NIH HEAL Funding, Prize & Collaboration Information

As part of the NIH HEAL (Helping to End Addiction Long-termSM) Initiative, NCATS supports and facilitates a variety of funding, prize and collaboration opportunities designed to address the opioid crisis, including pain management.

Two scientists at a computer

(Daniel Soñé Photography)

Current Funding Opportunities

  • RFA-TR-19-005: HEAL Initiative: Biofabricated 3D Tissue Models of Nociception, Opioid Use Disorder and Overdose for Drug Screening (UH2/UH3 Clinical Trial Not Allowed)
  • RFA-TR-19-003: HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed)
  • RFA-NS-19-021: HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
    • NOT-NS-19-028: Notice of Change to Key Dates for RFA-NS-19-021 "HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)"
  • NOT-TR-19-009: Notice of Correction to Revise Application Due Dates for NOT-TR-19-001 Notice of Availability of Administrative Supplements for Microphysiological Systems Developers: Development of Tissue Chips to Model Nociception, Opioid Addiction and Overdose

Current Prize Challenges

  • NOT-TR-18-031: HEAL Initiative: Announcement of the NCATS ASPIRE Design Challenges to Develop Innovative and Catalytic Approaches Towards Solving the Opioid Crisis

Translational Research Collaboration Opportunities

Additional Funding Collaborations Involving NCATS

Clinical Trials and Implementation

  • RFA-AT-19-004: HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3 Clinical Trial Optional)
  • RFA-NS-19-010: Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed)
  • NOT-NS-19-014: HEAL Initiative: Notice of Interest in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at Enhanced Pain Management and Improved Treatments for Opioid Misuse and Addiction
  • RFA-DA-19-019: HEAL Initiative: America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis (R43/R44 - Clinical Trial Optional)
  • RFA-DA-19-020: HEAL Initiative: America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis (R41/R42 - Clinical Trial Optional)
  • RFA-NS-19-020: HEAL Initiative: Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (U44 Clinical Trial Not Allowed)

Devices to Treat Pain

  • RFA-EB-18-003: HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)
  • RFA-NS-19-016: HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)
  • RFA-NS-19-017: HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)
  • RFA-NS-19-018: HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)
  • RFA-RM-19-001: HEAL Initiative: Stimulating Peripheral Activity to Relieve Conditions (SPARC): Anatomical and Functional Mapping of Pain-Related Visceral Organ Neural Circuitry (U01 Clinical Trial Optional)