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Staff Profile: Wenwei Huang

WenWei Huang, Ph.D.
Wenwei Huang, Ph.D.

Chemistry Lead, Therapeutics for Rare and Neglected Diseases

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

E-mail Wenwei Huang

Biography

Wenwei Huang joined NIH in 2006. As a lead chemist, he has worked in various therapeutic areas, including oncology, neurological disorders, inflammation and infectious diseases. Through a collaboration with New York University, Huang developed a series of RORg inhibitors that was licensed to Orca Pharmaceuticals. Before joining NIH, Huang worked at ArQule, where his research focused on high-throughput chemistry. Huang received his Ph.D. from the University of Toronto and conducted his postdoctoral research at Emory University.

Research Topics

Huang is interested in medicinal chemistry and high-throughput chemistry. His current research focuses on developing drugs that block malaria transmission.

Selected Publications

  1. Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening.
  2. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.
  3. In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents.
  4. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.
  5. High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells.