Job Opportunities

NCATS is looking for innovative partners to join its dynamic team. Learn more about current job opportunities at NCATS or across NIH and the U.S. Department of Health and Human Services (HHS). NIH and HHS are Equal Opportunity Employers.

All information provided by candidates will remain confidential and will not be released outside the NCATS search process without a signed release from candidates. NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. DHHS and NIH are Equal Opportunity Employers. NIH is dedicated to building a diverse community in its training and employment programs.

Current Vacancies

Postdoctoral Positions in the Division of Preclinical Innovation

Bioinformatician, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a bioinformatician position in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the Center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as induced pluripotent stem cells, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems.

The successful candidate will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS and collaborators at top academic institutions.

Core Responsibilities

Computational analysis is integral to the laboratory’s efforts in the deep characterization of stem cell states and functional cell types from different developmental lineages. The bioinformatician will be required to promptly turn around analysis results to respond to biologists’ ongoing projects, work on multiple projects in parallel, and coordinate and oversee data analysis with external service providers.

Qualifications

Applicants should have a master’s degree or higher in bioinformatics, computational biology or biomedical data science. The ideal candidate should have strong science communication skills; clear and effective data visualization skills; the ability to work well independently and in a team environment; creative problem-solving skills; and a proven ability to apply the cutting-edge, rigorous standards of the bioinformatics fields. Applicants should possess a solid knowledge of R statistical programming language; familiarity with the handling, management and storage of large-scale sequencing data; and experience querying public databases, including the SRA, GEO and dbGaP.

Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms (e.g., bulk and single-cell RNA-Seq; ChIP-seq methods, such as MeDIP-seq; bulk and single-cell ATAC-seq; and miRNA-seq). Experience with other ‑omics — such as WES, WGS and targeted sequencing methods — are a plus. The ideal candidate will have experience with pre-processing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, HTSeq, featureCounts, salmon, GATK) and R packages designed for the above-mentioned methods (e.g., DESeq2, limma, Seurat). A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of NIH’s high-performance computing capabilities, are preferred.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae and complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Branch Chief and Associate Director for Clinical Affairs, Division of Clinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Clinical Innovation
Bethesda, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional candidates with recognized leadership and demonstrated innovation and expertise in current clinical research, clinical trials, translational science, regulatory compliance, quality improvements epidemiology and public health research to serve as the branch chief and associate director for clinical affairs in its Division of Clinical Innovation (DCI).

Core Responsibilities

The branch chief and associate director for DCI clinical affairs is responsible for the overall stewardship of all medically related activities under the NCATS Clinical and Translational Awards Program (CTSA) Program, which includes the Trial Innovation Network and related CTSA clinical research and clinical resources.

Qualifications

The ideal candidate will possess a record of accomplishment in innovation in clinical and translational processes and an outstanding record of scientific accomplishment in public and/or private sector research. Each applicant must possess an M.D. or an equivalent degree, as well as senior-level experience, leadership and accomplishment in one or more medical and/or scientific disciplines of translational science, from target validation through health care utilization research. Experience in running large, complex, multidisciplinary and dynamic programs is desired, with particular strength in human-subjects research, regulatory science and policy.

Candidates should demonstrate a clear pattern of success in setting, planning, implementing and analyzing research project or program objectives and priorities; the ability to manage financial and human resources in leading research projects or programs involving extensive internal and external collaboration; the ability to communicate effectively with diverse scientific and lay audiences; and the ability to form collaborations with national and international organizations, as well as with individuals who represent wide-ranging disciplines and competing priorities.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments; a full civil service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available.

How to Apply

Interested individuals should apply via USAJobs.gov Supervisory Physician announcement number NIH-GR-DH-21-11036792 from March 1 to March 10, 2021, for Montgomery County, Maryland. The announcement includes additional information regarding medical and scientific specialties, qualification requirements, evaluation criteria and application instructions.

Please direct questions about applying to Heather Powell at 301-827-3982 or powellhm@mail.nih.gov.

Data Scientist, Division of Preclinical Innovation – Informatics Core

NCATS seeks a data scientist to play an integral role in evaluating thousands of rare diseases to elucidate new knowledge in a currently untapped industry. The scholar’s work will serve to further the research understanding of more than 7,000 rare diseases for which existing data is currently ripe for integration and use.

The scholar will have support from expert NCATS staff who will help translate the scholar’s work into actionable and scalable solutions. This work will support NCATS’ mission of bringing more treatments to more patients more quickly.

View the Vacancy AnnouncementApply by April 9, 2021

Senior Clinical Advisor, Division of Clinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Clinical Innovation
Bethesda, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional candidates with recognized leadership and demonstrated innovation and expertise in current clinical research, clinical trials, translational science, regulatory compliance, quality improvements, epidemiology and public health research to serve as the senior clinical advisor in its Division of Clinical Innovation (DCI).

Core Responsibilities

The senior clinical advisor is responsible for representing DCI and NCATS in clinically related programs across NIH, with other government agencies, industry, academia and patient-support organizations, as well as advising the DCI director on related matters.

Qualifications

The ideal candidate will possess a record of accomplishment in innovation in clinical and translational processes and an outstanding record of scientific accomplishment in public and/or private sector research. Each applicant must possess an M.D. or an equivalent degree, as well as senior-level experience, leadership and accomplishment in one or more medical and/or scientific disciplines of translational science, from target validation through health care utilization research. Experience running large, complex, multidisciplinary and dynamic programs is desired, with particular strength in human-subjects research, regulatory science and policy.

Candidates should demonstrate a clear pattern of success in setting, planning, implementing and analyzing research project or program objectives and priorities; the ability to manage financial and human resources in leading research projects or programs involving extensive internal and external collaboration; the ability to communicate effectively with diverse scientific and lay audiences; and the ability to form collaborations with national and international organizations, as well as with individuals who represent wide-ranging disciplines and competing priorities.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments; a full civil service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available.

How to Apply

Interested individuals should apply via USAJobs.gov Physician (Research) announcement number NIH-GR-DH-21-111036788 from March 1 to March 10, 2021, for Montgomery County, Maryland. The announcement includes additional information regarding medical and scientific specialties, qualification requirements, evaluation criteria and application instructions.

Please direct questions about applying to Heather Powell at 301-827-3982 or powellhm@mail.nih.gov.

Staff Scientists (Biologists), Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Rockville, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional scientists to serve as biologists in the Division of Preclinical Innovation (DPI). DPI studies the translation of basic discoveries into tangible improvements to human health at a systems level as a scientific and operational problem. The scientists within DPI come from a broad range of scientific disciplines—including therapeutic discovery, preclinical development, toxicology, biomarkers and clinical application—to reduce, remove or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce.

Core Responsibilities

The selected candidates will contribute to the strategic vision, implementing the science and mentoring trainees. They also must be able to interact with outside collaborators and make substantial contributions to the science. The selected candidates will collaborate with other scientists both within and outside of NCATS on such initiatives as the Center’s response to the COVID-19 pandemic.

Qualifications

Each applicant must hold a doctoral degree (M.D., Ph.D. or equivalent) in a relevant field and be a recognized expert and accomplished leader in the field. Applicants must possess a broad range of biology experience that includes at least some of the following: cell biology; biophysical characterization of small-molecule interactions with protein targets; assay design; methods to measure drugs and metabolites in biological samples; high-throughput screening; antiparasitic drug discovery, including antivirals and antimalarials; biochemistry; and genetics. The candidates should have proven experience analyzing the molecular commonalities across a broad range of diseases that could be exploited for therapeutic development.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments; a full civil service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available.

How to Apply

Please submit a cover letter describing your interest in the position, including a career synopsis (1–3 pages); a current curriculum vitae and complete bibliography; and the names of and contact information for three references to NCATSSSRecruit@mail.nih.gov.

The position will remain open from Dec. 14, 2020 to April 30, 2021. Learn more about intramural research at NCATS.

Staff Scientists (Chemists), Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Rockville, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional scientists to serve as chemists in the Division of Preclinical Innovation (DPI). DPI studies the translation of basic discoveries into tangible improvements to human health at a systems level as a scientific and operational problem. The scientists within DPI come from a broad range of scientific disciplines—including therapeutic discovery, preclinical development, toxicology, biomarkers and clinical application—to reduce, remove or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce.

Core Responsibilities

The selected candidates will oversee the research conducted by staff and trainees, provide training on specialized equipment and interpret data. Selected candidates will collaborate with other scientists both within and outside of NCATS on such initiatives as the Helping End Addiction Long-termSM initiative, or NIH HEAL InitiativeSM, and the Center’s response to the COVID-19 pandemic.

Qualifications

Each applicant must hold a doctoral degree (M.D., Ph.D. or equivalent) in a relevant field and be a recognized expert and accomplished leader in the field. Applicants must possess strong medicinal chemistry expertise, including demonstrated experience with process chemistry and scale-up operations and expertise with synthetic and analytical chemistry approaches typically applied to small-molecule probes and to determine the purity of synthesized compounds. Candidates may use nuclear magnetic resonance, high-resolution mass spectrometry or other state-of-the-art equipment to analyze the purity of compounds and verify chemical structures.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments; a full civil service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available.

How to Apply

Please submit a cover letter describing your interest in the position, including a career synopsis (1–3 pages); a current curriculum vitae and complete bibliography; and the names of and contact information for three references to NCATSSSRecruit@mail.nih.gov.

The position will remain open from Dec. 14, 2020 to April 30, 2021. Learn more about intramural research at NCATS .

Postdoctoral Positions in the Division of Preclinical Innovation

The Division of Preclinical Innovation (DPI) is the intramural (i.e., on-site) research program of NCATS and is located in Rockville, Maryland, a few miles from the main NIH campus in Bethesda, Maryland. DPI focuses on early stages of the translational process, from target validation to first-in-human studies. More than 200 scientists from a variety of disciplines and across the spectrum from early-career scientists to senior leaders are responsible for advancing the diverse research portfolio of DPI. In addition to conducting cutting-edge laboratory research, DPI scientists collaborate with more than 250 research organizations worldwide.

DPI scientists work in a collaborative, team-based environment. The postdoctoral candidate will be recruited to work on the specific projects described below and will have ample opportunities to collaborate with scientists both within and outside of NCATS on additional projects. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Postdoctoral fellows also gain additional professional skills and exposure to a variety of career paths through participation in the DPI training program.

Postdoctoral Fellow in Clinical and Biomedical Informatics, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
DPI Informatics Core
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellowship position in the DPI Informatics Core within the Center’s Division of Preclinical Innovation. Applicants to this intramural program should have a background in clinical informatics with an interest in data science. The Informatics Core is a dynamic, interdisciplinary team of clinical, bio- and chem-informaticians, translational researchers, and project managers interested in evaluating drug–disease relationships. For these assessments, the team uses knowledge sources containing clinical, -omic and in vitro assay data (e.g., high-throughput screening) that are curated and/or supported and managed at NCATS. Relevant knowledge sources include but are not limited to the Genetic and Rare Diseases Information Center (GARD), Pharos and Inxight. The goal is to bridge preclinical and clinical assessments to find new putative targets.

Candidates with a solid understanding in database management, integration of multiple data sources, data cleaning/processing/harmonization, interoperability and machine learning are preferred. Experience with various types of data sets as listed above is preferred. Although the team is highly collaborative in nature, the candidate’s pursuit of original research directions is strongly encouraged.

Core Responsibilities

The successful candidate will collect, analyze and curate data from clinical trials, U.S. Food and Drug Administration (FDA) drug labels and FDA orphan designations to elucidate the therapeutic development landscape of diseases, including rare diseases. He or she will identify relevant associations of clinical and molecular factors (e.g., genetic, -omics, etc.) and disease, including rare outcomes and response to treatments. Patient data will be accessed through various electronic health records systems, resources and programs available at NIH (e.g., Biomedical Translational Research Information System, NIH Clinical Center, Clinical and Translational Science Awards [CTSA] Program Data to Health Coordination Center [CD2H], National COVID Cohort Collaborative [N3C] and the Biomedical Data Translator program). The successful candidate then will develop new and robust code to automate the use — and augment data resources — of existing knowledge warehouses, including those developed within NCATS, and contribute to efforts for standardizing and developing new ontologies (e.g., GARD ontology, etc.). He or she is expected to use state-of-the-art linear and nonlinear multivariable modeling and machine learning to identify aforementioned relevant associations and to support clinical decision-making. The candidate will work closely with bioinformaticians, scientists and clinicians to interpret findings and identify areas that require further investigation (e.g., screening or molecular profiling). He or she will present results to the team and to the wider scientific community, draft manuscripts and publish results in peer-reviewed journals, and develop and implement novel approaches when standard approaches are not sufficient.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in clinical informatics, biomedical informatics, bioinformatics, or a related field and have demonstrated hands-on experience in leading the analysis of a large (multiple hundreds or greater) cohort data set. He or she should have demonstrated experience in organizing, cleaning and harmonizing large data sets, as well as in applying robust statistical methods, including multivariable analyses, machine learning, etc. Knowledge of R and/or Python is required, and basic knowledge and understanding of clinical and biological interpretation of molecular data (e.g., -omics, assay screening data, etc.) is preferred.

The selected candidate must have excellent interpersonal, verbal and written communication skills in English and must possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. Applicants must be eligible to work in the United States for any employer.

Stipends

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale. The position is renewable for up to five years.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (1–2 pages), a current curriculum vitae with complete bibliography, and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Fellow, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Therapeutic Development Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellowship position in the intramural laboratories of the Therapeutic Development Branch (TDB) within the Center’s Division of Preclinical Innovation. NCATS routinely partners with external collaborators from universities, pharmaceutical and biotechnology companies, and disease research foundations to form multidisciplinary project teams with expertise in assay development, high-throughput screening (HTS), bioinformatics analysis, medicinal chemistry, disease-relevant biological models and preclinical drug development. As such, the TDB biology group is looking for a self-motivated postdoctoral fellow to work in a highly creative and collaborative team environment to advance drug discovery and drug development projects. Research conducted by members of the TDB biology group has a broad focus and spans multiple disease areas, including genetic diseases (e.g., lysosomal storage disorders, neuronal diseases, cancer and infectious diseases).

Core Responsibilities

The fellow will develop in vitro biochemical and cell-based assays for HTS of compound libraries to identify lead compounds, which will be used as tools to further understand disease pathophysiology and to be developed as therapeutics. He or she will learn and participate in the drug discovery/development process and will apply new technologies — including patient induced pluripotent stem cell (iPSC)-based disease models and high-content phenotypic profiling — using cell-based imaging assays for evaluating drug efficacy and toxicity. Interrogation of drug mechanisms of action and proof-of-concept studies also will be undertaken. The fellow will collaborate with researchers in other universities and NIH Institutes and Centers and present experimental findings at scientific conferences. Upon completion of training, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities.

The fellow will communicate results to project team members and collaborators and provide updates to senior management. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and the raw data are properly retained. The fellow also will write technical reports, manuscripts and patent applications.

Qualifications

The ideal candidate will possess a doctoral degree (i.e., a Ph.D.) with a background in biology, molecular biology or pharmacology and have a strong record of high-impact publications. Experience in stem cell research (especially iPSC-derived cells) or drug screening is helpful, however, training can be provided at NCATS in these areas. Candidates should be independent thinkers and team players who are able to work in an interactive and high-paced environment.

The incumbent is required to possess excellent interpersonal skills, including the ability to clearly and succinctly communicate in a timely manner and a proven ability to foster important relationships with Division colleagues and external collaborators. He or she must maintain the integrity and accuracy of project information to meet project requirements and use project management software, such as Microsoft Teams. The incumbent also is required to work collaboratively with colleagues to achieve project, team and organizational goals. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Therefore, effective oral/written communication and presentation skills are required.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. Fellows also are able to take part in Foundation for Advanced Education in the Sciences courses at NIH.

How to Apply

Please submit a cover letter describing your interest in the position, including a career synopsis (1–3 pages), a current curriculum vitae and complete bibliography, and the names and contact information of three references ATTN: Kirill Gorshkov, Ph.D., at NCATSTDBBioHiring@mail.nih.gov. The position will remain open for 60 days (beginning Feb. 16, 2021). Learn more about intramural research at NCATS.

Postdoctoral Medicinal Chemistry Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Therapeutic Development Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, is seeking a highly motivated synthetic chemist to serve as a postdoctoral fellow for drug discovery projects within the Therapeutic Development Branch (TDB) of its Division of Preclinical Innovation. The selected candidate will work on a multidisciplinary team to identify clinical candidates to address unmet medical needs.

Core Responsibilities

The postdoctoral fellow will be responsible for designing and synthesizing compounds for structure-activity relationship and structure-property relationship studies, developing new technologies to accelerate drug discovery, presenting results in internal and external meetings, and writing reports and manuscripts. The research will be conducted in the TDB medicinal chemistry group.

Qualifications

Applicants should have (or expect to receive) a Ph.D. in organic chemistry or medicinal chemistry at the time of joining the laboratory. The ideal candidate should be self-motivated, possess a strong work ethic, have keen attention to detail, and be able to work on multiple projects simultaneously. The candidate must possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. The fellow can take part in Foundation for Advanced Education in the Sciences courses at NIH, as well.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary, a current curriculum vitae, and the names of and contact information for three references to Wenwei Huang, Ph.D. at huangwe@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Genomic Toxicology Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Genomic Toxicology Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral position and apply genomic tools to toxicology and pharmacology in the Genomic Toxicology Laboratory within the Center’s Division of Preclinical Innovation (DPI). The Genomic Toxicology Laboratory, led by David L. Gerhold, Ph.D., participates in the Toxicology in the 21st Century (Tox21) program by developing methods to assess the effects of chemicals on human health, focusing on early stages of the translational process from target validation to first-in-human studies. This laboratory also develops novel human cellular 3-D and co-culture models to study cardiovascular disease, as well as neurological and renal diseases. DPI researchers collaborate closely with scientists in the 3-D Tissue Bioprinting Program, the Stem Cell Translational Laboratory, and the Therapeutics for Rare and Neglected Diseases program, as well as with other NIH Institutes and Centers and academic scientists. In addition to conducting cutting-edge laboratory research, DPI scientists work in a team-based environment and collaborate with more than 250 research organizations worldwide.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will complete the development and implementation of a novel high-throughput screening method that quantifies the expression of selected genes in cultured mammalian cells. The unprecedented throughput of this method will enable the screening of large chemical libraries of environmental toxicants or drug candidates. Because quantitative high-throughput screening of large chemical libraries is NCATS’ core expertise, the collaborative opportunities to apply this method to identify drug candidates and to screen Tox21 toxicant libraries are abundant. The successful applicant will work with collaborators who have developed induced Pluripotent Stem Cell (iPSC)–derived endothelial cells, as well as 3-D endothelial cell models that incorporate shear flow and co-culture with vascular smooth muscle cells. The postdoctoral candidate also will have opportunities to collaborate with scientists both within and outside of NCATS on additional projects. The selected candidate is expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals.

Qualifications

The ideal candidate will possess a doctoral degree (i.e., a Ph.D.) with a background in a relevant field of molecular or medical biology and have a strong record of high-impact publications. Applicants must possess molecular biology expertise and mammalian cell culture skills. Applicants also must possess strong oral and written English communication skills. Applicants with additional expertise in vascular biology or high-throughput screening will receive preferential consideration.

Applicants must be U.S. citizens or legal residents or must hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae and complete bibliography, and the names of and contact information for three references to David L. Gerhold, Ph.D., at NCATSGenomicTox@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Untargeted Metabolomics Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Informatics Core
Rockville, Maryland

Please Note: This position is the same position that currently is being advertised on NIH's Training & Education website.

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral untargeted, mass spectrometry–based metabolomics position in the Informatics Core within NCATS’ Division of Preclinical Innovation. The selected candidate must have experience in designing experiments, preparing samples, and developing and optimizing untargeted liquid chromatography with mass spectrometry (LC-MS) and LC-MS2 protocols, as well as a solid understanding of data analysis and bioinformatics techniques for integrating and interpreting large, multi-omic data sets.

The Informatics Core maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the Center. This interdisciplinary team of bioinformaticians, chemists and molecular biologists applies a metabolomics and multi-omics analysis approach to identifying dysregulated pathways and putative therapeutic targets. The team also has access to state-of-the art technologies, including a Thermo Scientific Orbitrap Fusion Lumos Tribrid MS with a FAIMS Pro module; an Agilent RapidFire 365 – QQQ (6470) high-throughput MS system; a Waters Xevo G2-XS QTOF with ACQUITY Bio UPLC; and a Bruker rapifleX® matrix-assisted laser desorption/ionization time-of-flight/time-of-flight system. Learn more about informatics research and scientific applications in the Division of Preclinical Innovation.

Core Responsibilities

The successful candidate will implement existing extraction and LC-MS research protocols; develop new, robust and reproducible extraction and LC-MS research protocols, including approach validation; work closely with bioinformaticians to evaluate the quality and reproducibility of metabolomic measurements and analysis and to integrate metabolomic data with other -omic data (e.g., transcriptome, microbiome, etc.); compile data and conduct preliminary statistical analyses (e.g., principal component analysis, univariate and multivariate testing, etc.); present results to the team and to the wider scientific community; draft manuscripts and publish results in peer-reviewed journals; and develop and implement novel approaches when standard approaches are not sufficient.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in metabolomics, biochemistry, analytical chemistry or a related field and have demonstrated hands-on experience in generating high-quality, untargeted, LC-MS-based metabolomic data. He or she should have experience handling a large number (e.g., hundreds) of samples; deconvoluting and filtering data; and assessing data quality, particularly mass spectrometry data (e.g., LC-MS, MS2, MSn, etc.). Applicants also should have basic knowledge and understanding of statistical analyses and functional interpretation of multi-omics data (e.g., principal components analysis, univariate/multivariate statistical methods, pathway enrichment methods, network analysis, etc.). Knowledge of R is a plus.

The selected candidate must have excellent interpersonal, verbal and written communication skills in English. He or she must possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. Although the team is highly collaborative in nature, the candidate’s pursuit of original research directions is highly encouraged. Applicants must be eligible to work in the United States for any employer.

Salary/Benefits

Salary is commensurate with other fellowship opportunities, and the position is renewable for up to 5 years.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (1–2 pages); a current curriculum vitae with complete bibliography; and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Mass Spectrometry Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Analytical Chemistry Core Facility
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation. The selected candidate must have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.

The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the Center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.

Core Responsibilities

The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

Qualifications

The successful applicant must possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a must. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable.

The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate must possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary (1–2 pages); a current curriculum vitae and complete bibliography; and the names of and contact information for at least three references to Christopher A. LeClair, Ph.D., at ncats_info@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Bioengineering Positions, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
3-D Tissue Bioprinting Laboratory
Rockville, Maryland

Description

NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill postdoctoral bioengineering positions in the Division’s 3-D Tissue Bioprinting Laboratory in Rockville, Maryland. The selected candidates must have expertise in biofabrication, biomaterials or microfluidics to help establish a portfolio of functional, physiologically complex 3-D tissue models as predictive screening platforms for toxicity and efficacy drug testing. Applicants with additional expertise in microphysiological systems, immunology, neuroscience and production of induced pluripotent stem cell-derived cells will receive preferential consideration.

Core Responsibilities

The candidates will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies—including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other cutting-edge “omics” technologiesto develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. They also will be expected to work independently as well-trained problem solvers in biofabrication and microfluidics, including on architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The successful candidates will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed.

Qualifications

Each applicant for this postdoctoral position must possess a Ph.D. in bioengineering, biomedical engineering, immunology, neuroscience, cell/molecular biology, pharmacology, pathology or a related discipline relevant to 3-D tissue models. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays—including work in such areas as organoids or biofabricated tissues, biomaterials, microfluidic systems, cell imaging, histology and engineering of cells with biosensors—as well as experience using bioprinting techniques, will be considered favorably. Candidates with a strong background in immunology and tissue engineering with induced pluripotent stem cell-derived cells are encouraged to apply. Applicants must be eligible to work in the United States for any employer.

How to Apply

Interested individuals should send a cover letter, a curriculum vitae with a bibliography, a one-page research proposal/plan for a physiologically complex 3-D tissues for disease modeling and compound testing, and the contact information for at least three references to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and will continue until these positions are filled.

Postdoctoral Computational Biologist/Bioinformatician, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Therapeutic Development Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral computational biologist/bioinformatician position in the NCATS Therapeutic Development Branch (TDB), within the Division of Preclinical Innovation.

TDB develops new systems, novel approaches and methodologies to achieve conceptual breakthroughs in preclinical therapeutics. The branch also provides collaborative access to technology and expertise in the scientific disciplines of early-discovery biology and medicinal chemistry; drug metabolism and pharmacokinetics; toxicology; and chemistry, manufacturing and controls synthesis and formulation.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will join an interdisciplinary team with a focus on profiling different cell types and responses in the context of rare genetic diseases, infectious diseases and drug treatments. He or she will be a bioinformatician/computational biologist with experience in bioinformatic analysis of NexGen sequencing datasets, with a strong emphasis in RNA-Seq analysis (bulk and single-cell). The fellow will collaborate with researchers in other universities and Institutes and will learn preclinical drug development from colleagues in multidisciplinary project teams. The fellow should obtain extensive experience and skills in this training program that can be applied toward translational research for therapeutics development.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in biology, computer sciences, bioinformatics or a related discipline, with one to three years of relevant research experience. Candidates should possess strong computer programming skills in R and other required languages (e.g., Python/Perl, Java, C/C++). Experience analyzing bulk and single-cell RNA-Seq data sets is essential. The candidate also should possess strong self-motivational and problem-solving skills, as well as outstanding interpersonal and teamwork skills. Excellent analytical, organizational and time management skills are required. Experience with proteomics data sets also is preferred, but not necessary. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position; a current curriculum vitae and complete bibliography; and the names of and contact information for three references to Wei Zheng, Ph.D., at NCATSTDBBioHiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Informatics Scientist, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group
Rockville, Maryland

Description

NCATS is one of the 27 Institutes and Centers at NIH. The Informatics group collaborates closely with biologists and chemists to develop robust assay designs, analyze experimental outcomes and validate new hypothesis. NCATS’ informatics personnel perform a variety of ligand- and protein structure-related modeling tasks, support the drug discovery process and accelerate translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.

NCATS’ Informatics group is seeking a creative, self-motivated postdoctoral informatics scientist to develop new algorithms for prediction of i) protein-ligand interactions; ii) chemical reactions and comprehensive support of drug discovery projects.

Core Responsibilities

The postdoctoral fellow will be responsible for uploading and analyzing pilot and quantitative high-throughput screening runs; analyzing assay reproducibility; analyzing confirmation and secondary screening assays; developing and applying QSAR models and molecular modeling for virtual screening of compounds; supporting medicinal chemistry efforts; and developing new algorithms for prediction of protein-ligand interactions and chemical reactions. Research will be conducted in the NCATS Informatics group.

Qualifications

The ideal candidate will possess a minimum of a Ph.D. in computational science/bioinformatics with specialization in machine learning. He or she will have published at least three research articles as first author. The successful candidatemust have experience with common cheminformatics libraries and data formats (e.g., RDKit, OpenBabel, SMILES, InChi, etc.), modern software packages (e.g., MOE/CCG, OpenEye tools) and scientific programming (e.g., Python, JAVA) and data analytics (e.g., KNIME, Spotfire). He or she must be able to script work flows and implement new algorithms, have experience working with multi-disciplinary teams, and possess strong oral and written English communication skills. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras), as well as experience in developing algorithms for prediction of protein-ligand interactions and/or chemical reactions.

Applicants must be U.S. citizens or legal residents or must hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in this position, a current curriculum vitae and complete bibliography to Alexey V. Zakharov, Ph.D., at alexey.zakharov@nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Informatics Scientist Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Informatics Group
Rockville, Maryland

Description

NCATS’ Informatics group seeks a creative, self-motivated, collaborative research scientist to develop new algorithms for predicting chemical reactions and to provide comprehensive support of the Center’s A Specialized Platform for Innovative Research Exploration (ASPIRE) initiative.

NCATS proposes to transform chemistry from an individualized craft to a modern, information-based science through ASPIRE. By addressing long-standing challenges in the field of chemistry — including lack of standardization, low reproducibility and an inability to predict how new chemicals will behave — ASPIRE is designed to bring novel, safe and effective treatments to more patients more quickly at lower cost.

The Informatics group collaborates closely with biologists, chemists, engineers and information technology professionals to develop robust assay designs, analyze experimental outcomes and to validate new hypothesis. The NCATS Informatics group performs a variety of ligand- and protein structure-related modeling tasks, supports the drug discovery process and accelerates translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.

Core Responsibilities

The successful candidate will be an integral team member for the creation and maintenance of a chemical reaction database, the development of new methods for reaction normalization and standardization, the analysis of reaction screens, and the development and application of AI/Machine learning approaches for prediction of synthetic routes and chemical reactions. He or she also must have experience working with multi-disciplinary teams.

Qualifications

Applicants must possess a minimum of a Ph.D. in computational chemistry or a related field with 1 to 3 years of industry or academic experience. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras, sklearn, PyTorch, etc.) Applicants also should have experience with common cheminformatics libraries and data formats (e.g., RDKit, Indigo, CDK, SMIRKS, SMARTS, SMILES, InChi, etc.), as well as experience in scientific programming (e.g., Python, JAVA), data analytics (e.g., KNIME, Spotfire) and relational databases (e.g., Oracle, SQL). Additionally, applicants must be able to script work flows and implement new algorithms. Applicants also must possess strong oral and written English communication skills.

How to Apply

Please submit a cover letter describing your interest in this position, a current curriculum vitae and complete bibliography (all in PDF format), and three letters of reference to Alexey V. Zakharov, Ph.D., at NCATSAspire-Hires@nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Stem Cell Scientist and Postdoctoral Positions, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from qualified candidates with expertise in developmental biology and human induced pluripotent stem cells (iPSCs) to fill stem cell scientist and postdoctoral positions in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the Center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as iPSCs, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems. Successful candidates will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS, external service providers and collaborators at top academic institutions.

Core Responsibilities

The selected candidates will join a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, compound management, automation engineering, bioinformatics, medicinal chemistry and various “-omics” technologies. They will work in a highly creative environment, focusing on important aspects of human pluripotency and cellular differentiation using cutting-edge technologies (e.g., single-cell analysis, deep sequencing, robotic cell culture, high-throughput electrophysiology, genome editing). They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Qualifications

Each applicant must possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Exceptional candidates with master’s degrees and strong backgrounds in stem cell biology will be considered. Candidates with experience in drug discovery, cell and tissue engineering, cell signaling, or quantitative biology are encouraged to apply. The ideal candidates should be team players with high scientific standards and have the ability to work in an interactive, fast-paced environment. They must be self-motivated to learn new technologies and be familiar with the methods and concepts of stem cell biology and regenerative medicine.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. Fellows also are able to take part in Foundation for Advanced Education in the Sciences courses at NIH.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae and complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.