The 3-D Tissue Bioprinting program builds on internal expertise at NCATS in assay development for drug screening, automation technologies, stem cell biology, tissue engineering and advanced high-content microscopy.
Bioprinting Core
- Two regenHU 3DDiscovery® bioprinters
Histology Core
- Leica VT1200 S fully automated vibrating blade microtome
- Leica Aperio VERSA brightfield, fluorescence and FISH digital pathology scanner
- Leica BOND RXm fully automated advanced staining system
- Thermo HistoStar™ embedding workstation
- Thermo Excelsior™ AS tissue processor
- Thermo CryoStar NX50 Cryostat
- Thermo Gemini AS automated slide stainer
- Thermo ClearVue™ Coverslipper
Microscopy Core
- Fluorescence Microscopy: Nikon Eclipse Ti with a modular confocal microscope system; Nikon D-Eclipse C1; Leica TCS SP8 MP multiphoton microscope; Zeiss LSM710 with Airyscan
- High-Content Cell Imaging Readers: Molecular Devices ImageXpress micro confocal high-content imaging system and PerkinElmer Opera Phenix high-content screening system
- Laser Microdissection System: Leica LMD6500
Mass Spectrometry
- Bruker rapifleX MALDI PharmaPulse
- Agilent RapidFire high-throughput mass spectrometry system
Access to Additional High-Throughput Screening Assay Technologies
- Hamamatsu FDSS/µCELL functional drug screening system
- Molecular Devices FLIPR Tetra high-throughput cellular screening system
- Meso Scale Diagnostics MESO QuickPlex SQ 120
- Luminex FLEXMAP 3D®
- Axion BioSystems Maestro microelectrode array system
NCATS intramural experts develop a simple, fast and automated process to make