Targeted Genome Editor Delivery (TARGETED) Phase 2 Challenge Winners
In Phase 2, participants submitted data from studies that demonstrated delivery and editing performance as well as described their methodology, technology, and how their solution addressed the Challenge criteria. Only Phase 2 winners are eligible to participate in Phase 3.
See more details about the Challenge
View the Phase 1 Winners
Winners of Phase 2
Target Area 1: Programmable Delivery System for Gene Editing
Winning Solutions $250,000 Prize
Exosome Engineers (University of Nebraska-Lincoln)
"Editing the Genome in Any Tissue of Choice Through Programmable Milk Exosomes"
Perelman School of Medicine at the University of Pennsylvania
"Targeted Delivery of Genome Editing Machinery to Lungs, Systemic Endothelium and Muscles"
David R. Liu Group, Broad Institute of MIT and Harvard
"Tissue-Specific Targeted eVLPs Through Barcoded Lentiviral Screening and Rational Engineering"
Beth Israel Deaconess Medical Center and University of Washington
"ENTER: Elastin-based Nanoparticles for Therapeutic delivERy, Self-Assembled Protein Nanoparticles for Targeted Gene Editor Delivery"
Ben Deverman Vector Engineering Laboratory, Broad Institute of MIT and Harvard
"Engineering Receptor-Targeted AAVs with Predictable Cellular and Species Tropism"
Winning Solutions $50,000 Prize
Columbia-Leong Oral Editing
"Oral Nonviral Gene Editing System"
Helex, Inc.
"Programmable Lipid Nanoparticles for Targeted Genome Editing for Extra-Hepatic Targets"
Medical College of Wisconsin and Università degli Studi di Milano (University of Milan)
"One System, Any Target"
ProEdit (University of Washington)
"ProEdit: Programmable Genome Editing to Target Diverse Organ and Cell Lineages"
Smart Gene Darts (SGD) (Case Western Reserve University)
"Smart Programmable Lipid Nanoparticle Platform for Gene Editing"
Target Area 2: Crossing the Blood Brain Barrier
Winning Solutions $250,000 Prize
Crisaptics Trans-BBB Genome Editing Team (University of Maryland School of Medicine)
"Crisaptics Trans-BBB"
PERCEPT (Innovative Genomics Institute at UC Berkeley)
"Chemically Engineered CRISPR Enzymes for Accessible Whole-Brain Genome Editing"
Icahn School of Medicine at Mount Sinai
"Blood-Brain Barrier-Crossing Lipid Nanoparticles for Genome Editing"
STEP Team (Yale University)
"BRAIN TARGETED-STEP RNPs for Delivery of Genome Editing to the Brain"
See more information about Phase 3 of the TARGETED Challenge