DAta | National Center for Advancing Translational Sciences

ID	Title	Body
230	Scripps Translational Science Institute	La Jolla, California Principal InvestigatorEric J. Topol, M.D., Scripps Research Institute Website The Scripps Translational Science Institute (STSI) leads translational and clinical research for the Scripps Research Institute and Scripps Health. STSI is a collaborative investigative network that extends from the La Jolla Mesa throughout the United States. The STSI program combines one of the largest independent biomedical institutes in the world with San Diego’s dominant health care system, in partnership with the San Diego Supercomputer Center. This innovative infrastructure replaces the traditional walls separating basic scientists and clinicians, providing resources to address a full range of diseases and developing the careers of future leaders in medicine. Today’s medical practice employs mass screening and similar treatments for all patients with a particular diagnosis, despite individual differences. STSI’s areas of focus — informatics, genomics and wireless medicine — hold the keys to individualizing medicine. Major advances in genomics and wireless technologies enable the collection of bigger and more complex patient data sets. New tools such as wireless biosensors and entire genome sequencing can capture and analyze more data defining each individual patient at the biological, physiological and anatomical levels. Individualized medicine results in more effective treatments, fewer side effects, lower costs and greater precision in health care. By bringing together an innovative, multidisciplinary clinical and translational research community, STSI will help blaze the path to this new form of medicine.
229	Rockefeller University Center for Clinical and Translational Science	New York, New York Principal InvestigatorBarry Coller, M.D., The Rockefeller University Website The Rockefeller University Hospital, originally a General Clinical Research Center awardee since 1963, has been the continuous home for clinical and translational science at Rockefeller since 1910. It has been the site of numerous landmark scientific and clinical contributions, and many of its trainees have gone on to become academic leaders. With the new resources available under a Clinical and Translational Science Award (CTSA), a core faculty of distinguished investigators, whose research spans the basic-translational spectrum and encompasses a broad range of scientific and medical disciplines, integrates and expands Rockefeller University's scientific and educational programs in the Rockefeller University Center for Clinical and Translational Science. The new center transforms clinical and translational research by encouraging new studies, enhancing and centralizing the support structures required to conduct studies with scientific rigor, and ensuring an absolute commitment to the protection of human subjects and participant safety. The key elements in the transformation are: A new governance structure reflecting the NIH cooperative agreement (U54) assistance mechanism; Creation of a new K12 Clinical Research Scholars Program offering master's and Ph.D.-level degrees to complement the current Clinical Scholars Program; Infrastructure enhancements to facilitate the development and conduct of clinical protocols under the principle of good clinical practice, including biomedical informatics, biostatistics, bionutrition, research nursing, research pharmacy, participant recruitment and community engagement, and regulatory support and oversight from the clinical research (research subject advocate) support office; and Development of innovative and novel core methodologies related to dendritic cell therapy; vaccine development for HIV, hepatitis C and malignancies; genetics/genomics; assessing the immune response; and metabolic phenotyping. The center continues Rockefeller's tradition of focusing on the interface between scientific discovery; human pathophysiology; and novel diagnostic, preventive and therapeutic strategies. It partners with industry, when mutually beneficial, to achieve these goals. The center is an active member of the national CTSA consortium, offering the consortium novel ideas and tools for conducting and evaluating clinical and translational research. It eagerly adopts the best practices identified by the consortium and adheres to the standards set by the consortium.
228	Penn State Clinical and Translational Science Institute	Hershey, Pennsylvania Principal InvestigatorLawrence I. Sinoway, M.D., Penn State Milton S. Hershey Medical Center Website The overarching goal of the Penn State Clinical and Translational Science Institute (CTSI) is to revitalize the health science research and education enterprise at Penn State to better enable it to deliver on the promise of improved health. Throughout the university, CTSI has broad support across colleges, campuses and partner organizations. With strengths in relevant biological, social and physical sciences and an organizational structure that encourages collaboration across units, CTSI plans to: Bolster community alliances to strengthen trust, enhance awareness of disparities and ascertain needs; Cultivate new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry; Share resources and promote their most proficient use; Capitalize on novel tools in information technology to collect, share and mine data, and disseminate new knowledge; and Educate a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Some of the key features of the Penn State CTSI are to expand biomedical informatics and develop new software solutions to study genetics, epigenetics and systems biology. Jointly with its community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, prevent and treat disease in the people it serves.
227	Oregon Clinical and Translational Research Institute	Portland, Oregon Principal Investigator David Ellison, M.D., Oregon Health & Science University Website The Oregon Clinical and Translational Research Institute (OCTRI) aims to fundamentally change biomedical research in Oregon and beyond by creating a vibrant academic home for clinical and translational investigation while leveraging existing strengths and removing barriers to the pace and growth of research. OCTRI has identified strategic aims for facilitating and supporting clinical and translational research and has proposed far-reaching, explicit and feasible approaches to achieve them. OCTRI strives to: Catalyze translational research. Develop the translational workforce. Cultivate innovation in research. Foster and support scientific collaboration. Enhance partnerships with community. Through strategic pilot project funding, research services, collaboration and education, OCTRI is working to make a significant difference in the lives and work of researches, educators, students, industry and the human population.
226	The Ohio State University Center for Clinical and Translational Science	Columbus, Ohio Principal InvestigatorRebecca D. Jackson, M.D., The Ohio State University Website The Ohio State University's Center for Clinical and Translational Science (OSU CCTS) brings together research teams and fosters innovation to translate science more quickly into patient care. In partnership with the Nationwide Children’s Hospital, the Center aims to: Draw on the University’s diverse strengths to create an academic home for innovative, team-oriented clinical and translational science. Nurture the career development of highly trained investigators, with an emphasis on innovation and science across disciplines. Build an administrative infrastructure to conduct high-quality clinical and translational science applicable and relevant to communities. Develop a portfolio of outstanding shared resources in support of transformative clinical and translational research. The Center will continue to blend the traditional biomedical research process — basic scientific discovery, translated to the bedside, then disseminated into the community — with a public health approach (i.e., surveillance to prevention to response). Using this hybrid model, the Center will stimulate basic discovery and clinical research analysis, ultimately creating a robust translational science infrastructure. CCTS will conduct focused initiatives to develop new teams within an innovation ecosystem. Investigators will develop core competencies in research methodology; interpretation of results; implementation of findings; design thinking; and discipline-specific bench, clinical and community laboratory procedures. Investigators also will cultivate team leadership and business skills. The Center will build a clinical and translational science infrastructure to provide a range of scientific resources needed to conduct all forms of translational research.
225	Northwestern University Clinical and Translational Sciences Institute	Evanston and Chicago, Illinois Principal InvestigatorDonald M. Lloyd-Jones, M.D., Sc.M., Northwestern University Website The Northwestern University Clinical and Translational Sciences Institute (NUCATS) is dedicated to facilitating, supporting and promoting research that results in better medical treatments and improved health care. NUCATS is the physical home and central hub for translational research across the Northwestern University enterprise. The institute is composed of five centers, and participation spans several geographic locations, including the involvement of all four NU-affiliated hospitals and six NU schools located on two campuses: the Feinberg School of Medicine, the Kellogg School of Management, the McCormick School of Engineering and Applied Science, the School of Communication, the School of Education and Social Policy, and the Weinberg College of Arts and Sciences. Basic scientists, medical practitioners, community-based medical practitioners and community-based organizations are working together with leaders in the fields of communications, education, business and public health to eliminate barriers to innovation.
224	North Carolina Translational and Clinical Sciences Institute	Chapel Hill, North Carolina Principal Investigator John B. Buse, M.D., Ph.D., University of North Carolina at Chapel Hill Timothy S. Carey, M.D., M.P.H., University of North Carolina at Chapel Hill Website The integrated hub of the Clinical and Translational Science Awards (CTSA) Program at the University of North Carolina (UNC) combines the research strengths, resources and opportunities of the UNC Chapel Hill campus, partner institutions RTI International in the Research Triangle Park and North Carolina Agricultural and Technical State University in Greensboro. This collaboration is strategically designed to overcome barriers that historically have been responsible for fragmenting and delaying research efforts. Faculty and staff experts across North Carolina Translational and Clinical Sciences (NC TraCS) Institute offer targeted, comprehensive and interdisciplinary solutions to investigators in the area of clinical and translational science, serving as the sole, centralized portal through which researchers may gain access to the resources and services. The NC TraCS Institute capitalizes on the accessibility of all of this knowledge and experience by coordinating expertise in research resources and services, to the benefit of the research community at large.
223	New York University Clinical and Translational Science Institute	New York, New York Principal InvestigatorsBruce Neil Cronstein, M.D., New York University Langone Medical CenterJudith S. Hochman, M.D., New York University Langone Medical Center Website To transform the way research is carried out at New York University (NYU) and enhance the quality and productivity of the research effort, NYU and the New York City Health and Hospitals Corporation (HHC) has established a Clinical and Translational Science Institute (CTSI). CTSI aims to increase collaboration among clinical, translational and basic scientists across NYU to better determine the relevance and applicability of scientific advances to clinical problems. It also strives to provide leadership, infrastructure and resources to support novel science and the rapid, efficient and safe application of scientific discoveries to the community. A third aim is to support education, training and development of researchers who can conduct the investigations necessary to bring scientific advances to the public. Finally, CTSI works to enhance the ties between NYU researchers and the community in order to more rapidly identify health problems, investigate their scientific basis, apply the knowledge gained, promote use of new developments and evidence-based medicine by the community, and reduce health care disparities. CTSI links NYU and the HHC in a new venture designed to bring their resources to bear on the health problems facing New York and the nation in the 21st century. Combining strengths and synergies in research, patient care and community outreach, it provides a new and innovative engine for translation of medical advances from the laboratory to the patient and from the patient to the community.
222	Michigan Institute for Clinical and Health Research	Ann Arbor, Michigan Principal Investigator George A. Mashour, M.D., University of Michigan Website The Michigan Institute for Clinical and Health Research creates partnerships among the relevant units of the university, NIH, external industry partners and the community. The overwhelming majority of University of Michigan (UM) schools, colleges and institutes are participating, including: the top-ranked Schools of Business, Dentistry, Medicine, Nursing, Social Work and Public Health; the Colleges of Engineering, Pharmacy, Literature, and Science and Arts; the Division of Kinesiology; the Institute of Social Research; and the Life Sciences Institute. The university-owned Health System, which includes integrated outpatient and inpatient facilities, is contributing significantly to a strong partnership with the UM CTSA Program hub. In addition to the grant resources, the institution is contributing substantial in-kind support, cost-sharing, support of pilot and recruitment programs, and renovation costs, a more than 1:1 match of NIH dollars. The UM CTSA Program hub includes an Education Program that reaches a wide spectrum of audiences, from undergraduates to mid-career faculty, from basic scientists to population researchers, and from staff to community members.
221	Miami Clinical and Translational Science Institute	Miami, Florida Principal Investigator Ralph L. Sacco, M.D., University of Miami Website In a region that is more than 88 percent racial/ethnic minorities, members of the Miami Clinical and Translational Science Institute (CTSI) work together to drive scientific discovery and its translation into evidence-based practices that improve the health of South Floridians. The mission of the Miami CTSI is to improve the quality and efficacy of clinical and translational research, advance team science, and integrate culture with health science. Unique among CTSA Program hubs, the Miami CTSI is co-funded by NIH’s National Institute on Minority Health and Health Disparities. Involving the larger Miami community in a transformational process, the Miami CTSI has a far-reaching research enterprise that encompasses internationally renowned clinical services; world-class research in areas of highly visible public concern, such as child health, obesity, diabetes, drug abuse, HIV, spinal cord injury, cancer and eye disease; pioneering medical training initiatives throughout the hemisphere; and a nationally recognized 40-year record of exemplary community engagement and research. Fundamental to accomplishing Miami CTSI’s mission is the orchestration of research programs, services, resources and training in novel ways that foster excellence in discovery, innovation and translation; elevate research ethics; promote collaboration among diverse disciplines; and build full research partnerships with diverse communities.

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