| ID | Title | Body | Facebook Description | Facebook image | Facebook Title | Facebook Video | Twitter Description | Twitter Image | Twitter Title | Meta tags |
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| 8068 | B-Roll | Description Preview Primary screening system Arms 1 and 3 on the Primary screening system are working simultaneously on parallel processes. Microtiter plates are loaded onto the necessary devices, an operation is performed per the associated protocol and they are returned to the original storage location. Runtime: 1:36 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Acoustic compound dispense and assay detection protocols running simultaneously Multiple plates are acoustically dispensed with nanoliters of chemical compounds. Shows robotic arm 1 unloading assay and chemical compound source plates from incubator and storage hotel respectively, removing the metal lids and placing onto the acoustic dispenser. This also includes the robotic arm retrieving the plates once finished, replacing lid and loading back into storage locations. In the background arm 3 is also working to process plates for an assay detection protocol. Runtime: 9:26 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Assay detection protocol using arm 3 of Primary screening system 1536-well assay plates containing cells and chemical compounds are being loaded onto a solenoid valve low volume liquid dispenser, after the metal lid is removed, which is adding microliters of a detection reagent into every well. The lid is then put back on and the assay plate is loaded into a storage hotel for incubation. The final step in the protocol is removing the lid and loading the plate into the multimode reader to collect the resultant data. Runtime: 4:06 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Automated tissue culture robot and Arm 1 of Primary screening system In the background the automated tissue culture platform is running a process where you see the arm within going through specific steps. Simultaneously arm 1 of the Primary screening system is unloading the assay plate as well as the chemical compound acoustic source plate into their respective locations. Runtime: 2:49 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Acoustic dispense and plate unload/load Nanoliters of a library of chemical compounds are dispensed using acoustic energy into a 1536-well assay plate. Once it finishes the dispense the lifter presents the plate and the robotic arm unloads the current plate, replaces the metal lid and returns it to the incubator. The next assay plate in the queue is loaded onto the acoustic dispenser after the lid is removed by the robotic arm. Runtime: 2:11 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS End of cell splitting protocol Cells added into a new flask, returned to incubator and pipette disposed of by robotic arm. Runtime: 1:13 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Automated tissue culture robot Reagents are being dispensed and emptied from a cell flask as part of an automated cell splitting process run on the system which also includes removing and replacing the flask cap as needed and perturbing to wash flask inner surface thoroughly. Runtime: 2:39 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Plate incubator carousel rotating Assay plate incubator carousel is rotating and shows the 1536-well white microtiter plates with metal lids to prevent evaporation stored within. Runtime: 0:19 Date: 2021 Please contact NCATS to obtain the raw video footage files. Credit: NCATS Acoustic chemical compound dispense Runtime: 1:15 Date: 2021 Please contact NCATS to obtain the raw video footage files. Video courtesy of NIH's National Human Genome Research Institute. Tox21 robot b-roll B-roll of the high-speed robot screening system for the Toxicology in the 21st Century initiative. Runtime: 9:20 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=CjQTVfXQ8N4">https://www.youtub…; NCATS Chemical Genomics Center (right-to-left pan) Right-to-left pan of the front of the NCATS Early Translation Branch’s chemical genomics production line showing chemical prep area, incubator and library carousel of compounds. Runtime: 0:20 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=PTQoIGDvNLE">https://www.youtub…; Three Tox21 robots (extreme wide shot) A tilt-down wide shot showing three yellow robot arms moving plates in the testing production line. Runtime: 0:31 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=5zDnnstUHrU">https://www.youtub…; Front of production line (extreme wide angle) A wide angle establishing a shot of the front of the production line. Runtime: 0:13 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=8OuHevvKmO0">https://www.youtub…; Robots two and three working (medium shot) A medium shot of robots two and three moving plates along the production line. Runtime: 0:18 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=5DLURY1jpCo">https://www.youtub…; Two robots moving (medium shot) Medium tilt-down shot of robots one and two moving plates along the production line. Runtime: 0:26 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=PcIx_AXHL5w">https://www.youtub…; Multiple plates moving (wide shot) Wide shot, from an angle, of two robots moving plates along the production line. Runtime: 0:34 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=TzfJ2Q7HyUA">https://www.youtub…; Two robots exchanging plates (wide shot) Wide shot, from the side, showing two robots moving plate across transfer platform. Runtime: 0:19 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=r4qpw91esZE">https://www.youtub…; Transfer plate (extreme close-up) Extreme close-up of a transfer plate. Runtime: 0:14 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=xh2wEOZ9j5g">https://www.youtub…; Tilt-down feeding the detector (close-up) Close-up tilt-down shot of a robot arm placing a reaction plate on a detector that measures the reactions. Runtime: 0:23 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=8d7qjSaFwcs">https://www.youtub…; Microfluidics pipetting machine (extreme close-up to wide shot) Extreme close-up pulls back show a microfluid pipetting machine that puts chemicals in plates. Runtime: 0:18 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=kG-cAUMek7c">https://www.youtub…; Robot feeding stacking rack (wide shot with pan) Wide shot of a robot arm moving a plate to a stacking rack. Runtime: 0:09 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=Vs-ZvxEwWAI">https://www.youtub…; Control panel (wide shot) Wide shot of the control panel for the production line with a robot arm moving in the background. Runtime: 0:12 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=yAl6Nh3WxrU">https://www.youtub…; Chemistry station (wide shot) Wide shot of the chemistry station where chemicals are mixed and added to the pipeline with the robot moving in the background. Runtime: 0:16 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=yAl6Nh3WxrU">https://www.youtub…; Molecular libraries (wide shot) Static wide shot showing the molecular libraries end of the production line with a library carousel rotating. Runtime: 0:11 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=Bkj9cb7E1h4">https://www.youtub…; Two robots feed microfluidics system (medium shot) Medium shot of two robots moving plates across the transfer station in front of a fluid-handling system. Runtime: 0:12 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=msprw3faSMs">https://www.youtub…; Molecular library carousel (medium shot) Medium shot of the molecular library carousel rotating to make volumes available to production line. Runtime: 0:08 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=UstIZk2oevo">https://www.youtub…; Fluid handling (wide shot) Wide shot of the fluid supply and handling end of the production line. Runtime: 0:15 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=2oHzHua_qnw">https://www.youtub…; Technician cleaning sensor (wide shot) Medium, over-the-shoulder shot of a technician cleaning the sensor on a bench-top lab machine. Runtime: 0:07 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=aT1CZIK6JoY">https://www.youtub…; Technician cleaning plates (wide shot) Wide shot of a technician removing reaction plates from tray and cleaning them on a lab bench. Runtime: 0:20 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=sFgrMrUUXc4">https://www.youtub…; Technician laying out plates (wide shot to medium shot) Wide shot of a technician laying out plates on lab bench, with a zoom in to a medium shot as he cleans the plates. Runtime: 0:33 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=Gn9Kf23UHp0">https://www.youtub…; Technician cleaning many plates (extreme close-up) Extreme close-up of a technician cleaning reaction plates on a lab bench. Runtime: 0:10 Date: 2010 Video courtesy of NIH's National Human Genome Research Institute. YouTube embed video: <a href="https://www.youtube.com/watch?v=eB2V9TqxuDo">https://www.youtub…; | B-Roll | B-Roll | ||||||
| 8067 | Viewers & Players | File Type Name of Viewer URL of Viewer csv Microsoft Excel Viewer http://www.microsoft.com/downloads/details.aspx?familyid=1CD6ACF9-CE06-4E1C-8DCF-F33F669DBC3A (link is external) doc docx Microsoft Word Viewer http://www.microsoft.com/downloads/details.aspx?FamilyID=3657ce88-7cfa-457a-9aec-f4f827f20cac (link is external) mov Quicktime http://www.apple.com/quicktime (link is external) mp3 Microsoft Windows Media Player http://www.microsoft.com/windows/windowsmedia (link is external) mp4 Quicktime http://www.apple.com/quicktime (link is external) owl Protégé http://protege.stanford.edu (link is external) pdf Adobe Reader http://get.adobe.com/reader (link is external) ppt pptx Microsoft PowerPoint Viewer 2007 http://www.microsoft.com/downloads/details.aspx?FamilyID=048DC840-14E1-467D-8DCA-19D2A8FD7485 (link is external) swf Adobe Flash Player https://get.adobe.com/flashplayer (link is external) ttl Protégé http://protege.stanford.edu (link is external) wav wmv Microsoft Windows Media Player http://www.microsoft.com/windows/windowsmedia (link is external) wpd Microsoft Word Viewer http://www.microsoft.com/downloads/details.aspx?FamilyID=3657ce88-7cfa-457a-9aec-f4f827f20cac (link is external) xls xlsx Microsoft Excel Viewer http://www.microsoft.com/downloads/details.aspx?familyid=1CD6ACF9-CE06-4E1C-8DCF-F33F669DBC3A (link is external) zip The software needed to view these files is built-in on computers. After downloading a zip file, right-click and select "Extract files" from the menu. N/A | Viewers & Players | Viewers & Players | ||||||
| 8066 | Strategic Plan Introduction | Overview of NCATS The National Center for Advancing Translational Sciences (NCATS), one of the 27 Institutes and Centers (ICs) at the National Institutes of Health (NIH), is transforming translational science to get more treatments to more patients more quickly. NCATS relies on the power of data, new technologies and teamwork to develop, demonstrate and disseminate innovations that reduce, remove or bypass costly and time-consuming bottlenecks in translational research. Rather than targeting a particular disease or area of fundamental science, NCATS focuses on what is common across diseases and the translational process. The Center conducts and supports research on both the scientific and operational aspects of translation to lead to more predictive and successful development of new medical interventions, such as drugs, diagnostics, and medical devices, for all human diseases. NCATS’ efforts by design complement and empower those of other NIH ICs, academic scientists, the private sector and the nonprofit community. By emphasizing collaboration, innovation, deliverables and team science, the Center serves as a catalyst to enable others in the translational research ecosystem to work more effectively. Translation and Translational Science Defining Translation and Translational Science Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes. Translational science is the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process. NCATS studies translation on a system-wide level as a scientific and operational problem. Translational Science Spectrum The translational science spectrum, as illustrated in the graphic above, represents each stage of research along the path from the biological and chemical basis of health and disease to interventions that improve the health of individuals and the public. The spectrum is not linear or unidirectional; each phase builds upon and informs the others. At all stages of the spectrum, NCATS develops new approaches, demonstrates their usefulness, and disseminates the findings. Patient involvement is a critical feature of all phases in translation. Basic Research — Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research. Preclinical Research — Preclinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing of medical interventions is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems. Clinical Research — Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention. Clinical Implementation — The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care. Public Health — In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones. Center Organization NCATS’ divisions and offices span the entire spectrum of translational science. Through programs in its Division of Preclinical Innovation, the Center drives advances in early stages of the translational process, from target validation to first-in-human studies. Through its Division of Clinical Innovation, NCATS supports clinical and translational research, creating and sharing the expertise, tools and training needed to develop and deploy effective treatments in people. Cross-cutting programs in rare diseases, translational technologies, strategic alliances and other emerging areas address scientific and operational barriers to enable faster and more effective interventions that tangibly improve human health. Bridging the Gap: Scientific and Operational Challenges and Opportunities in Translational Science Several thousand genetic diseases affect humans, of which only about 500 have any treatment. A novel drug, device or other intervention can take about 14 years and cost $1 billion or more to develop, and about 95 percent never make it past clinical trials. Even when a new drug or other intervention is developed and shown to be effective in clinical trials, many years may pass before all patients who could benefit from it are identified and treated. Numerous scientific and organizational roadblocks can limit the speed of progress. Obstacles along the path to translation include: Lack of understanding about the science of translation and insufficient rigor in conducting translational research, leading to unpredictability and frequent failure of possible interventions A shortage of qualified translational investigators Organizational structures and incentives that do not encourage the teamwork essential to translational science Inflexible and inefficient clinical trial implementation and low participation in studies A lack of data interoperability Insufficient tools and technologies to predict toxicology and efficacy in safety assessment A shortage of qualified biomarkers for application in disease diagnosis and measurement of treatment response Inadequate development and measurement of appropriate clinical outcome measures or endpoints, including patient reported outcomes | /sites/default/files/Spectrum_Graphic_900px.jpg | Strategic Plan Introduction | By emphasizing collaboration, innovation, deliverables and team science, NCATS serves as a catalyst to enable others in the translational research ecosystem to work more effectively. | /sites/default/files/Spectrum_Graphic_900px.jpg | Strategic Plan Introduction | |||
| 8065 | NCATS Strategic Principles | NCATS’ strategic principles represent its philosophy. To accomplish the overarching goal of bringing more treatments to more patients more quickly, NCATS programs are guided by the following principles: Catalytic: NCATS is a catalyst that enables others to perform more efficient and effective translation. Generalizable Principles: NCATS uncovers fundamental principles shared among diseases and translational processes; widespread implementation of such generalizable principles will accelerate translation. Innovative: NCATS programs lead to profound improvements in translational understanding and effectiveness, producing innovation that establishes fundamentally new ways of doing translation that are multiplicative in their effects. Collaborative: Translational research endeavors require the expertise of multiple people and groups, particularly as the research is carried across through different phases of the translational science spectrum. NCATS approaches translation as a “team sport.” Patient-focused: At all phases of translational science, NCATS is committed to patients and their communities and looks for opportunities to include the patient perspective. The ultimate goal of translation is tangible improvement in health, so the perspectives of and partnerships with patients are crucial. Measurable: NCATS continuously improves translational effectiveness, so programs must be designed and implemented with explicit indicators of success for translational progress. | To accomplish the overarching goal of bringing more treatments to more patients more quickly, NCATS programs are guided by these principles. | /sites/default/files/strategic-plan_900px.jpg | NCATS Strategic Principles | To accomplish the overarching goal of bringing more treatments to more patients more quickly, NCATS programs are guided by these principles. | /sites/default/files/strategic-plan_900px.jpg | NCATS Strategic Principles | ||
| 8064 | Strategic Plan Development | Internal Process: Strategic Principles NCATS employees were engaged in the early stages of the Center’s strategic planning process to provide their perspectives on the fundamental characteristics that guide activities at NCATS, both current and aspirational. Through a series of small group discussion sessions, the opinions and insights of nearly all NCATS employees were gathered. These diverse perspectives contributed to the development of the request for external input as well as the final strategic principles that are presented in the NCATS Strategic Principles section. Gathering External Input: Focus Groups To identify the key strategic planning topics on which NCATS would seek public input, NCATS created a series of focus groups composed of NCATS researchers, program leaders, other staff, and members of NCATS’ two advisory committees: the Advisory Council and the Cures Acceleration Network (CAN) Review Board. Each focus group was asked to identify priorities and challenges in each of six pre-defined overarching areas of NCATS’ research and operational activities. These focus areas were: Preclinical Innovation — Improving the Drug Development Process; Preclinical Innovation — Testing and Predictive Models; Repurposing Drugs; Re-Engineering the Clinical and Translational Process; Accelerating and Supporting Rare Diseases Research; and Building Partnerships with Stakeholder Groups. All focus groups also were asked to consider two cross-cutting questions: (1) how NCATS could more effectively engage with patients and community members in each phase of translation, and (2) how the strategic plan should address the role of “big data” and informatics in translational science. Stakeholder Engagement: RFI and Webinars After receiving additional input from NCATS Advisory Council and CAN Review Board members at a public meeting in early September 2015, NCATS launched the stakeholder engagement phase of the strategic planning process in October 2015 to solicit feedback from the broader public. The goal of this phase was to identify areas of opportunity, challenges and research needs in translational science to help set the Center’s strategic priorities. NCATS’ stakeholders include, but are not limited to, patients and members of the health advocacy community; basic, translational and clinical scientists at universities and research institutions; health care providers; biotechnology, venture capital and pharmaceutical industry members; colleagues at other NIH Institutes, Centers and Offices; partners at other government agencies (e.g., the Food and Drug Administration and other Department of Health and Human Services agencies, the Environmental Protection Agency, and the Department of Defense); policymakers; and the general public. A public request for information (RFI) and a series of four “town hall” webinars were the principal vehicles used to solicit feedback from these individuals and groups. The RFI was publicly disseminated in October 2015 and was open for comment until February 2016, and the public informational webinars took place in October and November 2015. Through the RFI, NCATS encouraged stakeholders to comment on any issues of interest that apply across the translational science spectrum, including: Breaking down professional, cultural and scientific silos across the translational science spectrum Focusing on inter-operability of data systems (such as integrating patient data and electronic health records into preclinical research) Expanding research efforts at NCATS into new therapeutic modalities Focusing on patient-driven research and patient/community engagement Forming innovative partnerships with a wide variety of stakeholders Identifying skillsets and competencies needed for training the next generation of translational scientists Using modern communication and dissemination tools to expand awareness of translational science to a wide variety of stakeholders NCATS received 54 responses to the RFI from individuals, organizations and institutions representing academia, government, industry, patient advocates, and health care providers. A total of 119 unique participants from around the country and across multiple sectors signed into the webinars to learn more about the NCATS strategic planning process and how best to contribute comments about the Center’s strategic priorities via the RFI. The analysis of RFI responses involved carefully reviewing each response, along with any attached supplementary materials, and identifying specific recommendations and actionable items provided. The responses addressed a broad array of priority issues across both the scientific and operational domains of translation, and directly informed the development of the objectives and example approaches within each strategic goal. | NCATS developed its Strategic Plan by creating strategic principles and engaging focus groups and stakeholders. | /sites/default/files/strategic-plan_900px.jpg | Strategic Plan Development | NCATS developed its Strategic Plan by creating strategic principles and engaging focus groups and stakeholders. | /sites/default/files/strategic-plan_900px.jpg | Strategic Plan Development | ||
| 8063 | Structure of the Strategic Plan | The Strategic Plan is organized into four overarching themes of translational science, collaboration and partnerships, education and training, and stewardship. Each theme is captured within a strategic goal, and collectively, they provide an overview of what NCATS plans to accomplish to achieve its mission. The objectives listed under each Strategic Goal offer greater context to the high-level themes and will be used to guide NCATS in developing, evaluating and refining its research and operational agenda over time. Example approaches are potential ways for NCATS to achieve these objectives. In brief, the strategic goals reflect NCATS’ overarching mission, the objectives provide context for each goal, and the example approaches offer more specific tactics for undertaking the objectives. | The Strategic Plan is organized into four overarching themes of translational science, collaboration and partnerships, education and training, and stewardship. | /sites/default/files/strategic-plan_900px.jpg | Structure of the Strategic Plan | The Strategic Plan is organized into four overarching themes of translational science, collaboration and partnerships, education and training, and stewardship. | /sites/default/files/strategic-plan_900px.jpg | Structure of the Strategic Plan | ||
| 8062 | Strategic Plan Acknowledgments | NCATS appreciates the extensive input from its staff, the NCATS Advisory Council, the Cures Acceleration Network Review Board, and members of the translational science community in the development of this strategic plan. In particular, NCATS would like to thank the members of the Strategic Plan Working Group for leading the development of this plan: Penny Burgoon, Christine Cutillo, C. Taylor Gilliland, Cindy McConnell and Dorit Zuk. | NCATS appreciates the extensive input from many members of the community in the development of this Strategic Plan. | /sites/default/files/strategic-plan_900px.jpg | Strategic Plan Acknowledgments | NCATS appreciates the extensive input from many members of the community in the development of this Strategic Plan. | /sites/default/files/strategic-plan_900px.jpg | Strategic Plan Acknowledgments | ||
| 8061 | Megan O'Boyle (2019) | Ms. O’Boyle is the Principal Investigator for the PCORI funded Phelan-McDermid Syndrome (PMS) Data Network (PMS_DN, PCORnet) and the Phelan-McDermid Syndrome International Registry (PMSIR). She is also a parent of a child with Phelan-McDermid Syndrome. This diagnosis includes autism, intellectual disabilities, epilepsy, ADHD, and other medical conditions. The web-based PMSIR was launched in May 2011, and currently has more than 70% of the PMS Foundation families enrolled. Ms. O’Boyle also directed a biosample collection for PMS families that is now part of the NIMH Stem Cell Center at the Rutgers University Cell and DNA Repository. She is passionate about the value of the patient’s voice in research, drug development, clinical trial design, development of related legislation, and quality of life decisions. She advocates for data sharing, developing international patient registries, improving patient engagement, sharing resources and streamlining IRB practices and policies. | Ms. O’Boyle is the Principal Investigator for the PCORI funded Phelan-McDermid Syndrome (PMS) Data Network (PMS_DN, PCORnet) and the Phelan-McDermid Syndrome International Registry (PMSIR). | Megan O’Boyle | Ms. O’Boyle is the Principal Investigator for the PCORI funded Phelan-McDermid Syndrome (PMS) Data Network (PMS_DN, PCORnet) and the Phelan-McDermid Syndrome International Registry (PMSIR). | Megan O’Boyle | ||||
| 8060 | Daniel Hartman (2019) | Daniel L. Hartman, M.D., joined the Bill & Melinda Gates Foundation in 2012 as the director of Integrated Development and leads a team that provides technical expertise in drug and diagnostic development. Under his leadership, Integrated Development works closely with the Foundation’s strategy teams to manage product pipelines through clinical trials and to provide help with manufacturing, compliance and regulatory strategy/intelligence. Hartman joined the Foundation after four years as president and chief executive officer of Great Lakes Development, Inc., a consulting company that provides strategic and operational support for early drug development projects. Previously, Hartman served as senior vice president of product development at deCODE genetics, executive director of Pfizer Global Research and Development and vice president of Global Clinical Development at Esperion Therapeutics. He also has held senior clinical research positions at Eli Lilly & Company and is a member of the Scientific Medical Advisory Board at Hopen Life Science Ventures. Hartman received his bachelor’s degree from Calvin College and his medical degree from Wayne State University. He trained in internal medicine and completed a fellowship in pulmonary medicine at Indiana University, where he was chief medical resident. | Dr. Dan Hartman joined the Bill and Melinda Gates Foundation in 2012 as the Director of Integrated Development and leads a team that provides technical expertise in drug and diagnostic development. | Daniel Hartman | Dr. Dan Hartman joined the Bill and Melinda Gates Foundation in 2012 as the Director of Integrated Development and leads a team that provides technical expertise in drug and diagnostic development. | Daniel Hartman | ||||
| 8059 | Alan Palkowitz (2019) | Alan Palkowitz, Ph.D., is currently senior research professor of medicine in the Department of Clinical Pharmacology at the Indiana University (IU) School of Medicine. He is a key contributor to multiple translational programs focusing on Alzheimer’s disease and pediatric cancers as part of the IU Precision Health Initiative. Palkowitz most recently was the vice president of discovery chemistry research and technologies at Eli Lilly and Company, where he worked for 28 years. In his role as vice president, Palkowitz was responsible for the global small-molecule strategy and delivery of clinical candidates in all areas of disease focus, including cancer, diabetes, immunology, pain and neurodegenerative disorders. Palkowitz oversaw a large, multisite global research enterprise that included medicinal chemistry, computational and biophysical/structural sciences, molecular and cellular pharmacology, analytical technologies, synthetic technologies, and automation sciences. Palkowitz championed the creation of multiple molecular discovery strategies to diversify approaches to drug discovery and successfully expand therapeutic innovation. In addition, he designed and implemented unique business models aimed at expanding global access to diverse talent and capabilities in partnership with academic centers, small biotech companies and government researchers. As a member of the Lilly Research Laboratories leadership team, Palkowitz participated in setting strategic direction for the company, along with technical governance of the discovery and early clinical development pipeline. He currently serves on several advisory groups, including the NCATS Advisory Council and the National Academy of Sciences Board on Chemical Sciences and Technologies. | Dr. Palkowitz is the Vice President of Discovery Chemistry Research and Technologies at Eli Lilly and Company. | Alan Palkowitz | Dr. Palkowitz is the Vice President of Discovery Chemistry Research and Technologies at Eli Lilly and Company. | Alan Palkowitz |
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