Job Opportunities

NCATS is looking for innovative partners to join its dynamic team. Learn more about current job opportunities at NCATS or across NIH and the U.S. Department of Health and Human Services (HHS). NIH and HHS are Equal Opportunity Employers.

All information provided by candidates will remain confidential and will not be released outside the NCATS search process without a signed release from candidates. NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. DHHS and NIH are Equal Opportunity Employers. NIH is dedicated to building a diverse community in its training and employment programs.

Current Vacancies

Postdoctoral Positions in the Division of Preclinical Innovation

Associate Director of Clinical Affairs for the Clinical and Translational Science Awards (CTSA) Program and Chief of the CTSA Program’s Clinical Affairs Branch

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Clinical Innovation
Bethesda, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional candidates with recognized leadership and demonstrated innovation and expertise in current clinical research, clinical trials, translational science, regulatory compliance, quality improvements epidemiology and public health research to serve as the associate director of Clinical Affairs for the Clinical and Translational Science Awards (CTSA) Program and chief of the CTSA Program’s Clinical Affairs Branch in its Division of Clinical Innovation (DCI).

Core Responsibilities

The associate director of Clinical Affairs for the CTSA Program and chief of the CTSA Program’s Clinical Affairs Branch within DCI is responsible for the overall stewardship of all medically related activities under the NCATS CTSA Program, which includes the Trial Innovation Network and related CTSA clinical research and clinical resources. The incumbent also interacts directly with the NCATS director on vision and strategy regarding the Center’s mission and collaborations across and beyond NIH.

Qualifications

The ideal candidate will possess a record of accomplishment and innovation in clinical and translational processes and an outstanding record of scientific accomplishment in public and/or private sector research. Each applicant must possess an M.D. or an equivalent degree, as well as senior-level experience, leadership and accomplishment in one or more medical and/or scientific disciplines of translational science, from target validation to health care utilization research. Experience in running large, complex, multidisciplinary and dynamic programs is desired, with particular strength in human-subjects research, regulatory science and policy. Candidates should demonstrate a clear pattern of success in setting, planning, implementing and analyzing research project or program objectives and priorities; the ability to manage financial and human resources in leading research projects or programs involving extensive internal and external collaboration; the ability to communicate effectively with diverse scientific and lay audiences; and the ability to form collaborations with national and international organizations, as well as with individuals who represent wide-ranging disciplines and competing priorities.

Salary/Benefits

The associate director of Clinical Affairs for the Clinical and Translational Science Awards (CTSA) Program and chief of the CTSA Program’s Clinical Affairs Branch will be appointed at a salary commensurate with his or her qualifications and experience. Full federal benefits — including leave, health and life insurance, long-term care insurance, and retirement and savings plan (401K equivalent) — will be provided.

How to Apply

Interested individuals should submit applications from July 21 to August 20, 2021 (submission deadline may be extended if needed). Applicants should submit a cover letter describing their interest in the position and a curriculum vitae with a complete bibliography to NCATSSBRBPASPosition@nih.gov. Include your name and CTSA Program Clinical Affairs Chief Position in the subject line. Please submit questions about this position to Clare K. Schmitt, Ph.D., via Clare.Schmitt@nih.gov. Review of applications will begin August 21, 2021 and will continue until the position is filled.

Do not include your birthdate or social security number on application materials.

Associate Director of the Clinical and Translational Science Awards (CTSA) Program and Chief of the CTSA Program Branch, Division of Clinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Clinical Innovation
Bethesda, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional candidates with expertise in basic research and translational science, and with experience in multiple disciplines, including the broad application of information technology, to serve as the associate director of the Clinical and Translational Science Awards (CTSA) Program and chief of the CTSA Program Branch in its Division of Clinical Innovation (DCI). Familiarity with specific NIH grant mechanisms (e.g., UM1, U24, etc.) and a proven track record of managing complex clinical research networks also is essential.

Core Responsibilities

The associate director of the CTSA Program and chief of the CTSA Program Branch within DCI is responsible for providing leadership and overseeing all activities of the CTSA Program Hubs under the NCATS CTSA Program. The incumbent also interacts directly with the NCATS director on vision and strategy regarding the Center’s mission and collaborations across and beyond the NIH.

Qualifications

The ideal candidate will possess a record of accomplishment and innovation in clinical and translational processes and an outstanding record of scientific accomplishment in public- and/or private-sector research. Each applicant must possess a Ph.D. or an equivalent degree, as well as senior-level experience, leadership and accomplishment in one or more scientific disciplines of translational science, from target validation to health care utilization research. Experience in multiple disciplines is required, including the broad application of information technology; interpretation of information from a wide variety of sources, including biological sequences and molecules; potential research uses of electronic health records; and issues related to clinical studies, clinical trials and rare diseases. As a result, the incumbent must be familiar with NIH and U.S. Department of Health and Human Services human subjects’ policies; with Institutional Review Board policies and subject safety; and with data sharing and confidentiality issues. The incumbent also must have familiarity with specific NIH grant mechanisms (e.g., UM1, U24, etc.) and complex clinical research networks. This position requires an individual with expertise in basic research, translational science and management of large networks. Candidates should demonstrate a clear pattern of success in setting, planning, implementing and analyzing research project or program objectives and priorities; the ability to manage financial and human resources in leading research projects or programs involving extensive internal and external collaboration; the ability to communicate effectively with diverse scientific and lay audiences; and the ability to form collaborations with national and international organizations, as well as with individuals who represent wide-ranging disciplines and competing priorities.

Salary/Benefits

The associate director of the CTSA Program and chief of the CTSA Program Branch will be appointed at a salary commensurate with his/her qualifications and experience. Full federal benefits — including leave, health and life insurance, long-term care insurance, and retirement and savings plan (401K equivalent) — will be provided.

How to Apply

Interested individuals should submit applications from July 21 to August 20, 2021 (submission deadline may be extended if needed). Applicants should submit a cover letter describing their interest in the position and a curriculum vitae with a complete bibliography to NCATSSBRBPASPosition@nih.gov. Include your name and CTSA Program Chief Position in the subject line. Please submit questions about this position to Clare K. Schmitt, Ph.D., at Clare.Schmitt@nih.gov. Review of applications will begin August 21, 2021 and will continue until the position is filled.

Do not include your birthdate or social security number on application materials.

Research Associate (Biology), Chemical Technologies Group, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Technologies Group
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research associate (biology) position in the Chemical Technology group within its Division of Preclinical Innovation in Rockville, Maryland. The Division of Preclinical Innovation is home to approximately 230 biologists, medicinal and process chemists, and computational scientists who work on a broad portfolio of preclinical drug discovery projects, as well as programs that involve the development of innovative new technologies to enable the acceleration of biomedical research. The Chemical Technology group operates at the interface between chemistry and biology. A major focus of the team involves conducting large-scale chemogenomic screenings to identify novel targets and to develop novel strategies for therapeutic intervention, mostly focusing on oncologic indications. A second major focus of the team involves the discovery, optimization and advancement of novel biologically active small molecules.

Core Responsibilities

The selected candidate will maintain mammalian cell-line cultures and expand them to scale in preparation of high-throughput drug screening; prepare various media, stock supplies and other reagents for use in the laboratory; perform in vitro cell-based assays to support the molecular characterization of drugs’ mechanism of action. These include DNA/RNA extraction, PCR and western-blot. The incumbent also will maintain accurate daily records of experiments and results and interpret, evaluate and discuss the result of each experiment as part of the experimental-planning process. The selected candidate will perform computer analysis of data and use various software to prepare data figures for both internal discussion and publication.

Qualifications

Applicants to this research associate (biology) position should possess a bachelor's degree in biology, biochemistry or other related life science discipline. A master’s in cell biology, immunology, biochemistry or other related life science discipline is preferred. The selected candidate should possess a conceptual understanding of cancer biology and knowledge of major oncogenic signaling pathways in human cancers, a strong background in cell biology, have at least two years of previous experience with standard molecular biology techniques (e.g., tissue culture, RNA and DNA extraction, PCR and western-blot) and be proficient at the bench. He or she should demonstrate attention to detail and possess strong organizational and interpersonal skills. Applicants also should possess excellent verbal and written communication skills, the ability to interpret, summarize and present scientific results in a clear, concise and accurate manner; and be able to work productively as a member of a diverse and dynamic multidisciplinary team.

The ideal candidate will have previous experience with high-throughput drug screening, Illumina next-generation sequencing platforms and related library preparation procedures (especially RNA-Seq and single-cell analysis), as well as documented knowledge of the hippo signaling pathway. Previous experience in microscopy, immunocytochemistry and flow cytometry, as well as strong computer literacy and Microsoft Excel proficiency — particularly with respect to graph/plots generation and analysis of large data sets — will be considered a plus.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to ncatspt3hiring@mail.nih.gov. The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Research Scientist (Virology) Position, 3-D Tissue Bioprinting Laboratory, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
3-D Tissue Bioprinting Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research scientist (virology) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation in Rockville, Maryland.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge technologies — including tissue biofabrication, tissue chips, quantitative cell imaging, histology, assay development, drug screening, data science and other “omics” technologies (e.g., scRNAseq) — to develop advanced 3-D cellular models to study viral infections and drug screening. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. The selected candidate also will be expected to work independently as a well-trained problem solver in virology. Effective communication and presentation skills are required. The incumbent will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The selected candidate will draft technical reports, manuscripts and patent applications, and present work to internal and external collaborators as needed. The incumbent also must be eligible to work in the U.S. with whomever NCATS collaborates worldwide.

Qualifications

Applicants to this research scientist position must possess a Ph.D. in virology, cell or molecular biology or pharmacology, and at least 3 years of postdoctoral experience. The selected candidate must have expertise in virology to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and drug testing. Applicants should have additional expertise in histology, fluorescence microscopy, flow cytometry, single-cell RNA sequencing (scRNAseq), and production of induced pluripotent stem cell-derived cells. Candidates with previous experience working in a BSL3 lab and in areas such as organoids, tissue chip, cell imaging, histology and engineering of cells with biosensors will be considered favorably.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for 3 references, including your current supervisor, to NCATSbioprinting@mail.nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Bioinformatician, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a bioinformatician position in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the Center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as induced pluripotent stem cells, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems.

The successful candidate will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS and collaborators at top academic institutions.

Core Responsibilities

Computational analysis is integral to the laboratory’s efforts in the deep characterization of stem cell states and functional cell types from different developmental lineages. The bioinformatician will be required to promptly turn around analysis results to respond to biologists’ ongoing projects, work on multiple projects in parallel, and coordinate and oversee data analysis with external service providers.

Qualifications

Applicants should have a master’s degree or higher in bioinformatics, computational biology or biomedical data science. The ideal candidate should have strong science communication skills; clear and effective data visualization skills; the ability to work well independently and in a team environment; creative problem-solving skills; and a proven ability to apply the cutting-edge, rigorous standards of the bioinformatics fields. Applicants should possess a solid knowledge of R statistical programming language; familiarity with the handling, management and storage of large-scale sequencing data; and experience querying public databases, including the SRA, GEO and dbGaP.

Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms (e.g., bulk and single-cell RNA-Seq; ChIP-seq methods, such as MeDIP-seq; bulk and single-cell ATAC-seq; and miRNA-seq). Experience with other ‑omics — such as WES, WGS and targeted sequencing methods — are a plus. The ideal candidate will have experience with pre-processing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, HTSeq, featureCounts, salmon, GATK) and R packages designed for the above-mentioned methods (e.g., DESeq2, limma, Seurat). A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of NIH’s high-performance computing capabilities, are preferred.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Positions in the Division of Preclinical Innovation

The Division of Preclinical Innovation (DPI) is the intramural (i.e., on-site) research program of NCATS and is located in Rockville, Maryland, a few miles from the main NIH campus in Bethesda, Maryland. DPI focuses on early stages of the translational process, from target validation to first-in-human studies. More than 200 scientists from a variety of disciplines and across the spectrum from early-career scientists to senior leaders are responsible for advancing the diverse research portfolio of DPI. In addition to conducting cutting-edge laboratory research, DPI scientists collaborate with more than 250 research organizations worldwide.

DPI scientists work in a collaborative, team-based environment. The postdoctoral candidate will be recruited to work on the specific projects described below and will have ample opportunities to collaborate with scientists both within and outside of NCATS on additional projects. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Postdoctoral fellows also gain additional professional skills and exposure to a variety of career paths through participation in the DPI training program.

Postdoctoral Biomedical Engineer Position, 3-D Tissue Bioprinting Laboratory, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
3-D Tissue Bioprinting Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral biomedical engineering position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. The selected candidate must have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology, fluorescence microscopy and experience working with primary cells or induced pluripotent stem cell-derived cells.

Core Responsibilities

The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other “omics” technologies including scRNAseq — to develop advanced cellular models for drug discovery and development. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The incumbents will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and present work to internal and external collaborators as needed. The incumbents also must be eligible to work in the U.S. with whomever NCATS collaborates worldwide.

Qualifications

Each applicant to this postdoctoral position must possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in areas such as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology and engineering of cells with biosensors — will be considered favorably.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. The fellow also may take part in Foundation for Advanced Education in the Sciences courses at NIH.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for 2–3 references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Antibody Discovery and Characterization Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Early Translational Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, is seeking applications from exceptional candidates to hold a postdoctoral position in antibody discovery and characterization in the Early Translational Branch (ETB) of its Division of Preclinical Innovation, located in Rockville, Maryland. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.

The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment and be exposed to cutting-edge high-throughput screening, assay biology, bioinformatics, medicinal chemistry and disease-relevant biological models. They will implement antibody discovery technologies (including phage display), directed evolution, and related technologies to produce and characterize antibodies relevant to diseases and conditions related to pain, addiction and overdose, and other public health emergencies, such as the SARS-CoV-2 pandemic. The incumbent will apply cutting-edge cell biology and bioassay technologies for the development of disease-relevant antibody selection and screening assays and will be involved in all aspects of the implementation, including assay design, assay development and optimization, antibody screening, protein engineering, data analysis and mechanism-of-action studies.

Core Responsibilities

The selected candidate must be able to work independently under team supervision. The incumbent will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports and manuscripts and will present work internally and to external collaborators as needed.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, pharmacology or a related discipline. Experience with antibody phage display technologies — including panning, ELISA, and protein purification — and an understanding of antibody domain architecture are highly desirable. The candidate should be an independent thinker, a team player, and able to work in a very interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. The fellow also may take part in Foundation for Advanced Education in the Sciences courses at NIH.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSantibody_hiring@nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Medicinal Chemistry Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Early Translational Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to hold a 2- to 3-year postdoctoral position in medicinal chemistry in the Early Translational Branch (ETB) of its Division of Preclinical Innovation, located in Rockville, Maryland. The selected candidate will join a multidisciplinary biology, chemistry, and informatics team, working with external biology and disease experts on projects aligned with the Helping to End Addiction Long-term℠ Initiative, or NIH HEAL Initiative℠. The candidate will be leading several projects under a mentor and expected to design, synthesize, and optimize potential probe molecules and preclinical candidates against novel targets and pathways designed to address unmet medical needs related to pain, addiction and overdose. The selected candidate will work under the mentorship of a chemistry team leader and be exposed to cutting-edge high-throughput screening, assay biology, bioinformatics, medicinal chemistry, and disease-relevant biological models.

Core Responsibilities

The selected candidate must be able to work independently and be well trained in multistep organic synthesis with the ability to synthesize, purify, identify, characterize and analyze compounds using nuclear magnetic resonance (NMR), infrared spectroscopy and mass spectrometry. The incumbent will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work internally and to external consultants and collaborators as needed. An understanding of and previous exposure to structure–activity relationship studies and absorption, distribution, metabolism and excretion optimization is desirable, but not necessary.

Qualifications

Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in organic chemistry and/or medicinal chemistry. Experience in drug discovery and optimization is desirable, but not necessary. The candidate should be an independent thinker and team player and be able to work in a very interactive, fast-paced environment. Applicants must be well trained in the methods and concepts of organic chemistry and must have experience in organic synthesis (experience in heterocyclic chemistry is desirable); purification and analysis of reaction products; methodology development; design of novel analogs; and design and testing of synthetic routes to novel compounds by proposing and reducing to practice multistep syntheses. Furthermore, experience in standard spectroscopic and purification methods — including Fourier transform NMR, standard or automated liquid chromatography, and high-performance liquid chromatography methods — is required.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. The fellow also may take part in Foundation for Advanced Education in the Sciences courses at NIH.

How to Apply

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for 2–3 references, including your current supervisor, to ETB Team Leads Ganesha Rai (bantukallug@mail.nih.gov) or Samarjit Patnaik (patnaiks@mail.nih.gov).

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Fellow in Clinical and Biomedical Informatics, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
DPI Informatics Core
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellowship position in the Informatics Core within the Center’s Division of Preclinical Innovation. Applicants to this intramural program should have a background in clinical informatics with an interest in data science. The Informatics Core is a dynamic, interdisciplinary team of clinical, bio- and chem-informaticians, translational researchers, and project managers interested in evaluating drug–disease relationships. For these assessments, the team uses knowledge sources containing clinical, -omic and in vitro assay data (e.g., high-throughput screening) that are curated and/or supported and managed at NCATS. Relevant knowledge sources include but are not limited to the Genetic and Rare Diseases Information Center (GARD), Pharos and Inxight. The goal is to bridge preclinical and clinical assessments to find new putative targets.

Candidates with a solid understanding in database management, integration of multiple data sources, data cleaning/processing/harmonization, interoperability and machine learning are preferred. Experience with various types of data sets as listed above is preferred. Although the team is highly collaborative in nature, the candidate’s pursuit of original research directions is strongly encouraged.

Core Responsibilities

The successful candidate will collect, analyze and curate data from clinical trials, U.S. Food and Drug Administration (FDA) drug labels and FDA orphan designations to elucidate the therapeutic development landscape of diseases, including rare diseases. He or she will identify relevant associations of clinical and molecular factors (e.g., genetic, -omics, etc.) and disease, including rare outcomes and response to treatments. Patient data will be accessed through various electronic health records systems, resources and programs available at NIH (e.g., Biomedical Translational Research Information System, NIH Clinical Center, Clinical and Translational Science Awards [CTSA] Program Data to Health Coordination Center [CD2H], National COVID Cohort Collaborative [N3C] and the Biomedical Data Translator program). The successful candidate then will develop new and robust code to automate the use — and augment data resources — of existing knowledge warehouses, including those developed within NCATS, and contribute to efforts for standardizing and developing new ontologies (e.g., GARD ontology, etc.). He or she is expected to use state-of-the-art linear and nonlinear multivariable modeling and machine learning to identify aforementioned relevant associations and to support clinical decision-making. The candidate will work closely with bioinformaticians, scientists and clinicians to interpret findings and identify areas that require further investigation (e.g., screening or molecular profiling). He or she will present results to the team and to the wider scientific community, draft manuscripts and publish results in peer-reviewed journals, and develop and implement novel approaches when standard approaches are not sufficient.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in clinical informatics, biomedical informatics, bioinformatics, or a related field and have demonstrated hands-on experience in leading the analysis of a large (multiple hundreds or greater) cohort data set. He or she should have demonstrated experience in organizing, cleaning and harmonizing large data sets, as well as in applying robust statistical methods, including multivariable analyses, machine learning, etc. Knowledge of R and/or Python is required, and basic knowledge and understanding of clinical and biological interpretation of molecular data (e.g., -omics, assay screening data, etc.) is preferred.

The selected candidate must have excellent interpersonal, verbal and written communication skills in English and must possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. Applicants must be eligible to work in the United States for any employer.

Stipends

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale. The position is renewable for up to five years.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (1–2 pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Medicinal Chemistry Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Therapeutic Development Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, is seeking a highly motivated synthetic chemist to serve as a postdoctoral fellow for drug discovery projects within the Therapeutic Development Branch (TDB) of its Division of Preclinical Innovation. The selected candidate will work on a multidisciplinary team to identify clinical candidates to address unmet medical needs.

Core Responsibilities

The postdoctoral fellow will be responsible for designing and synthesizing compounds for structure-activity relationship and structure-property relationship studies, developing new technologies to accelerate drug discovery, presenting results in internal and external meetings, and writing reports and manuscripts. The research will be conducted in the TDB medicinal chemistry group.

Qualifications

Applicants should have (or expect to receive) a Ph.D. in organic chemistry or medicinal chemistry at the time of joining the laboratory. The ideal candidate should be self-motivated, possess a strong work ethic, have keen attention to detail, and be able to work on multiple projects simultaneously. The candidate must possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. The fellow can take part in Foundation for Advanced Education in the Sciences courses at NIH, as well.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary, a current curriculum vitae, and the names of and contact information for three references to Wenwei Huang, Ph.D. at huangwe@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Genomic Toxicology Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Genomic Toxicology Laboratory
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral position and apply genomic tools to toxicology and pharmacology in the Genomic Toxicology Laboratory within the Center’s Division of Preclinical Innovation (DPI). The Genomic Toxicology Laboratory, led by David L. Gerhold, Ph.D., participates in the Toxicology in the 21st Century (Tox21) program by developing methods to assess the effects of chemicals on human health, focusing on early stages of the translational process from target validation to first-in-human studies. This laboratory also develops novel human cellular 3-D and co-culture models to study cardiovascular disease, as well as neurological and renal diseases. DPI researchers collaborate closely with scientists in the 3-D Tissue Bioprinting Program, the Stem Cell Translational Laboratory, and the Therapeutics for Rare and Neglected Diseases program, as well as with other NIH Institutes and Centers and academic scientists. In addition to conducting cutting-edge laboratory research, DPI scientists work in a team-based environment and collaborate with more than 250 research organizations worldwide.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will complete the development and implementation of a novel high-throughput screening method that quantifies the expression of selected genes in cultured mammalian cells. The unprecedented throughput of this method will enable the screening of large chemical libraries of environmental toxicants or drug candidates. Because quantitative high-throughput screening of large chemical libraries is NCATS’ core expertise, the collaborative opportunities to apply this method to identify drug candidates and to screen Tox21 toxicant libraries are abundant. The successful applicant will work with collaborators who have developed induced Pluripotent Stem Cell (iPSC)–derived endothelial cells, as well as 3-D endothelial cell models that incorporate shear flow and co-culture with vascular smooth muscle cells. The postdoctoral candidate also will have opportunities to collaborate with scientists both within and outside of NCATS on additional projects. The selected candidate is expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals.

Qualifications

The ideal candidate will possess a doctoral degree (i.e., a Ph.D.) with a background in a relevant field of molecular or medical biology and have a strong record of high-impact publications. Applicants must possess molecular biology expertise and mammalian cell culture skills. Applicants also must possess strong oral and written English communication skills. Applicants with additional expertise in vascular biology or high-throughput screening will receive preferential consideration.

Applicants must be U.S. citizens or legal residents or must hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to David L. Gerhold, Ph.D., at NCATSGenomicTox@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Untargeted Metabolomics Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Informatics Core
Rockville, Maryland

Please Note: This position is the same position that currently is being advertised on NIH's Training & Education website.

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral untargeted, mass spectrometry–based metabolomics position in the Informatics Core within NCATS’ Division of Preclinical Innovation. The selected candidate must have experience in designing experiments, preparing samples, and developing and optimizing untargeted liquid chromatography with mass spectrometry (LC-MS) and LC-MS2 protocols, as well as a solid understanding of data analysis and bioinformatics techniques for integrating and interpreting large, multi-omic data sets.

The Informatics Core maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the Center. This interdisciplinary team of bioinformaticians, chemists and molecular biologists applies a metabolomics and multi-omics analysis approach to identifying dysregulated pathways and putative therapeutic targets. The team also has access to state-of-the art technologies, including a Thermo Scientific Orbitrap Fusion Lumos Tribrid MS with a FAIMS Pro module; an Agilent RapidFire 365 – QQQ (6470) high-throughput MS system; a Waters Xevo G2-XS QTOF with ACQUITY Bio UPLC; and a Bruker rapifleX® matrix-assisted laser desorption/ionization time-of-flight/time-of-flight system. Learn more about informatics research and scientific applications in the Division of Preclinical Innovation.

Core Responsibilities

The successful candidate will implement existing extraction and LC-MS research protocols; develop new, robust and reproducible extraction and LC-MS research protocols, including approach validation; work closely with bioinformaticians to evaluate the quality and reproducibility of metabolomic measurements and analysis and to integrate metabolomic data with other -omic data (e.g., transcriptome, microbiome, etc.); compile data and conduct preliminary statistical analyses (e.g., principal component analysis, univariate and multivariate testing, etc.); present results to the team and to the wider scientific community; draft manuscripts and publish results in peer-reviewed journals; and develop and implement novel approaches when standard approaches are not sufficient.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in metabolomics, biochemistry, analytical chemistry or a related field and have demonstrated hands-on experience in generating high-quality, untargeted, LC-MS-based metabolomic data. He or she should have experience handling a large number (e.g., hundreds) of samples; deconvoluting and filtering data; and assessing data quality, particularly mass spectrometry data (e.g., LC-MS, MS2, MSn, etc.). Applicants also should have basic knowledge and understanding of statistical analyses and functional interpretation of multi-omics data (e.g., principal components analysis, univariate/multivariate statistical methods, pathway enrichment methods, network analysis, etc.). Knowledge of R is a plus.

The selected candidate must have excellent interpersonal, verbal and written communication skills in English. He or she must possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. Although the team is highly collaborative in nature, the candidate’s pursuit of original research directions is highly encouraged. Applicants must be eligible to work in the United States for any employer.

Salary/Benefits

Salary is commensurate with other fellowship opportunities, and the position is renewable for up to 5 years.

How to Apply

Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (1–2 pages); a current curriculum vitae with a complete bibliography; and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.

The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

Postdoctoral Mass Spectrometry Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Analytical Chemistry Core Facility
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation. The selected candidate must have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.

The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the Center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.

Core Responsibilities

The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

Qualifications

The successful applicant must possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a must. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable.

The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate must possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position, including a research summary (1–2 pages); a current curriculum vitae with a complete bibliography; and the names of and contact information for at least three references to Christopher A. LeClair, Ph.D., at ncats_info@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Bioengineering Positions, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
3-D Tissue Bioprinting Laboratory
Rockville, Maryland

Description

NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill postdoctoral bioengineering positions in the Division’s 3-D Tissue Bioprinting Laboratory in Rockville, Maryland. The selected candidates must have expertise in biofabrication, biomaterials or microfluidics to help establish a portfolio of functional, physiologically complex 3-D tissue models as predictive screening platforms for toxicity and efficacy drug testing. Applicants with additional expertise in microphysiological systems, immunology, neuroscience and production of induced pluripotent stem cell-derived cells will receive preferential consideration.

Core Responsibilities

The candidates will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies—including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other cutting-edge “omics” technologiesto develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. They also will be expected to work independently as well-trained problem solvers in biofabrication and microfluidics, including on architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The successful candidates will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed.

Qualifications

Each applicant for this postdoctoral position must possess a Ph.D. in bioengineering, biomedical engineering, immunology, neuroscience, cell/molecular biology, pharmacology, pathology or a related discipline relevant to 3-D tissue models. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays—including work in such areas as organoids or biofabricated tissues, biomaterials, microfluidic systems, cell imaging, histology and engineering of cells with biosensors—as well as experience using bioprinting techniques, will be considered favorably. Candidates with a strong background in immunology and tissue engineering with induced pluripotent stem cell-derived cells are encouraged to apply. Applicants must be eligible to work in the United States for any employer.

How to Apply

Interested individuals should send a cover letter, a curriculum vitae with a complete bibliography, a one-page research proposal/plan for a physiologically complex 3-D tissues for disease modeling and compound testing, and the contact information for at least three references to NCATSbioprinting@mail.nih.gov.

The review of applications will begin immediately and will continue until these positions are filled.

Postdoctoral Computational Biologist/Bioinformatician, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Therapeutic Development Branch
Rockville, Maryland

Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral computational biologist/bioinformatician position in the NCATS Therapeutic Development Branch (TDB), within the Division of Preclinical Innovation.

TDB develops new systems, novel approaches and methodologies to achieve conceptual breakthroughs in preclinical therapeutics. The branch also provides collaborative access to technology and expertise in the scientific disciplines of early-discovery biology and medicinal chemistry; drug metabolism and pharmacokinetics; toxicology; and chemistry, manufacturing and controls synthesis and formulation.

Core Responsibilities

The selected candidate — a self-motivated, collaborative postdoctoral fellow — will join an interdisciplinary team with a focus on profiling different cell types and responses in the context of rare genetic diseases, infectious diseases and drug treatments. He or she will be a bioinformatician/computational biologist with experience in bioinformatic analysis of NexGen sequencing datasets, with a strong emphasis in RNA-Seq analysis (bulk and single-cell). The fellow will collaborate with researchers in other universities and Institutes and will learn preclinical drug development from colleagues in multidisciplinary project teams. The fellow should obtain extensive experience and skills in this training program that can be applied toward translational research for therapeutics development.

Qualifications

The ideal candidate should possess a doctoral degree or equivalent in biology, computer sciences, bioinformatics or a related discipline, with one to three years of relevant research experience. Candidates should possess strong computer programming skills in R and other required languages (e.g., Python/Perl, Java, C/C++). Experience analyzing bulk and single-cell RNA-Seq data sets is essential. The candidate also should possess strong self-motivational and problem-solving skills, as well as outstanding interpersonal and teamwork skills. Excellent analytical, organizational and time management skills are required. Experience with proteomics data sets also is preferred, but not necessary. Applicants must be eligible to work in the United States for any employer.

How to Apply

Please submit a cover letter describing your interest in the position; a current curriculum vitae with a complete bibliography; and the names of and contact information for three references to Wei Zheng, Ph.D., at NCATSTDBBioHiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Informatics Scientist, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group
Rockville, Maryland

Description

NCATS is one of the 27 Institutes and Centers at NIH. The Informatics group collaborates closely with biologists and chemists to develop robust assay designs, analyze experimental outcomes and validate new hypothesis. NCATS’ informatics personnel perform a variety of ligand- and protein structure-related modeling tasks, support the drug discovery process and accelerate translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.

NCATS’ Informatics group is seeking a creative, self-motivated postdoctoral informatics scientist to develop new algorithms for prediction of i) protein-ligand interactions; ii) chemical reactions and comprehensive support of drug discovery projects.

Core Responsibilities

The postdoctoral fellow will be responsible for uploading and analyzing pilot and quantitative high-throughput screening runs; analyzing assay reproducibility; analyzing confirmation and secondary screening assays; developing and applying QSAR models and molecular modeling for virtual screening of compounds; supporting medicinal chemistry efforts; and developing new algorithms for prediction of protein-ligand interactions and chemical reactions. Research will be conducted in the NCATS Informatics group.

Qualifications

The ideal candidate will possess a minimum of a Ph.D. in computational science/bioinformatics with specialization in machine learning. He or she will have published at least three research articles as first author. The successful candidatemust have experience with common cheminformatics libraries and data formats (e.g., RDKit, OpenBabel, SMILES, InChi, etc.), modern software packages (e.g., MOE/CCG, OpenEye tools) and scientific programming (e.g., Python, JAVA) and data analytics (e.g., KNIME, Spotfire). He or she must be able to script work flows and implement new algorithms, have experience working with multi-disciplinary teams, and possess strong oral and written English communication skills. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras), as well as experience in developing algorithms for prediction of protein-ligand interactions and/or chemical reactions.

Applicants must be U.S. citizens or legal residents or must hold a valid work permit to be considered for the position.

How to Apply

Please submit a cover letter describing your interest in this position, a current curriculum vitae with a complete bibliography to Alexey V. Zakharov, Ph.D., at alexey.zakharov@nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Informatics Scientist Position, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Informatics Group
Rockville, Maryland

Description

NCATS’ Informatics group seeks a creative, self-motivated, collaborative research scientist to develop new algorithms for predicting chemical reactions and to provide comprehensive support of the Center’s A Specialized Platform for Innovative Research Exploration (ASPIRE) initiative.

NCATS proposes to transform chemistry from an individualized craft to a modern, information-based science through ASPIRE. By addressing long-standing challenges in the field of chemistry — including lack of standardization, low reproducibility and an inability to predict how new chemicals will behave — ASPIRE is designed to bring novel, safe and effective treatments to more patients more quickly at lower cost.

The Informatics group collaborates closely with biologists, chemists, engineers and information technology professionals to develop robust assay designs, analyze experimental outcomes and to validate new hypothesis. The NCATS Informatics group performs a variety of ligand- and protein structure-related modeling tasks, supports the drug discovery process and accelerates translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.

Core Responsibilities

The successful candidate will be an integral team member for the creation and maintenance of a chemical reaction database, the development of new methods for reaction normalization and standardization, the analysis of reaction screens, and the development and application of AI/Machine learning approaches for prediction of synthetic routes and chemical reactions. He or she also must have experience working with multi-disciplinary teams.

Qualifications

Applicants must possess a minimum of a Ph.D. in computational chemistry or a related field with 1 to 3 years of industry or academic experience. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras, sklearn, PyTorch, etc.) Applicants also should have experience with common cheminformatics libraries and data formats (e.g., RDKit, Indigo, CDK, SMIRKS, SMARTS, SMILES, InChi, etc.), as well as experience in scientific programming (e.g., Python, JAVA), data analytics (e.g., KNIME, Spotfire) and relational databases (e.g., Oracle, SQL). Additionally, applicants must be able to script work flows and implement new algorithms. Applicants also must possess strong oral and written English communication skills.

How to Apply

Please submit a cover letter describing your interest in this position, a current curriculum vitae with a complete bibliography (all in PDF format), and three letters of reference to Alexey V. Zakharov, Ph.D., at NCATSAspire-Hires@nih.gov.

The review of applications will begin immediately and will continue until the position is filled.

Stem Cell Scientist and Postdoctoral Positions, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from qualified candidates with expertise in developmental biology and human induced pluripotent stem cells (iPSCs) to fill stem cell scientist and postdoctoral positions in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the Center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as iPSCs, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems. Successful candidates will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS, external service providers and collaborators at top academic institutions.

Core Responsibilities

The selected candidates will join a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, compound management, automation engineering, bioinformatics, medicinal chemistry and various “-omics” technologies. They will work in a highly creative environment, focusing on important aspects of human pluripotency and cellular differentiation using cutting-edge technologies (e.g., single-cell analysis, deep sequencing, robotic cell culture, high-throughput electrophysiology, genome editing). They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Qualifications

Each applicant must possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Exceptional candidates with master’s degrees and strong backgrounds in stem cell biology will be considered. Candidates with experience in drug discovery, cell and tissue engineering, cell signaling, or quantitative biology are encouraged to apply. The ideal candidates should be team players with high scientific standards and have the ability to work in an interactive, fast-paced environment. They must be self-motivated to learn new technologies and be familiar with the methods and concepts of stem cell biology and regenerative medicine.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. Fellows also are able to take part in Foundation for Advanced Education in the Sciences courses at NIH.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.