chief will be responsible for developing a strategy to test, disseminate and incorporate the tools developed by this section and from other parts of the NCATS Trial Innovation Network, ensuring the dissemination and sustainability of these tools within NCATS-funded programs, NIH and the extramural research community. Dissemination should include a variety of organization types and geographic locations. To facilitate this, the Trial Innovation Network section chief will work with clinical trial networks and training programs through NIH and non-NIH programs to ensure that the tools are accessible and used appropriately. This process will be iterative and bilateral, such that suggestions and requests from collaborators will be provided back to the Trial Innovation Network to make sure the needs of participants, families, communities, providers and researchers are optimized. To this end, community engagement will be important to enhance the tool development process, increase uptake and dissemination, and ensure that the necessary types of tools are developed.

Clinical trials are balanced by understanding efficacy/effectiveness and outcome measures, but safety is paramount. Therefore, the section chief will be responsible for tool development that highlights, flags or streamlines safety issues and will lead clinical safety protocol activities within DCI. The position will be within the Clinical Affairs Branch of DCI, which supports the NCATS Trial Innovation Network and The Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®

Core Responsibilities

The Trial Innovation Network section chief will be responsible for providing authoritative, technical and scientific leadership and guidance for the clinical trial activities within DCI and when needed by NCATS and NIH. The section chief will direct the activities of the section, including providing a national resource for rapid response to public health emergencies via the Trial Innovation Network and promoting the identification, development and dissemination of innovative clinical trial designs and recruitment strategies. The section chief will develop and provide resources for the planning, implementation and conduct of NIH-supported clinical trials. The section’s products and resources aim to improve clinical trial efficiency, maximize safety and enhance the types of information within clinical trials. Examples of the activities within the section will include the implementation of techniques/tools to enhance trial design, site selection efficiency, Institutional Review Board efficiency, startup and expansion efficiency, realistic cost, and time calculations for both NIH and investigator expectations, personnel, and site turnover issues.

The section chief will serve as a senior leader, representing DCI and NCATS in clinical, research and clinical trial training/career development programs across NIH, other government agencies, industry, academia and patient-support organizations. The section chief will provide advice to the clinical affairs branch chief and the DCI director on trial-, safety- and clinical-related matters. The section chief will also work to diversify the clinical trial landscape by working in coordination with the various components of DCI, including the Education and Training Section of the Clinical and Translational Science Awards (CTSA) Program Branch. The CTSA Program Branch supports the CTSA Program, an innovative national network of more than 60 medical research centers that aims to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research.

Qualifications

The successful candidate will have a Medical Doctorate (M.D.), an active state medical license, and real-world experience in academia or industry in clinical trial development and conduct. The successful candidate will have experience in trial bottlenecks/barriers, optimization strategies and potential efficiencies. An important aspect of the position will be safety; therefore, the successful candidate will have extensive experience with clinical safety issues. The successful candidate also will have strong and demonstratable experience in conceiving, developing and testing tools to support clinical trials in novel groups and settings. The successful candidate will also have a strong history of working with diverse federal and nonfederal organizations and partners.

The successful candidate must have extensive experience in (1) leading a diverse, highly complex research program and employing strategies for implementing and disseminating research tools and products; (2) providing expert advice to senior leaders on scientific and clinically relevant policies and programs; (3) developing innovative training programs for advancing clinical tool development, dissemination and usage by trainees; and (4) leading teams. The successful candidate must appreciate new trends in the clinical trial enterprise, such as the novel use of informatics, big data and site-selection strategies to improve the conduct of trials. The successful candidate will have the ability to communicate and collaborate well with others.

Candidates should demonstrate (1) a clear pattern of success in setting, planning, implementing and analyzing research projects, program objectives and priorities; (2) the ability to communicate and collaborate effectively with diverse scientific and lay audiences; and (3) the ability to form collaborations with national and international organizations, as well as with individuals who represent wide-ranging disciplines and competing priorities.

Salary/Benefits

Salary is commensurate with qualifications, experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Interested individuals should apply from May 24 to June 23, 2023 (submission deadline may be extended if needed) by submitting (via email) a cover letter describing their interest in the position and a curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to NCATSSBRBPASPosition@nih.gov. Include your name and name of the position in the subject line. Please submit questions about this position to Salina Waddy, M.D., via salina.waddy@nih.gov. Review of applications will begin June 24, 2023, and continue until the position is filled. Do not include your birthdate or social security number on application materials.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Program Officer (Program Director), Trial Innovation Network Section, CTSA Clinical Affairs Branch, Division of Clinical Innovation

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Clinical Innovation                           
CTSA Clinical Affairs Branch, Trial Innovation Network Section                           
Bethesda, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates for a program officer (program director) position in the Clinical Affairs Branch, Trial Innovation Network (TIN) Section within the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership abilities and demonstrated expertise in improving clinical trial efficiency through tool development, regulatory science in clinical trials, health disparities/equity trials, community engagement, and clinical trial training and education. The selected candidate also will be expected to broaden the scope of clinical trial questions and the clinical trial enterprise so that trials address the health concerns of people in a broad variety of situations and locations, including those living in rural and remote locations, individuals of diverse cultures and beliefs, and minority populations.

The TIN develops trial efficiency tools to test, disseminate and incorporate the tools developed by this section and other parts of the NCATS TIN, ensuring the dissemination and sustainability of these tools within NCATS-funded programs, the Clinical and Translational Science Awards (CTSA) Program, NIH and the extramural research community. To facilitate this, the TIN program officer (program director) will work with clinical trial networks and training programs through NIH and non-NIH programs to ensure the tools are accessible and used appropriately. This process will be iterative and bilateral, so suggestions and requests from collaborators will be provided back to the TIN to ensure the needs of participants, families, communities, providers and researchers are optimized. To this end, community engagement will be essential to enhance the tool development process, increase uptake and dissemination and ensure that the necessary tools are developed. The TIN also supports the Helping to End Addiction Long-term® Initiative or NIH HEAL Initiative®.

Core Responsibilities

The program officer (program director) will be responsible for project and network activities and coordinating a toolkit for investigators to use TIN tools. The section’s products and resources aim to improve clinical trial efficiency, maximize safety and enhance the types of information within clinical trials. Examples of the activities within the section will include implementing techniques and tools to enhance trial design, site selection efficiency, Institutional Review Board efficiency, startup, and expansion efficiency, for both NIH and investigator expectations, personnel and site turnover issues. The program officer (program director) will manage cooperative agreements and programs within the TIN and develop trial-related initiatives to improve the efficiency of the clinical trial enterprise and work with TIN investigators on trial-related workgroups.

Qualifications

Each applicant should possess an advanced scientific health degree (M.D. and/or Ph.D.) and have extensive knowledge and experience in clinical research and knowledge of regulatory science related to clinical trials. Candidates must have (1) recognizable accomplishments and career progression in a research activity related to health or biomedical/behavioral sciences, as well as competence in program management with extensive experience as a program director; (2) the ability to communicate effectively to plan, initiate, administer and evaluate a scientific program successfully; (3) knowledge in the dynamics of health-related research including regulatory science; (4) the ability to understand the internal relationships of partner and grantee organizations conducting research, as well as the practices and policies affecting national health research efforts; (5) the ability to work effectively and cooperatively with others; (6) experience developing and maintaining good working relationships with review groups, members of national advisory councils and boards, representatives of academic institutions, the scientific community, public and private organizations and agencies, and the general public, as well as supervisors, colleagues and subordinates.                           

The selected candidate must appreciate the challenges of working with diverse stakeholders and communicating impact clearly to various audiences. The selected candidate should be aware of new and emerging trends in clinical and translational science research and be able to communicate and collaborate well with others.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) — 602 series — or Social Behavioral Scientist (101 series) at the GS 14 level; a full civil service package of benefits — including retirement; health, life, and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Interested individuals should submit applications via USAJobs.gov through the Health Science Administrator (601 series), the Physician (Research) — 602 series — or the Social Behavioral Scientist (101 series) at the GS 14 level or be considered for a transfer within NIH if currently in these types of positions.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).                           

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Senior Medicinal Chemist (Staff Scientist), Division of Preclinical Innovation, Therapeutics Development Branch, Medicinal Chemistry Group

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutics Development Branch                           
Medicinal Chemistry Group                           
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from exceptional candidates to fill a senior medicinal chemist (staff scientist) position in the Therapeutic Development Branch (TDB) within its Division of Preclinical Innovation (DPI) in Rockville, Maryland. The selected applicant will manage Investigational New Drug–enabling drug development projects involving collaborations with other NIH institutes, centers and offices; academic scientists; and industry and nonprofit organizations.

The scientists within DPI come from a broad range of scientific disciplines — including therapeutic discovery, medicinal chemistry, pharmacology and preclinical development — and work to reduce, remove or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce. This position will require a strong understanding of all aspects of medicinal chemistry and related disciplines to be able to advance projects from lead identification to the development of candidate selection. The senior medicinal chemist will work with project teams to define project goals and go/no-go criteria and manage timelines and chemistry resources to drive projects toward key decision criteria.

Core Responsibilities

The selected candidate will lead projects at various stages, from lead generation through clinical candidate nomination, and will be responsible for designing, implementing and executing synthetic and medicinal chemistry strategies; developing new technologies to accelerate drug discovery; presenting results in internal and external meetings; and writing reports and manuscripts. Research will be conducted in the TDB medicinal chemistry group.

Qualifications

Applicants should possess a doctoral degree (M.D., Ph.D. or equivalent) in organic chemistry or medicinal chemistry, with at least 10 years of experience working in drug discovery or related fields. A strong background in synthetic organic chemistry is required. Experience in synthesis of complex small molecules, including natural products and designer molecules, is highly desirable. Candidates with experience in developing new methods or technologies highly relevant to the broad field of drug development will be considered favorably. Applicants should be able to lead medicinal chemistry projects and have a strong track record of scientific innovation and success in delivering clinical candidates. The ideal applicant should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. The applicant should possess strong oral and written communication skills, with a proven publication record in peer-reviewed journals.

Salary/Benefits

Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit a cover letter describing your interest in the position, including a career synopsis (one to three pages); a current curriculum vitae and complete bibliography; and the names of and contact information for three references to Wenwei Huang, Ph.D., via ncatsssrecruit@mail.nih.gov. The position will remain open for 30 days beginning April 7, 2023. To learn more about the Therapeutics for Rare and Neglected Diseases (TRND) program, visit https://ncats.nih.gov/trnd.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Research Associate (Biology), Division of Preclinical Innovation, Chemical Technologies Group

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Chemical Technologies Group                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research associate (biology) position in the Chemical Technology group within its Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal and process chemists, and computational scientists who work on a broad portfolio of preclinical drug discovery projects, as well as programs that involve the development of innovative new technologies to enable the acceleration of biomedical research. The Chemical Technology group operates at the interface between chemistry and biology. A major focus of the team involves conducting large-scale chemogenomic screenings to identify novel targets and to develop novel strategies for therapeutic intervention, mostly focusing on oncologic indications. A second major focus of the team involves the discovery, optimization and advancement of novel biologically active small molecules.

Core Responsibilities

The selected candidate will maintain mammalian cell-line cultures and expand them to scale in preparation of high-throughput drug screening; prepare various media, stock supplies and other reagents for use in the laboratory; perform in vitro cell-based assays to support the molecular characterization of drugs’ mechanism of action. These include DNA/RNA extraction, PCR and western-blot. The selected applicant also will maintain accurate daily records of experiments and results and interpret, evaluate and discuss the result of each experiment as part of the experimental-planning process. The selected candidate will perform computer analysis of data and use various software to prepare data figures for both internal discussion and publication.

Qualifications

Applicants to this research associate (biology) position should possess a bachelor's degree in biology, biochemistry or other related life science discipline. A master’s in cell biology, immunology, biochemistry or other related life science discipline is preferred. The selected candidate should possess a conceptual understanding of cancer biology and knowledge of major oncogenic signaling pathways in human cancers, a strong background in cell biology, have at least two years of previous experience with standard molecular biology techniques (e.g., tissue culture, RNA and DNA extraction, PCR and western-blot) and be proficient at the bench. He or she should demonstrate attention to detail and possess strong organizational and interpersonal skills. Applicants also should possess excellent verbal and written communication skills, the ability to interpret, summarize and present scientific results in a clear, concise and accurate manner; and be able to work productively as a member of a diverse and dynamic multidisciplinary team.

The ideal candidate will have previous experience with high-throughput drug screening, Illumina next-generation sequencing platforms and related library preparation procedures (especially RNA-Seq and single-cell analysis), as well as documented knowledge of the hippo signaling pathway. Previous experience in microscopy, immunocytochemistry and flow cytometry, as well as strong computer literacy and Microsoft Excel proficiency — particularly with respect to graph/plots generation and analysis of large data sets — will be considered a plus.

Salary/Benefits

Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to ncatspt3hiring@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Research Scientist (Virology) Position, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research scientist (virology) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge technologies — including tissue biofabrication, tissue chips, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies (e.g., scRNAseq) — to develop advanced 3-D cellular models to study viral infections and drug screening. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. The selected candidate also will be expected to work independently as a well-trained problem solver in virology. Effective communication and presentation skills are required. The selected applicant will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The selected candidate will draft technical reports, manuscripts and patent applications, and present work to internal and external collaborators as needed. The selected candidate also should be eligible to work in the U.S. with whomever NCATS collaborates worldwide.

Qualifications

Applicants to this research scientist position should possess a Ph.D. in virology, cell or molecular biology or pharmacology, and at least three years of postdoctoral experience. The selected candidate should have expertise in virology to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and drug testing. Applicants should have additional expertise in histology, fluorescence microscopy, flow cytometry, single-cell RNA sequencing (scRNAseq), and production of induced pluripotent stem cell-derived cells. Candidates with previous experience working in a BSL3 lab and in areas such as organoids, tissue chip, cell imaging, histology and engineering of cells with biosensors will be considered favorably.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Bioinformatician, Division of Preclinical Innovation, Chemical Genomics Branch, Stem Cell Translation Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Chemical Genomics Branch                           
Stem Cell Translation Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a bioinformatician position in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as induced pluripotent stem cells, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems.

The successful candidate will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS and collaborators at top academic institutions.

Core Responsibilities

Computational analysis is integral to the laboratory’s efforts in the deep characterization of stem cell states and functional cell types from different developmental lineages. The bioinformatician will be required to promptly turn around analysis results to respond to biologists’ ongoing projects, work on multiple projects in parallel, and coordinate and oversee data analysis with external service providers.

Qualifications

Applicants should have a master’s degree or higher in bioinformatics, computational biology or biomedical data science. The ideal candidate should have strong science communication skills; clear and effective data visualization skills; the ability to work well independently and in a team environment; creative problem-solving skills; and a proven ability to apply the cutting-edge, rigorous standards of the bioinformatics fields. Applicants should possess a solid knowledge of R statistical programming language; familiarity with the handling, management and storage of large-scale sequencing data; and experience querying public databases, including the SRA, GEO and dbGaP.

Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms (e.g., bulk and single-cell RNA-Seq; ChIP-seq methods, such as MeDIP-seq; bulk and single-cell ATAC-seq; and miRNA-seq). Experience with other ‑omics — such as WES, WGS and targeted sequencing methods — are a plus. The ideal candidate will have experience with preprocessing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, HTSeq, featureCounts, salmon, GATK) and R packages designed for the above-mentioned methods (e.g., DESeq2, limma, Seurat). A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of NIH’s high-performance computing capabilities, are preferred.

Salary/Benefits

Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Positions in the Division of Preclinical Innovation

The Division of Preclinical Innovation (DPI) is the intramural (i.e., on-site) research program of NCATS and is located in Rockville, Maryland, a few miles from the main NIH campus in Bethesda, Maryland. DPI focuses on early stages of the translational process, from target validation to first-in-human studies. More than 200 scientists from a variety of disciplines and across the spectrum from early-career scientists to senior leaders are responsible for advancing the diverse research portfolio of DPI. In addition to conducting cutting-edge laboratory research, DPI scientists collaborate with more than 250 research organizations worldwide.

DPI scientists work in a collaborative, team-based environment. The postdoctoral candidate will be recruited to work on the specific projects described below and will have ample opportunities to collaborate with scientists both within and outside of NCATS on additional projects. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Postdoctoral fellows also gain additional professional skills and exposure to a variety of career paths through participation in the DPI training program.

Postdoctoral Fellow (Chemical Biology/Molecular Pharmacology), Assay Development and Screening Technology Laboratory, Division of Preclinical Innovation

National Institutes of Health            
National Center for Advancing Translational Sciences            
Division of Preclinical Innovation            
Assay Development and Screening Technology Laboratory            
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral fellowship position within the Assay Development and Screening Technology (ADST) laboratory of James Inglese, Ph.D., within the center’s Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal chemists and computational scientists who work on a broad portfolio of preclinical drug discovery projects and with programs that involve developing innovative new technologies to enable the acceleration of biomedical research.

The ADST laboratory is interested in discovering and developing novel molecular modalities for a variety of therapeutic indications — including cancer — with particular emphasis on rare metabolic disease applications. The current focus is on the evaluation of antifolate-based proteolysis targeting chimera chemical libraries to define target profiles and underlying mechanisms of action. This research will involve the design and implementation of CRSIPR/Cas9 genome edited reporter cell lines to interrogate the molecular pharmacology and biochemical network of one-carbon metabolism using these chemical libraires. Compounds of interest will be characterized using proteomics and metabolomics analysis and, depending on their properties, assessed in synthetic lethality functional genomics and conditional combination drug screens. Candidate molecules displaying novel pharmacology will enter a collaborative therapeutic development program involving medicinal chemistry optimization accompanied by relevant in vivo cancer or relevant models associated with rare disorders.

Recent research from this laboratory relevant to the position can be found at https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00333-1.

For more information about the laboratory, see https://www.youtube.com/watch?v=VxtpySnbX-c and https://ncats.nih.gov/about/divisions-and-staff/jinglese.

Core Responsibilities

The successful applicant will have the opportunity to use an interdisciplinary approach to pursue research interests as they advance to an independent research career in the supportive intramural environment of the NCATS laboratories in Rockville, Maryland, which also includes core facilities specializing in automated high-throughput screening, synthetic organic chemistry, functional genomics, proteomics, advanced microscopy, biochemistry, human induced pluripotent stem cells, cheminformatics and bioinformatics.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have fewer than 3 years of postdoctoral experience in chemical biology, molecular pharmacology or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply. The selected candidate should be an independent thinker and team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to James Inglese, Ph.D., at NCATS2024Postdoc@mail.nih.gov. Please direct questions regarding this position or the application process to Ms. Carrie Watkins at watkinsc@mail.nih.gov.

The review of applications will begin in spring 2024 and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Computational Biologist/Bioinformatician), Division of Preclinical Innovation, Therapeutics Development Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                                    
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (computational biologist/bioinformatician) position in the Biology Group of the Therapeutic Development Branch (TDB) within the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. DPI routinely partners with external collaborators from universities, pharmaceutical and biotechnology companies, and disease research foundations to form multidisciplinary project teams with expertise in assay development, high-throughput screening, bioinformatics analysis, medicinal chemistry, disease-relevant biological models and preclinical drug development. As such, the TDB Biology Group is looking for a self-motivated postdoctoral fellow to work in a highly creative and collaborative team environment — with a focus on bioinformatics and -omics data analysis — to advance drug discovery and drug development projects.

Research conducted by members of the TDB Biology Group has a broad focus and spans multiple disease areas, including genetic diseases (e.g., lysosomal storage disorders, neuronal diseases, cancer) and infectious diseases. The team is applying patient-derived induced pluripotent stem cell (iPSC) disease models, including 2-D cells and 3-D organoids, to study disease pathophysiology and evaluate drug efficacy.

Core Responsibilities

The selected candidate will learn and apply advanced computational techniques and methods for translational research. The fellow will perform bioinformatic analysis of the compound screening data and -omics profiling data, including RNAseq and proteomics data. The fellow also will have the opportunity to develop and employ AI-based models for virtual compound screening, as well as AI-based modeling for biomarker development. They will learn and participate in the drug development process and will collaborate with researchers from other NIH institutes and centers, as well as with academic institutions with which NCATS collaborates. The selected candidate will present experimental findings at scientific conferences. Upon completion of training, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities.

The fellow will communicate results to project team members and collaborators and provide updates to senior management. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The fellow also will write technical reports and manuscripts.

Qualifications

The ideal candidate should possess a doctoral degree (Ph.D.) with a background in biology, computer science, bioinformatics or a related discipline. Previous experience in -omics data analysis, AI-based computational modeling/virtual screening, and/or compound screening data analysis is preferred. The candidate should have a strong record of publishing research results in high-impact, peer-reviewed scientific journals. Applicants should be independent thinkers and team players who are able to work in an interactive and fast-paced environment. The selected candidate is expected to present results of ongoing work at meetings (e.g., internal group meetings, project team meetings, national conferences) and submit their work for publication in peer-reviewed scientific journals. Therefore, effective communication and presentation skills are required. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email PDF versions of (1) a cover letter that includes a research summary and describes your interest in the position and (2) a current curriculum vitae with a complete bibliography, as well as contact information for two or three references, including your current supervisor, to Catherine Chen, Ph.D., at catherine.chen@nih.gov.

The review of applications will begin immediately and continue until the position is filled

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Biologist), Division of Preclinical Innovation, Therapeutic Development Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
Biology Group                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (biologist) position in the Biology Group of the Therapeutic Development Branch (TDB) within the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. DPI routinely partners with external collaborators from universities, pharmaceutical and biotechnology companies, and disease research foundations to form multidisciplinary project teams with expertise in assay development, high-throughput screening (HTS), bioinformatics analysis, medicinal chemistry, disease-relevant biological models and preclinical drug development. As such, the TDB Biology Group is looking for self-motivated postdoctoral fellow to work in a highly creative and collaborative team environment to advance drug discovery and drug development projects.

Research conducted by members of the TDB Biology Group has a broad focus and spans multiple disease areas, including genetic diseases (e.g., lysosomal storage disorders, neuronal diseases, cancer and infectious diseases).

Core Responsibilities

The selected candidate will develop in vitro biochemical and cell-based assays for HTS of compound libraries to identify lead compounds, which will be used as tools to further understand disease pathophysiology and to be developed as therapeutics. They will learn and participate in the drug development process and will apply new technologies such as patient-induced pluripotent stem cell (iPSC)-based disease modeling and 3-D organoids for evaluation of drug efficacy and toxicity. The fellow will collaborate with researchers from other universities and NIH institutes and centers, and he or she will present experimental findings at scientific conferences. Upon completion of orientation and training, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities.

The fellow will communicate results to project team members and collaborators and provide updates to senior management. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The fellow also will write technical reports and manuscripts.

Qualifications

The ideal candidate should possess a doctoral degree (Ph.D.) with a background in cell biology, molecular biology or pharmacology, and have a strong record of publishing research results in high-impact, peer-reviewed scientific journals. Experience in human iPSC-related research or drug screening is preferred, although training in these areas will be provided. Applicants should be independent thinkers and team players who are able to work in an interactive and fast-paced environment. Candidates are expected to present results of ongoing work at meetings (e.g., internal group meetings, project team meetings and national conferences) and submit their work for publication in peer-reviewed scientific journals. Therefore, effective communication and presentation skills are required. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email (in PDF format) a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for two to three references, including your current supervisor, to Catherine Chen, Ph.D., at catherine.chen@nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Pharmacokinetics Modeling Postdoctoral Fellow, Division of Preclinical Innovation, Drug Metabolism and Pharmacokinetics Core

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Drug Metabolism and Pharmacokinetics Core                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional scientists for a postdoctoral fellow position in physiologically based pharmacokinetic (PBPK) modeling — for preclinical development projects involving drug metabolism and pharmacokinetics (DMPK) — within the center’s Division of Preclinical Innovation.

The DMPK Core partners with academic institutions, foundations and private industry to conduct preclinical discovery and development studies leading to Investigational New Drug (IND) applications for new therapeutics. These projects play a leading role in NCATS’ mission to develop new ways to reduce, remove or bypass bottlenecks across the continuum of translational science and address rare and neglected diseases.

Core Responsibilities

The selected candidate will collaborate with team members to conduct in vitro absorption, distribution, metabolism and elimination (ADME) and in vivo pharmacokinetic (PK) studies and develop PBPK models for assigned projects. Specific duties include independently performing in vitro ADME testing, conducting in vivo PK studies in laboratory animals, and developing PBPK models for NCATS drug development projects. These PBPK models will be used to guide the selection of lead drug candidates and predict human PK profiles prior to the clinical trials. The selected candidate will disseminate their research by publishing results in peer-reviewed journals and participating in scientific conferences and meetings.

Qualifications

Applicants to this postdoctoral fellow position should hold a Ph.D. in pharmaceutical science, pharmacology, pharmacokinetics or computer science — with a focus on drug development or a related life science field — and have a proven track record of in vitro and in vivo drug metabolism and pharmacokinetic studies. Applicants should possess excellent skills in quantifying novel drug molecules in serum/plasma or tissues and demonstrate solid knowledge in quantitative method development and data interpretation. Candidates with advanced knowledge and skills in high-performance liquid chromatography, mass spectrometry, in vitro ADME and PK studies, and computational modeling will receive preferential consideration.

The selected candidate should possess strong oral and written communication skills and excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner. The selected candidate will be expected to demonstrate a proven ability to collaborate with colleagues to achieve project, team and organizational goals.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter describing your interest in the position, including a career synopsis (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Xin Xu, Ph.D., at xin.xu3@nih.gov. The review of applications will begin on May 15, 2023, and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Biomedical Engineer), Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (biomedical engineer) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. The selected candidate must have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology and fluorescence microscopy, as well as experience working with primary cells or induced pluripotent stem cell-derived cells.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies, such as scRNA-seq — to develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including the architectural and physiological validation of tissues. Effective communication and presentation skills are required. The selected candidate will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed. The selected candidate must be eligible to work in the United States with NCATS collaborators worldwide.

Qualifications

Applicants to this postdoctoral position must possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in such areas as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology, and engineering of cells with biosensors — will be considered favorably.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for two to three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Molecular Biologist), Division of Preclinical Innovation, Therapeutics Development Branch, RNA Therapeutics Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
RNA Therapeutics Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (molecular biologist) position in the RNA Therapeutics Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. As a member of a dynamic, dedicated and multidisciplinary team of researchers committed to developing therapies for rare disorders, the selected candidate will work on innovative drug discovery projects to develop antisense oligonucleotide (ASO) therapies that can benefit patients and families affected by rare diseases.

Core Responsibilities

The selected candidate will be responsible for designing and developing 2-D and organoid assays to predict various types of toxicity (e.g., neurotoxicity, hepatotoxicity) associated with ASO therapies. The fellow will design and conduct experiments, analyze data, write reports and present research findings at scientific meetings and in peer-reviewed publications. The selected candidate also will collaborate with other members of the research team, as well as external partners, to advance the goals of the RNA Therapeutics Laboratory.

Qualifications

Applicants should have (or expect to receive) a Ph.D. in biochemistry, molecular biology or a related field at the time of joining the laboratory. The ideal candidate should be self-motivated, collaborative and team-orientated, with a strong work ethic and keen attention to detail. The candidate should possess strong oral and written communication skills and a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Bryan J. Traynor, M.D., Ph.D., at traynorb@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Fellow (Synthetic Chemist), Division of Preclinical Innovation, Therapeutic Development Branch, Medicinal Chemistry Group

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
Medicinal Chemistry Group                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks a highly motivated synthetic chemist to serve as a postdoctoral fellow in the Therapeutic Development Branch (TDB) within its Division of Preclinical Innovation (DPI) in Rockville, Maryland. The selected candidate will work on drug discovery projects as part of a multidisciplinary team to identify clinical candidates to address unmet medical needs.

Core Responsibilities

The postdoctoral fellow will be responsible for designing and synthesizing compounds for structure–activity relationship and structure–property relationship studies, developing new technologies to accelerate drug discovery, presenting results in internal and external meetings, and writing reports and manuscripts. Research will be conducted in the TDB medicinal chemistry group.

Qualifications

Applicants should have (or expect to receive) a Ph.D. in organic or medicinal chemistry at the time of joining the laboratory. The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail and be able to work on multiple projects simultaneously. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Wenwei Huang, Ph.D., at huangwe@mail.nih.gov.The review of applications will begin immediately and continue until the position is filled. .

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Systems Toxicology Postdoctoral Fellow, Division of Preclinical Innovation, Toxicology in the 21st Century (Tox21) Program

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Toxicology in the 21st Century (Tox21) Program                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral fellow position in the Toxicology in the 21st Century (Tox21) program within its Division of Preclinical Innovation. To meet the challenges of toxicology research in the 21st century, NCATS has partnered with the National Toxicology Program, the U.S. Food and Drug Administration and the U.S. Environmental Protection Agency to form the Tox21 program. Since 2010, this program has utilized a quantitative high-throughput screening approach to assess a 10,000-compound (10K) library using a group of biologically and toxicologically relevant in vitro assays. The data generated from the screening will be used to prioritize chemicals for further in-depth toxicological evaluation, identify mechanisms of chemical toxicity and develop predictive models for in vivo biological response in humans.

The selected postdoctoral fellow should be self-motivated and prepared to work on Tox21 research projects to develop physiologically relevant assays for assessment of environmental chemicals. NCATS provides a unique and exciting environment that employs state-of-art technologies enabling assay development, chemical screening and profiling for toxicology research.

Core Responsibilities

The postdoctoral candidate will develop in vitro cell-based assays using physiologically relevant cell models (primary cells, stem cell/ induced pluripotent stem cell-derived cells, and 3-D cell/organoid models) with biotransformation-capability for screening chemicals. The fellow will apply new technologies including 3-D cell/organoid models and high-content phenotypic profiling using cell-based imaging assays for evaluating chemical toxicity. The fellow will perform follow-up studies (e.g., mechanisms of compound action) after the primary screening. The fellow also will interact regularly with informatics scientists to aid data analysis and interpretation.

Qualifications

Applicants should hold a doctoral degree (M.D., Ph.D. or equivalent) in the life sciences (e.g., toxicology, pharmacology, biology, cell biology, biochemistry or a related field is preferred) with solid  understanding of toxicology, cell biology or general aspects of signal transduction. A strong preference will be given to applicants with prior experience in in assay development, including biotransformation-capable assays, imaging technology or compound screening. He or she should possess data analysis skills and familiarity with Excel spreadsheets. The applicant must possess strong oral and written communication skills, with a proven publication record in peer-reviewed journals. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Menghang Xia, Ph.D. at mxia@mail.nih.gov. Applicants also should indicate when they are available to start.

The review of applications review will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Biology Postdoctoral Position, Division of Preclinical Innovation, Early Translation Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Early Translation Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment within the ETB. He or she will use cutting-edge cell biology and bioassay technologies to develop disease-relevant screening assays and will be involved in all aspects of implementing small molecule screening programs, including assay design, assay development and optimization, high-throughput screening, data analysis, and mechanism-of-action studies to develop assay technologies and novel pharmacological probes.

Core Responsibilities

The postdoctoral candidate will need to have training in drug screening. This project includes the study of a new platinum agent for clinical development, along with an ambitious goal of screening and discovering new uses for platinum chemotherapeutic agents. The trainee will bring experience in cell biology or bioinorganic chemistry and learn to work in a team-based world-class drug discovery environment. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, bioinorganic chemistry, pharmacology, or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply; prior high-throughput screening experience is not a prerequisite. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATS ETB Careers at ncatsetbcareers@mail.nih.gov. Applicants also should indicate when they are available to start. Please note that the starting date of the fellowship is flexible, preferably within 2023.

The review of applications review will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Biology Postdoctoral Position, Division of Preclinical Innovation, Early Translation Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Early Translation Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment within the ETB. He or she will use cutting-edge cell biology and bioassay technologies to develop disease-relevant screening assays and will be involved in all aspects of implementing small molecule screening programs, including assay design, assay development and optimization, high-throughput screening, data analysis, and mechanism-of-action studies to develop assay technologies and novel pharmacological probes.

Core Responsibilities

The postdoctoral candidate will work on a project that includes the study of an understudied target class of enzymes, with the goal of SAR profiling the target class to promote probe development. Successful candidates will have a background in biochemistry, molecular biology, or cellular biology. Enzymology experience is preferred. Experience with drug screening and informatics are useful, but not required. The trainee will learn to work in a team-based world-class drug discovery environment. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, biochemistry, or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply; prior high-throughput screening experience is not a prerequisite. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATS ETB Careers at ncatsetbcareers@mail.nih.gov. Applicants also should indicate when they are available to start. Please note that the starting date of the fellowship is flexible, preferably within 2023.

The review of applications review will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Bioanalytical Chemistry Postdoctoral Fellow, Division of Preclinical Innovation, Drug Metabolism and Pharmacokinetics Core

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Drug Metabolism and Pharmacokinetics Core                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional scientists to serve as a postdoctoral fellow in bioanalytic assay development for therapeutical biologics — for preclinical development projects involving drug metabolism and pharmacokinetics (DMPK) — within the center’s Division of Preclinical Innovation.

The DMPK Core partners with collaborators (academic institutions, foundations and private industry) to conduct preclinical discovery and development studies leading to Investigational New Drug (IND) applications for new therapeutics. These projects play a leading role in NCATS’ mission to develop new ways to reduce, remove or bypass bottlenecks across the entire continuum of translational science and to address rare and neglected diseases.

Core Responsibilities

The selected candidate will collaborate with team members to evaluate, develop and implement bioanalytical assays to quantify therapeutical biologics and its carriers in blood and tissues for assigned projects. Specific duties include providing bioanalytical strategies for novel therapeutical biologics, such as peptides, conjugated peptides, monoclonal antibodies, engineered human proteins, antibody-drug conjugates, oligonucleotides, mRNAs, gene therapies and other novel modalities. The selected candidate also will be responsible for generating specific reagents for the assay development and will collaborate with biologists and researchers across different teams within NCATS to address project-specific needs. Additional duties include quantitatively analyzing biological samples collected from preclinical pharmacokinetic and biodistribution studies, preparing documents for the regulatory filing purpose, and disseminating research via peer-reviewed publications and participating in scientific conferences and meetings.

The selected candidate should possess strong oral and written communication skills and excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner. The selected candidate will be expected to demonstrate a proven ability to collaborate with colleagues to achieve project, team and organizational goals.

Qualifications

Applicants to this postdoctoral fellow position should hold a Ph.D. in biology, immunology, biochemistry, analytical chemistry, proteomics, pharmaceutical science or a related field and have a proven track record of quantitative bioanalytical method development (e.g., ligand binding assays); excellent skills to quantify active biologics in serum/plasma or tissues; and a solid knowledge in method validation and data interpretation. Candidates with advanced knowledge and skills in high-performance liquid chromatography, mass spectrometers, electrochemiluminescence ligand binding device  or related instruments will receive preferential consideration. Applicants with experience working on qPCR, TR-PCR, proteomics sample preparation and immunogenicity assessment will be considered favorably. Candidates also should have strong oral and written English communication skills and be able to work in a highly collaborative team setting.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please email a cover letter describing your interest in the position, including a career synopsis (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Xin Xu, Ph.D., at xin.xu3@nih.gov. The review of applications will begin on July 1, 2022, and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Computational Toxicology/Informatics Postdoctoral Fellow Position, Division of Preclinical Innovation, Computational Toxicology Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Computational Toxicology Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a computational toxicology/informatics postdoctoral position in the Computational Toxicology Laboratory within the center’s Division of Preclinical Innovation (DPI). To meet the challenges of toxicology research in the 21st century, NCATS has formed a partnership  with the National Toxicology Program, the U.S. Food and Drug Administration, and the U.S. Environmental Protection Agency to develop a high-throughput screening (HTS) program. The goals of the Toxicology in the 21st Century (Tox21) program are to prioritize chemicals for further in-depth toxicological evaluation, identify mechanisms of chemical toxicity and develop predictive models for in vivo biological response in humans. NCATS has a unique and exciting environment that employs state-of-art technologies for assay development, chemical screening and profiling for toxicology research.

Core Responsibilities

The selected candidate will engage in several activities, including analyzing large data sets generated from HTS assays; developing novel methods to identify and prioritize toxicity response pathways for assay development and compound testing; building predictive models for different in vivo toxicity endpoints using chemical structural data, genomic data and in vitro assay data; and generating testable hypotheses on compound mechanisms of toxicity. The candidate should be familiar with public genomic and genetic databases and be capable of data mining using complex data sets. The successful candidate also should have experience building and integrating genomic databases and working at the interface of genomic and chemoinformatic information. The fellow will work closely with informatics scientists and biologists in the DPI to aid in data interpretation and project development.

Qualifications

Applicants to this position should possess a Ph.D. in the biomedical sciences, extensive experience with one or more programming languages, and knowledge in database queries and data retrieval. A background in cheminformatics or bioinformatics, biology, chemistry or toxicology is preferred. Experience in 2-D or 3-D modeling, large data set manipulation or data mining is a plus. The ideal candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit (via email) a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Ruili Huang, Ph.D., at huangru@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Neuroscientist Postdoctoral Fellow Positions, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill neuroscientist postdoctoral fellow positions in the Division’s 3-D Tissue Bioprinting Laboratory. The selected candidates will develop human functional neural 3-D tissue models as assay platforms for the discovery and development of new therapeutics for pain, addiction or overdose. Applicants with a background in neurosciences, in vitro neural organotypic models and neural stem cells will receive preferential consideration.

Core Responsibilities

The selected candidates will work as part of a multidisciplinary team of innovative scientists with expertise in bioengineering, 3-D bioprinting, quantitative cell imaging, electrophysiology, histology, assay development, drug screening, data science and other cutting-edge “omics” technologies. The selected candidates will develop and characterize functional 3-D neural organotypic assays for drug discovery and development.

Qualifications

Applicants to these postdoctoral fellow positions should possess a Ph.D. in neuroscience, cell biology, molecular biology, pharmacology, pathology or a related discipline with relevant experience in neuroscience, physiology and pathology of the nervous system to help establish a portfolio of assays to model neural circuitry of pain, addiction and overdose. The ideal candidates will be expected to work independently as well-trained problem solvers in the production of 3-D neural organotypic models, including architectural and physiological validation, and develop functional assay readouts for drug screening. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Experience in techniques necessary to develop CNS and PNS assays for drug testing using tissues, including extracellular electrophysiological recording (field potential or multi-unit), calcium imaging, neural stem cell and primary cell culture and associated analysis is required. Experience with techniques such as histology, quantitative analysis of microscopy images, time-lapse microscopy is highly desired. Candidates with additional experience in physiology and pathology of pain, addiction or overdose, optogenetics microscopy, or tissue engineering or bioprinting techniques will receive preferential consideration. Each candidate should be an independent thinker and team player able to work and multitask in a highly interactive, fast-paced environment. The ideal candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit (via email) a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information of at least three references to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and continue until these positions are filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Bioinformatics Position, Division of Preclinical Innovation, Informatics Core

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Informatics Core                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral bioinformatics position in the Informatics Core (IFX) within the Division of Preclinical Innovation.                           

The IFX is an interdisciplinary team of bioinformaticians, clinical informaticians, cheminformaticians and software engineers who collaborate closely with molecular biologists to augment the use of metabolomics and multi-omics analysis approaches to identify dysregulated pathways and putative therapeutic targets.

Core Responsibilities

The selected candidate — a postdoctoral fellow in bioinformatics — will have a solid foundation in bioinformatics and biostatistics, including machine learning, and experience in cleaning, processing, and integrating metabolomic and other -omic datasets. He or she will develop novel bioinformatics methods to optimize the predictive capacity of metabolomics and -omic (e.g., proteomic, transcriptomic) profiles in differentiating groups (e.g., cell characteristics, individuals). These novel approaches will augment the bioinformatics field by addressing issues not addressed by standard approaches. The selected candidate will interact closely with computational and noncomputational (e.g., biologists, chemists, clinicians) IFX and NCATS scientists and our academic collaborators. In addition to working independently on collaborative translational research projects, the fellow also would be involved in building a computational infrastructure for the QC, analysis and interpretation of metabolomic and multi-omic profiles. He or she will be expected to draft manuscripts and publish results in high-impact, peer-reviewed scientific journals and to present results at internal and external scientific meetings.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in bioinformatics, biomedical informatics, or a related field and have demonstrated hands-on experience in leading the large-scale analysis of multi-omic data. Experience with metabolomics data is strongly preferred. He or she should have demonstrated experience leveraging publicly available datasets, including their organization, cleaning and preprocessing. Applicants also should have demonstrated experience in multivariable analyses and machine/deep learning. Basic knowledge and understanding of biology and chemistry is a plus. Knowledge of R and/or Python and working within a high-performance computing/cloud environment is required.                           

The selected candidate should have excellent interpersonal, verbal and written communication skills in English and should possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. While the team is highly collaborative in nature, the pursuit of original computational research directions by the candidate is encouraged. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.                           

The review of applications will begin immediately and continue until the position is filled. Learn more about informatics research at NCATS.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Biomedical Engineer Position, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral biomedical engineering position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation. The selected candidate should have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology, fluorescence microscopy and experience working with primary cells or induced pluripotent stem cell-derived cells.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies including scRNAseq — to develop advanced cellular models for drug discovery and development. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The selected applicants will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and present work to internal and external collaborators as needed. The selected candidates also should be eligible to work in the U.S. with whomever NCATS collaborates worldwide.

Qualifications

Each applicant to this postdoctoral position should possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in areas such as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology and engineering of cells with biosensors — will be considered favorably.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for two to three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Antibody Discovery and Characterization Position, Division of Preclinical Innovation, Early Translation Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Early Translation Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to hold a postdoctoral position in antibody discovery and characterization in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment and be exposed to cutting-edge high-throughput screening, assay biology, bioinformatics, medicinal chemistry and disease-relevant biological models. They will implement antibody discovery technologies (including phage display), directed evolution, and related technologies to produce and characterize antibodies relevant to diseases and conditions related to pain, addiction and overdose, and other public health emergencies, such as the SARS-CoV-2 pandemic. The selected applicant will apply cutting-edge cell biology and bioassay technologies for the development of disease-relevant antibody selection and screening assays and will be involved in all aspects of the implementation, including assay design, assay development and optimization, antibody screening, protein engineering, data analysis and mechanism-of-action studies.

Core Responsibilities

The selected candidate should be able to work independently under team supervision. The selected applicant will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports and manuscripts and will present work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, pharmacology or a related discipline. Experience with antibody phage display technologies — including panning, ELISA, and protein purification — and an understanding of antibody domain architecture are highly desirable. The candidate should be an independent thinker, a team player, and able to work in a very interactive, fast-paced environment. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSantibody_hiring@nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.

The review of applications will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Medicinal Chemistry Position, Division of Preclinical Innovation, Therapeutic Development Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks a highly motivated synthetic chemist to serve as a postdoctoral fellow for drug discovery projects within the Therapeutic Development Branch (TDB) of its Division of Preclinical Innovation. The selected candidate will work on a multidisciplinary team to identify clinical candidates to address unmet medical needs.

Core Responsibilities

The postdoctoral fellow will be responsible for designing and synthesizing compounds for structure-activity relationship and structure-property relationship studies, developing new technologies to accelerate drug discovery, presenting results in internal and external meetings, and writing reports and manuscripts. The research will be conducted in the TDB medicinal chemistry group.

Qualifications

Applicants should have (or expect to receive) a Ph.D. in organic chemistry or medicinal chemistry at the time of joining the laboratory. The ideal candidate should be self-motivated, possess a strong work ethic, have keen attention to detail, and be able to work on multiple projects simultaneously. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary, a current curriculum vitae, and the names of and contact information for three references to Wenwei Huang, Ph.D., at huangwe@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled. 

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Genomic Toxicology Position, Division of Preclinical Innovation, Genomic Toxicology Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Genomic Toxicology Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral position and apply genomic tools to toxicology and pharmacology in the Genomic Toxicology Laboratory within the center’s Division of Preclinical Innovation (DPI). The Genomic Toxicology Laboratory, led by David L. Gerhold, Ph.D., participates in the Toxicology in the 21st Century (Tox21) program by developing methods to assess the effects of chemicals on human health, focusing on early stages of the translational process from target validation to first-in-human studies. This laboratory also develops novel human cellular 3-D and co-culture models to study cardiovascular disease, as well as neurological and renal diseases. DPI researchers collaborate closely with scientists in the 3-D Tissue Bioprinting Program, the Stem Cell Translational Laboratory, and the Therapeutics for Rare and Neglected Diseases program, as well as with other NIH institutes, centers and offices; and academic scientists. In addition to conducting cutting-edge laboratory research, DPI scientists work in a team-based environment and collaborate with more than 250 research organizations worldwide.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will complete the development and implementation of a novel high-throughput screening method that quantifies the expression of selected genes in cultured mammalian cells. The unprecedented throughput of this method will enable the screening of large chemical libraries of environmental toxicants or drug candidates. Because quantitative high-throughput screening of large chemical libraries is NCATS’ core expertise, the collaborative opportunities to apply this method to identify drug candidates and to screen Tox21 toxicant libraries are abundant. The successful applicant will work with collaborators who have developed induced Pluripotent Stem Cell (iPSC)–derived endothelial cells, as well as 3-D endothelial cell models that incorporate shear flow and co-culture with vascular smooth muscle cells. The postdoctoral candidate also will have opportunities to collaborate with scientists both within and outside of NCATS on additional projects. The selected candidate is expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals.

Qualifications

The ideal candidate will possess a doctoral degree (i.e., a Ph.D.) with a background in a relevant field of molecular or medical biology and have a strong record of high-impact publications. Applicants should possess molecular biology expertise and mammalian cell culture skills. Applicants also should possess strong oral and written English communication skills. Applicants with additional expertise in vascular biology or high-throughput screening will receive preferential consideration.

Applicants should be U.S. citizens or legal residents or should hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to David L. Gerhold, Ph.D., at NCATSGenomicTox@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Mass Spectrometry Position, Division of Preclinical Innovation, Analytical Chemistry Core Facility

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Analytical Chemistry Core Facility                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation. The selected candidate should have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.

The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.

Core Responsibilities

The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

Qualifications

The successful applicant should possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a preferred. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable.

The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary (one to two pages); a current curriculum vitae with a complete bibliography; and the names of and contact information for at least three references to Christopher A. LeClair, Ph.D., at ncats_info@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Bioengineering Positions, Division of Preclinical Innovation, 3-D Tissue Bioprinting Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
3-D Tissue Bioprinting Laboratory                           
Rockville, Maryland

Description

NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill postdoctoral bioengineering positions in the Division’s 3-D Tissue Bioprinting Laboratory. The selected candidates should have expertise in biofabrication, biomaterials or microfluidics to help establish a portfolio of functional, physiologically complex 3-D tissue models as predictive screening platforms for toxicity and efficacy drug testing. Applicants with additional expertise in microphysiological systems, immunology, neuroscience and production of induced pluripotent stem cell-derived cells will receive preferential consideration.

Core Responsibilities

The candidates will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies—including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other cutting-edge -omics technologies — to develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. They also will be expected to work independently as well-trained problem solvers in biofabrication and microfluidics, including on architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The successful candidates will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed.

Qualifications

Each applicant for this postdoctoral position should possess a Ph.D. in bioengineering, biomedical engineering, immunology, neuroscience, cell/molecular biology, pharmacology, pathology or a related discipline relevant to 3-D tissue models. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays—including work in such areas as organoids or biofabricated tissues, biomaterials, microfluidic systems, cell imaging, histology and engineering of cells with biosensors—as well as experience using bioprinting techniques, will be considered favorably. Candidates with a strong background in immunology and tissue engineering with induced pluripotent stem cell-derived cells are encouraged to apply. Applicants should be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter, a curriculum vitae with a complete bibliography, a one-page research proposal/plan for a physiologically complex 3-D tissues for disease modeling and compound testing, and the contact information for at least three references to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and continue until these positions are filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Computational Biologist/Bioinformatician, Division of Preclinical Innovation, Therapeutic Development Branch

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Therapeutic Development Branch                           
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral computational biologist/bioinformatician position in NCATS' Therapeutic Development Branch (TDB) within the Division of Preclinical Innovation.

TDB develops new systems, novel approaches and methodologies to achieve conceptual breakthroughs in preclinical therapeutics. The branch also provides collaborative access to technology and expertise in the scientific disciplines of early-discovery biology and medicinal chemistry; drug metabolism and pharmacokinetics; toxicology; and chemistry, manufacturing and controls synthesis and formulation.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will join an interdisciplinary team with a focus on profiling different cell types and responses in the context of rare genetic diseases, infectious diseases and drug treatments. He or she will be a bioinformatician/computational biologist with experience in bioinformatic analysis of NexGen sequencing datasets, with a strong emphasis in RNA-Seq analysis (bulk and single-cell). The fellow will collaborate with researchers in other universities and institutes and will learn preclinical drug development from colleagues in multidisciplinary project teams. The fellow should obtain extensive experience and skills in this training program that can be applied toward translational research for therapeutics development.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in biology, computer sciences, bioinformatics or a related discipline, with one to three years of relevant research experience. Candidates should possess strong computer programming skills in R and other required languages (e.g., Python/Perl, Java, C/C++). Experience analyzing bulk and single-cell RNA-Seq data sets is essential. The candidate also should possess strong self-motivational and problem-solving skills, as well as outstanding interpersonal and teamwork skills. Excellent analytical, organizational and time management skills are required. Experience with proteomics data sets also is preferred, but not necessary. Applicants should be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position; a current curriculum vitae with a complete bibliography; and the names of and contact information for three references to Wei Zheng, Ph.D., at NCATSTDBBioHiring@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Postdoctoral Informatics Scientist, Division of Preclinical Innovation, NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group                           
Rockville, Maryland

Description

NCATS is one of the 27 institutes and centers at NIH. The Informatics group collaborates closely with biologists and chemists to develop robust assay designs, analyze experimental outcomes and validate new hypothesis. NCATS’ informatics personnel perform a variety of ligand- and protein structure-related modeling tasks, support the drug discovery process and accelerate translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.

NCATS’ Informatics group seeks a creative, self-motivated postdoctoral informatics scientist to develop new algorithms for prediction of i) protein-ligand interactions; ii) chemical reactions and comprehensive support of drug discovery projects.

Core Responsibilities

The postdoctoral fellow will be responsible for uploading and analyzing pilot and quantitative high-throughput screening runs; analyzing assay reproducibility; analyzing confirmation and secondary screening assays; developing and applying QSAR models and molecular modeling for virtual screening of compounds; supporting medicinal chemistry efforts; and developing new algorithms for prediction of protein-ligand interactions and chemical reactions. Research will be conducted by NCATS' Informatics group.

Qualifications

The ideal candidate will possess a minimum of a Ph.D. in computational science/bioinformatics with specialization in machine learning. He or she will have published at least three research articles as first author. The successful candidate should have experience with common cheminformatics libraries and data formats (e.g., RDKit, OpenBabel, SMILES, InChi, etc.), modern software packages (e.g., MOE/CCG, OpenEye tools) and scientific programming (e.g., Python, JAVA) and data analytics (e.g., KNIME, Spotfire). He or she should be able to script work flows and implement new algorithms, have experience working with multi-disciplinary teams, and possess strong oral and written English communication skills. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras), as well as experience in developing algorithms for prediction of protein-ligand interactions and/or chemical reactions.

Applicants should be U.S. citizens or legal residents or should hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in this position, a current curriculum vitae with a complete bibliography to Alexey V. Zakharov, Ph.D., at alexey.zakharov@nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

Stem Cell Scientist and Postdoctoral Positions, Division of Preclinical Innovation, Chemical Genomics Branch, Stem Cell Translation Laboratory

National Institutes of Health                           
National Center for Advancing Translational Sciences                           
Division of Preclinical Innovation                           
Chemical Genomics Branch                           
Stem Cell Translation Laboratory                           
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from qualified candidates with expertise in developmental biology and human induced pluripotent stem cells (iPSCs) to fill stem cell scientist and postdoctoral positions in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as iPSCs, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems. Successful candidates will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS, external service providers and collaborators at top academic institutions.

Core Responsibilities

The selected candidates will join a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, compound management, automation engineering, bioinformatics, medicinal chemistry and various -omics technologies. They will work in a highly creative environment, focusing on important aspects of human pluripotency and cellular differentiation using cutting-edge technologies (e.g., single-cell analysis, deep sequencing, robotic cell culture, high-throughput electrophysiology, genome editing). They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Qualifications

Each applicant should possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Exceptional candidates with master’s degrees and strong backgrounds in stem cell biology will be considered. Candidates with experience in drug discovery, cell and tissue engineering, cell signaling, or quantitative biology are encouraged to apply. The ideal candidates should be team players with high scientific standards and have the ability to work in an interactive, fast-paced environment. They should be self-motivated to learn new technologies and be familiar with the methods and concepts of stem cell biology and regenerative medicine.

Stipends/Benefits

Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and continue until the position is filled.

Additional Information

Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).

At the discretion of the supervisor and per NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.