3-D Tissue Bioprinting Technical Capabilities

The 3-D Tissue Bioprinting program builds on internal expertise at NCATS in assay development for drug screening, automation technologies, stem cell biology, tissue engineering and advanced high-content microscopy.

Bioprinting Core

  • Two regenHU 3DDiscovery® bioprinters

Histology Core

  • Leica VT1200 S fully automated vibrating blade microtome
  • Leica Aperio VERSA brightfield, fluorescence and FISH digital pathology scanner
  • Leica BOND RXm fully automated advanced staining system
  • Thermo HistoStar™ embedding workstation
  • Thermo Excelsior™ AS tissue processor
  • Thermo CryoStar NX50 Cryostat
  • Thermo Gemini AS automated slide stainer
  • Thermo ClearVue™ Coverslipper

Microscopy Core

  • Fluorescence Microscopy: Nikon Eclipse Ti with a modular confocal microscope system; Nikon D-Eclipse C1; Leica TCS SP8 MP multiphoton microscope; Zeiss LSM710 with Airyscan
  • High-Content Cell Imaging Readers: Molecular Devices ImageXpress micro confocal high-content imaging system and PerkinElmer Opera Phenix high-content screening system
  • Laser Microdissection System: Leica LMD6500

Mass Spectrometry

  • Bruker rapifleX MALDI PharmaPulse
  • Agilent RapidFire high-throughput mass spectrometry system

Access to Additional High-Throughput Screening Assay Technologies

  • Hamamatsu FDSS/µCELL functional drug screening system
  • Molecular Devices FLIPR Tetra high-throughput cellular screening system
  • Meso Scale Diagnostics MESO QuickPlex SQ 120
  • Luminex FLEXMAP 3D®
  • Axion BioSystems Maestro microelectrode array system