HHS Logo U.S. Department of Health & Human Services Divider arrow NIH logo National Institutes of Health Alt desc
Skip Over Navigation Links
Assay Development and Screening Technology

ADST Resources

ADST program experts have a documented track record of developing entry-point high-throughput screening assays as well as secondary assays using state-of-the-art tools, technologies, platforms and chemical libraries.

Assay Design Concepts and Proof-of-Concept Testing

This approach employs multimodal outputs adaptable to a variety of biological targets and pathways and can be used to construct assays that phenocopy genetically inherited diseases.

Concentration Response-Based Chemogenomic Profiling

This methodology for high-confidence primary data sets involves micro-volume (3–5 uL) concentration-response determinations of compound series or small libraries for cell-based or biochemical assays.

Collaborative Assembly of Preliminary Validation Studies

This work with high-throughput screening assays supports grant applications or other types of program needs of extramural collaborators.

Chemical/Compound Libraries

  • Approved drugs for repurposing
  • Pharmacologically active compounds for chemical genomic-based target assessment
  • Novel, high-stereogenic carbon content libraries
  • Collections of culturable pre-fractionated natural product extracts
  • Marine natural product extracts and natural product–inspired synthetic collections (e.g., chemical methodology library development) from academic collaborators
  • Molecular target–focused and pathway-annotated chemical libraries

Equipment/Tools

Detectors and reagent dispensers for a comprehensive variety of assay techniques and formats, including:

  • NCATS-developed high-throughput screening–compatible coincidence reporter systems
  • Laser scanning cytometry and automated microscopy-enabled high-content assays
  • Target-based, purified-component assays

Informatics Analysis Tools

Collaborations

  • A broad network of internal and external collaborators and expertise for early-stage translational research

Last updated: 06-08-2017
▲ Back to top