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Funding Opportunities

We offer an array of funding opportunities that support our mission of turning research observations into health solutions through translational science.

Open Funding Opportunities

Find an open funding opportunity using the search tool. The expiration date currently displayed is the final expiration date.

Learn more about the NIH clinical trial requirements for grants and contracts.

If you are looking for closed opportunities, visit grants.nih.gov.

Investigators may apply for NIH-funded scientific conference grants to support high-quality national and international meetings that are relevant to public health and our mission. See NIH’s frequently asked questions for more information.

Name NCATS Issued FOA Number Activity Code Posting Date Expiration Date Opportunity Type
Notice of Extension for RFA-TR-25-002 Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed) NOT-TR-26-009 06/05/2026 Notice of Change to Funding Opportunity
Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed) PAR-25-450 R21 09/22/2025 07/20/2028 NA
Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional) PAR-25-438 U54 06/06/2025 10/16/2025 NA
Notice of Intent to Publish the re-issuance of the Notice of Funding Opportunity (NOFO) Rare Diseases Clinical Research Consortia (RDCRC) for the Rare... NOT-TR-25-008 05/05/2025 Notice of Information
Notice of Announcement of the NCATS Rare Diseases Are Not Rare! 2025 Challenge Prize Competition NOT-TR-25-014 07/30/2025 Notice of Information
Notice of Rare Diseases Clinical Research Network Alumni Site: Data Storage and Access NOT-TR-25-012 07/21/2025 Notice of Information
Notice of Change to Application Due Dates for PAR-25-438, "Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research N... NOT-TR-25-010 06/17/2025 Notice of Change to Funding Opportunity
Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed) RFA-TR-25-002 R21 12/06/2024 06/02/2027 NA
NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional) RFA-HL-26-015 R44 11/18/2024 11/16/2025 NA
Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) PAR-25-122 R03 10/28/2024 11/16/2027 NA
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Last updated on June 12, 2026