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Dr. Sharon Nachman, chief of pediatric infectious diseases at Stony Brook University Hospital, is studying a leprosy drug to treat drug-resistant TB in children. Photo: Newsday / John Paraskevas

Long Island Scientists Work to Repurpose Old Medicines for New Uses

Newsday ∙ 06/18/2019 ∙ NCATS

As U.S. drug regulators were announcing approval of the first multimillion-dollar medication last month, dozens of medical scientists on Long Island and beyond were quietly working on ways of repurposing old medicines into effective new uses. Familiar medications, forgotten ones and those shelved because newer versions pushed them out of favor are poised for new roles in the treatment of an array of medical disorders, including cancer, heart conditions and infectious diseases.

June 2019

NCATS: Getting Insights Through the Risky "Middle Zone" to Drug Development
American Journal of Managed Care ∙ 06/19/2019 ∙ BrIDGs, NCATS, New Therapeutic Uses, Rare Diseases
Long Island Scientists Work to Repurpose Old Medicines for New Uses
Newsday ∙ 06/18/2019 ∙ NCATS
Scientists Recreate Blood-Brain Barrier Defect Outside the Body
HealthNewsDigest.com ∙ 06/06/2019 ∙ Tissue Chip
SpaceX Cargo Spacecraft Splashes Down in Pacific Ocean with Scientific Research
Exploring Space ∙ 06/04/2019 ∙ Tissue Chip

May 2019

Premature Death from Heart Failure Is on the Rise
Futurity ∙ 05/29/2019 ∙ CTSA Program
Will Flu’s ‘Hidden Target’ Lead to a Universal Vaccine?
Futurity ∙ 05/28/2019 ∙ CTSA Program
Agency Unveils RaDaR to Help Patient Groups Develop Rare Disease Registries
ALS News Today ∙ 05/24/2019 ∙ Rare Diseases
Shelby Announces $50 Million UAB Grant from NIH for Translational Science
Alabama Political Reporter ∙ 05/20/2019 ∙ CTSA Program
Rare Diseases Constitute a ‘Public Health Issue,’ NCATS Director Warns
Pulmonary Hypertension News ∙ 05/16/2019 ∙ Rare Diseases
Jenny Reardon Participates in Vatican Workshop on Personalized Medicine
Santa Cruz Tech Beat ∙ 05/14/2019 ∙ NCATS
In This Doctor’s Office, a Physical Exam Like No Other
The New York Times ∙ 05/08/2019 ∙ CTSA Program
You’ve Heard of ‘Organs on a Chip.’ Now ‘Tissue Chips in Space’ Test Conditions in Microgravity
STAT ∙ 05/06/2019 ∙ Tissue Chip
Tissue Chips Sent In Space To Analyze Aging-Related Conditions On Earth
Biotecnika ∙ 05/06/2019 ∙ Tissue Chip
Need to Model Aging in a Hurry? Do It in Outer Space
Awesome Investors ∙ 05/05/2019 ∙ Tissue Chip
SpaceX Launches Unpiloted Dragon Cargo Ship to Space Station
CBSNews ∙ 05/04/2019 ∙ Tissue Chip
SpaceX Will Launch Human Tissue Into Microgravity
Daily Beast ∙ 05/03/2019 ∙ Tissue Chip
SpaceX Is Launching 'Organs on a Chip' to the ISS
WIRED ∙ 05/03/2019 ∙ Tissue Chip
Woman With Rare Genetic Condition Advocates for Disabled and Shares Fitness Tips
People ∙ 05/02/2019 ∙ GARD
News Conference on the SpaceX CRS-17 Space Station Cargo Mission Pre-Launch
Fox News ∙ 05/02/2019 ∙ Tissue Chip
Living Bits of Human Organs Are Headed to the International Space Station
Inverse ∙ 05/02/2019 ∙ Tissue Chip
NASA is Sending Diseased ‘Living Human Organs’ on Micro-Chips up to the ISS to Test Sickness in Space
The Sun ∙ 05/01/2019 ∙ Tissue Chip
Q&A: Organs on a Chip Head to the International Space Station
The Scientist ∙ 05/01/2019 ∙ Tissue Chip
NIH Taps StemoniX's Organ-on-a-Chip for Opioid, Addiction Research
FierceBiotech ∙ 05/01/2019 ∙ Tissue Chip

April 2019

'Organs on Chips' Set for Launch to the International Space Station
Fox News ∙ 04/30/2019 ∙ Tissue Chip
Weird Science: Nanoparticles, Algae and Organs on Chips to Launch on SpaceX Dragon
Space.com ∙ 04/30/2019 ∙ Tissue Chip
SpaceX CRS-17 to Deliver Research Projects Impacting Life on Earth to the I.S.S.
Cheddar ∙ 04/30/2019 ∙ Tissue Chip
After Accident, SpaceX Plans to Launch to the ISS Wednesday Carrying 3,728 Pounds of Science
Orlando Sentinel ∙ 04/29/2019 ∙ Tissue Chip
Ready for Sonic Booms? NASA, SpaceX Targeting Early Morning for Falcon 9 Launch from Cape
Florida Today ∙ 04/29/2019 ∙ Tissue Chip
SpaceX Falcon 9: Why Everyone Should Wake Up to Watch This Rocket Launch
Florida Today ∙ 04/26/2019 ∙ Tissue Chip
NASA to Broadcast Next Space Station Resupply Launch, Prelaunch Activities
Mirage News ∙ 04/25/2019 ∙ Tissue Chip
Doctors Use HIV to Develop 'Cure' for Babies with 'Bubble Boy' Disease
CNN ∙ 04/18/2019 ∙ RDCRN

March 2019

Measuring Differences in Brain Chemicals in People with Mild Memory Problems
ScienceDaily ∙ 03/19/2019 ∙ CTSA Program
Artificial Intelligence Tools Could Benefit Chemists with Disabilities. So Why Aren’t They?
Chemical & Engineering News ∙ 03/18/2019 ∙ NCATS
Vaccine Candidate for HER2 Breast Cancer Shows Promise at Duke
Precision Vax LLC ∙ 03/13/2019 ∙ CTSA Program
Team Led by Rutgers Win 29 Million US Dollars NIH Grant
Health Gazette ∙ 03/13/2019 ∙ CTSA Program
With Positive Phase 2, Neurocrine Eyes Pivotal Trial for Rare Disease Drug
FierceBiotech ∙ 03/12/2019 ∙ GARD
Rutgers-Led Team Awarded $29M National Health Grant
TAPinto.net ∙ 03/12/2019 ∙ CTSA Program
Anti-Aging Mechanism May Hold Key to ‘Perfect’ Osteoporosis Treatment
Healio ∙ 03/12/2019 ∙ CTSA Program
Resuming Human Spaceflight Means Health in Space a Priority
Federal News Network ∙ 03/11/2019 ∙ NCGC
NIH Rare Disease Day Highlights Joint Networks Advancing Compelling Clinical Research
TrialSiteNews ∙ 03/08/2019 ∙ Rare Diseases
NIH Awards Virginia Health Orgs $23M for Precision Med, Pop Health Innovation
Healthcare IT News ∙ 03/06/2019 ∙ CTSA Program
Virginia Tech, UVa, Carilion and Inova Partner to Win $23 Million NIH Grant
GoDanRiver.com ∙ 03/05/2019 ∙ CTSA Program
Feverish Toddler Diagnosed with Ovarian Cancer after Doctors Tell Mom 'It's Gas'
Daily News ∙ 03/05/2019 ∙ GARD
Broken-Heart Syndrome May Stem from the Brain
Live Science ∙ 03/05/2019 ∙ GARD
NIH Hosts Rare Disease Day; Countries Around World Stage Similar Events Marking Significance of 7,000 Individually Rare Diseases That, When Taken Together, Afflict Over 400 Million People; Many Are Grievously Affected Children with Genetic Diseases
BioQuick News ∙ 03/05/2019 ∙ Rare Diseases
12 Things You Should Know about People with Rare Diseases, from Someone with Hereditary Multiple Exostoses
Odyssey ∙ 03/05/2019 ∙ GARD
A Recap of Rare Disease Week on Capitol Hill
Pain News Network ∙ 03/04/2019 ∙ Rare Diseases
Children's National Competes in STAT Madness for Second Consecutive Year
BioSpace ∙ 03/04/2019 ∙ CTSA Program
MURDOCK Study Celebrates 10th Anniversary
Independent Tribune ∙ 03/01/2019 ∙ CTSA Program
The Benefits of Sleeping in at the Weekend Don't Last, and Doing So Could Even Be Bad for Your Health
Insider ∙ 03/01/2019 ∙ CTSA Program
How Does a 2-Year-Old Get Ovarian Cancer? Doctors Explain
Health ∙ 03/01/2019 ∙ GARD

February 2019

The Children’s Inn at NIH Celebrates Rare Disease Day
MyMCMedia ∙ 02/28/2019 ∙ Rare Diseases
Vapers May Be Twice as Likely to Wheeze
Futurity ∙ 02/28/2019 ∙ CTSA Program
‘Show-Your-Rare’ on Rare Disease Day 2019
Precision Vax LLC ∙ 02/28/2019 ∙ Rare Diseases
NIH Rare Disease Day: Research Brings Hope
Clinical Leader ∙ 02/28/2019 ∙ Rare Diseases
Genetic Defect Associated with Pediatric Liver Disease Recognized
The Industry News Wire ∙ 02/28/2019 ∙ CTSA Program
Rare Diseases Aren't as Rare as They Seem
CrossTalk ∙ 02/26/2019 ∙ RDCRN
Rare Disease Day at NIH 2019
Medical Laboratory Observer ∙ 02/26/2019 ∙ Rare Diseases
Are Hip Fractures a Flag for Alzheimer’s?
Futurity ∙ 02/26/2019 ∙ CTSA Program
Higher O2 Sats with Bag-Mask Ventilation during Intubation Saves Lives
Specialty Medical Dialogues ∙ 02/20/2019 ∙ CTSA Program
CNN Chief Medical Correspondent Dr. Sanjay Gupta to Keynote 8th Annual International Space Station Research and Development Conference
SpaceRef ∙ 02/19/2019 ∙ Tissue Chip
FDA & NIH-Funded Study Finds Genetic Vulnerability to Menthol Cigarette Use
BioSpectrum ∙ 02/19/2019 ∙ CTSA Program
CRISPR/Cas9 Therapy Can Suppress Aging, Enhance Health and Extend Life Span in Mice
ScienceDaily ∙ 02/19/2019 ∙ RNAi
Laughter May Be Best Medicine -- for Brain Surgery
ScienceDaily ∙ 02/04/2019 ∙ CTSA Program
Tiny Organs in Orbit
Scientific American ∙ 02/04/2019 ∙ Tissue Chip

January 2019

FDA Revising ‘Draft Guidance’ on Developing Treatments for Rare Diseases
Hemophilia News Today ∙ 01/30/2019 ∙ RDCRN
What to Know about 'Tree Man' Syndrome
ABC News ∙ 01/28/2019 ∙ GARD
How "Bodies on a Chip" Can Transform Animal Welfare
BBC News ∙ 01/25/2019 ∙ Tissue Chip
Tackling a Common Problem for Astronauts and the Elderly: Loneliness
Politico ∙ 01/25/2019 ∙ Tissue Chip
How “Bodies on a Chip” Can Transform Animal Welfare
BBC Future ∙ 01/25/2019 ∙ CTSA Program
Lysosomal Acid Lipase Deficiency Financial Assistance Program Launched by The Assistance Fund
Associated Press ∙ 01/25/2019 ∙ GARD
Diabetic Pain Study at UAMS Enrolling Participants to Test Device
Pine Bluff Commercial ∙ 01/24/2019 ∙ CTSA Program
Low-Sugar Diet Effective in Boys with Nonalcoholic Fatty Liver Disease
ScienceBlog ∙ 01/23/2019 ∙ CTSA Program
Roy High Teen Fights an 'Invisible' Disability
Standard-Examiner ∙ 01/20/2019 ∙ GARD
Health Care: Kansas Universities Involved in Wide-Ranging Medical Research
Leavenworth Times ∙ 01/20/2019 ∙ CTSA Program
Opioids Found to Increase Risk for Community-Acquired Pneumonia, Particularly in HIV
Clinical Pain Advisor ∙ 01/18/2019 ∙ CTSA Program
A Baby Girl Who 'Never Stops Smiling' Is Living with a Rare Condition That Makes Her Skin Crack
INSIDER ∙ 01/17/2019 ∙ GARD
Gastric Bypass Surgery May Benefit Muscle Strength More than Previously Thought
ScienceDaily ∙ 01/16/2019 ∙ CTSA Program
Instagram Star Opens Up about Her Struggles with Rare Disorder where Muscle Turns to Bone
Fox News ∙ 01/13/2019 ∙ GARD
New Intestinal Microbiome Changes after Bariatric Surgery
MedicalResearch.com ∙ 01/11/2019 ∙ CTSA Program
In Small Case Series, Tocilizumab Shows Promise for New-Onset Refractory Status Epilepticus
Neurology Today ∙ 01/10/2019 ∙ GARD
Can More ‘Flags’ Help CRISPR Treat Duchenne Muscular Dystrophy?
Futurity ∙ 01/10/2019 ∙ NCATS
Opioid-related Deaths Increase Nearly 300% in Kids, Teens
Healio ∙ 01/09/2019 ∙ NCATS
PharmaBoardroom Interview with P.J. Brooks, Ph.D.
PharmaBoardroom ∙ 01/04/2019 ∙ Rare Diseases
Opioid Poisoning Killed 9,000 U.S. Kids in 20 Years
Futurity ∙ 01/02/2019 ∙ CTSA Program
To Treat Daughter’s Rare Genetic Disease, Israeli Parents Race to Invent a Cure
Times of Israel ∙ 01/02/2019 ∙ GARD
How Personalized Medicine Is Transforming Your Health Care
National Geographic ∙ 01/01/2019 ∙ Tissue Chip

December 2018

Working on a 2019 ‘To Do’ list? Here is President Trump’s 2018 ‘Done’ List
World Tribune ∙ 12/31/2018 ∙ HEAL
Seeking Better Pain Management, VT Scientists Test New Potential Drug
WVTF ∙ 12/26/2018 ∙ NCATS
Microgravity: Insight into the Ageing Process through Tissue Chips
Health Europa ∙ 12/06/2018 ∙ Tissue Chip
SNAPSHOT: New ‘Organs on a Chip’ Experiment Studies How Space Damages an Astronaut’s Body
Discover ∙ 12/06/2018 ∙ Tissue Chip
NCATS Looks to Space to Mimic Aging, Launches First Experiment
BioCentury ∙ 12/04/2018 ∙ Tissue Chip
Brilliant Science Podcast Series - Episode 5: Dr. Dan Tagle
Bioradiations ∙ 12/03/2018 ∙ Tissue Chip

November 2018

6 Hidden Dangers from Untreated Varicose Veins
KSL.com ∙ 11/29/2018 ∙ GARD
SpaceX to Carry More Than 20 New Experiments to ISS
United Press International ∙ 11/28/2018 ∙ Tissue Chip
Defense Department Funds Tech to Test Organ Tissue in lieu of Humans
PBS NewsHour ∙ 11/24/2018 ∙ Tissue Chip
Can Liver Disease Be Linked to Heart Failure? Study Highlights Liver-Heart Interaction
Medical Xpress ∙ 11/21/2018 ∙ CTSA Program
New NIH Funding Opportunities for Life Science Entrepreneurs
WRAL ∙ 11/13/2018 ∙ SBIR/STIR
NASA to Send Tissue Chips to Space to Test Human Health, Genetic Changes
NDTV ∙ 11/10/2018 ∙ Tissue Chip
NASA to Send Organs-on-Chips to Space
Times Now News ∙ 11/10/2018 ∙ Tissue Chip
Cystic Fibrosis Patients May Need Higher Doses of Antibiotics to Clear Lung Infections
MedicalResearch.com ∙ 11/08/2018 ∙ CTSA Program
Study Shows Patients with CKD and Care Providers Are at Odds over Life Goals
Healio ∙ 11/06/2018 ∙ CTSA Program
College Athlete Dies of Rare Bacterial Illness Called 'Forgotten Disease'
Life Science ∙ 11/03/2018 ∙ GARD
Kansas State University Rower Dies from Rare Bacterial Infection
FOX News Network ∙ 11/01/2018 ∙ GARD

October 2018

Fragile X Added to Newborn Screening in North Carolina Through New Study
Fragile X News Today ∙ 10/30/2018 ∙ CTSA Program
What Is VLCAD? Cheyenne’s Daughter On ‘Teen Mom OG’ Has the Serious Condition
Romper ∙ 10/29/2018 ∙ GARD
#NORDSummit – Major Issues on Table for Rare Disease Patients in US as Midterm Elections Approach
Huntington’s Disease News ∙ 10/29/2018 ∙ RDCRN
A Brutal Clock
Huffington Post ∙ 10/26/2018 ∙ Rare Diseases
Get Involved in the Rare Diseases Are Not Rare! Challenge
Patient Worthy ∙ 10/26/2018 ∙ Rare Diseases
Series of Human Physiology Projects Selected by NCATS, NIBIB for International Space Station Research
SpaceRef ∙ 10/24/2018 ∙ Tissue Chip
Two Sick Children and a $1.5 Million Bill: One Family’s Race for a Gene Therapy Cure
MIT Technology Review ∙ 10/23/2018 ∙ Rare Diseases
St. Jude Researchers Receive 'High-Risk, High-Reward' Grants
The Daily Memphian ∙ 10/16/2018 ∙ Somatic Cell Genome Editing
OSU: Big Data Helping Improve Diagnoses, Treatment
KTVZ ∙ 10/10/2018 ∙ Biomedical Data Translator
Gastric Banding as Effective as Medication in Slowing Prediabetes; Type 2 Diabetes
dLife ∙ 10/09/2018 ∙ CTSA Program
IU Researcher Receives Grant for Startup
Inside Indiana Business ∙ 10/08/2018 ∙ SBIR/STIR
Insmed Gets FDA Approval for First Mycobacterium Avium Complex (MAC) Lung Disease Therapy
Equities.com ∙ 10/04/2018 ∙ GARD
NIH Director: US Needs More Treatments for Opioid Addiction, Chronic Pain Oct
USA Today ∙ 10/03/2018 ∙ Tissue Chip

September 2018

With $7M Contract, NIH Taps Big Data Analysis Platform Palantir to Streamline Health Research
MobiHealthNews ∙ 09/24/2018 ∙ NCATS
#NORDSummit – More Than 700 Expected to Attend Oct. 15-16 Rare Disease Summit in Washington
Huntington’s Disease News ∙ 09/21/2018 ∙ NCATS
National Institutes of Health Awards Palantir with Contract to Advance Critical Health Research
OA Online ∙ 09/21/2018 ∙ NCATS
The Businessman 'Allergic' to the SUN: 30-Year-Old Battling a One-in-a-Million Condition Has Spent All His Life Avoiding Daylight
Daily Mail UK ∙ 09/21/2018 ∙ NCATS, Rare Diseases
Repurposing Existing Drugs Could Let Us Treat Intractable Illnesses
Scientific American ∙ 09/18/2018 ∙ NCATS
Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression
Psychiatry Advisor ∙ 09/18/2018 ∙ CTSA Program
Antibiotic Combos Using Four to Five Drugs Effective Against E. coli
Healio (subscription required) ∙ 09/18/2018 ∙ NCATS
Persistent Mutations in Bone Marrow Associated with Poor Myelodysplastic Syndrome Outcomes
Healio (subscription required) ∙ 09/14/2018 ∙ CTSA Program
Researchers Share Mass Screening Method against NSD2 Cancer Target
Drug Target Review ∙ 09/07/2018 ∙ NCGC
Scanning Thousands of Molecules against an Elusive Cancer Target
MD Linx ∙ 09/06/2018 ∙ NCGC
Surprising Tactic in War Vs. Antibiotic Resistance
WebMD ∙ 09/05/2018 ∙ CTSA Program
Musculoskeletal Pain Did Not Improve with Use of Mobile Health App
Healio (subscription required) ∙ 09/04/2018 ∙ CTSA Program
8,000 New Antibiotic Combinations are Surprisingly Effective
R&D Magazine ∙ 09/04/2018 ∙ NCATS
8,000 new antibiotic combinations are surprisingly effective
ScienceDaily ∙ 09/03/2018 ∙ NCATS
Low Muscle Mass in Men Associated with Poor Physical Performance, Mobility Limitations
Healio (subscription required) ∙ 09/01/2018 ∙ NCATS

August 2018

NIH Awards UNC-CH $58.1 Million to Help Move Scientific Discoveries from Labs to Practice
WRAL TechWire ∙ 08/30/2018 ∙ CTSA Program
How Effective Are Medications for Opioid Addictions after Overdoses?
Medical News Bulletin ∙ 08/28/2018 ∙ NCATS
Vascular Access and Antithrombotic Therapy in Patients with Acute Coronary Syndrome
Genetic Engineering & Biotechnology News ∙ 08/25/2018 ∙ CTSA Program
Just 21 People Are Known to Have This Rare Genetic Condition. Can You Help Us Find More?
The New York Times Magazine ∙ 08/23/2018 ∙ GARD
Baby Feces May Be Source of Beneficial Probiotics
ScienceDaily ∙ 08/23/2018 ∙ CTSA Program
Tufts Researchers Win Grant to Study Integration of Genomic Sequencing into Neonatal Care
News-Medical.Net ∙ 08/15/2018 ∙ CTSA Program